ECSP18073245A - Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue - Google Patents
Derivados de indol sustituidos como inhibidores de la replicación vírica del dengueInfo
- Publication number
- ECSP18073245A ECSP18073245A ECSENADI201873245A ECDI201873245A ECSP18073245A EC SP18073245 A ECSP18073245 A EC SP18073245A EC SENADI201873245 A ECSENADI201873245 A EC SENADI201873245A EC DI201873245 A ECDI201873245 A EC DI201873245A EC SP18073245 A ECSP18073245 A EC SP18073245A
- Authority
- EC
- Ecuador
- Prior art keywords
- inhibitors
- compounds
- dengue
- relates
- viral replication
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a derivados de indol sustituidos, a métodos para prevenir o tratar infecciones víricas por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferiblemente, para su uso como medicamento para tratar o prevenir infecciones víricas por dengue. La presente invención se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como un medicamento, más preferiblemente para la prevención o el tratamiento de infecciones víricas por dengue. La invención también se refiere a procesos para la preparación de los compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163312 | 2016-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18073245A true ECSP18073245A (es) | 2018-10-31 |
Family
ID=55650292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201873245A ECSP18073245A (es) | 2016-03-31 | 2018-09-28 | Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US10646469B2 (es) |
| EP (1) | EP3436435B1 (es) |
| JP (1) | JP6888021B2 (es) |
| KR (1) | KR102359743B1 (es) |
| CN (1) | CN108884033B (es) |
| AU (1) | AU2017242893A1 (es) |
| BR (1) | BR112018068676A2 (es) |
| CA (1) | CA3013405A1 (es) |
| CL (1) | CL2018002729A1 (es) |
| CO (1) | CO2018009559A2 (es) |
| CR (1) | CR20180495A (es) |
| DK (1) | DK3436435T3 (es) |
| EA (1) | EA201892214A1 (es) |
| EC (1) | ECSP18073245A (es) |
| ES (1) | ES2882488T3 (es) |
| HK (1) | HK1258142A1 (es) |
| HR (1) | HRP20210847T1 (es) |
| HU (1) | HUE054936T2 (es) |
| IL (1) | IL261944A (es) |
| LT (1) | LT3436435T (es) |
| MX (1) | MX2018011784A (es) |
| PE (1) | PE20181772A1 (es) |
| PH (1) | PH12018502015A1 (es) |
| SG (1) | SG11201808138YA (es) |
| SI (1) | SI3436435T1 (es) |
| WO (1) | WO2017167950A1 (es) |
| ZA (1) | ZA201806473B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CR20190531A (es) | 2017-05-22 | 2020-03-05 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| PH12022551160A1 (en) | 2019-11-15 | 2023-09-25 | Janssen Pharmaceuticals Inc | Treatment and prevention of dengue disease |
| WO2024178504A1 (en) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Tri-halo-alkoxy-substituted tryptamine derivatives and methods of using |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| EP1519735A4 (en) | 2001-12-12 | 2006-01-11 | Conforma Therapeutic Corp | ASSAYS AND DEVICES FOR DETERMINING AND MODULATING HSP90 BINDING ACTIVITY |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| CN101103026A (zh) | 2005-01-14 | 2008-01-09 | 健亚生物科技公司 | 用于治疗病毒感染的吲哚衍生物 |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| EP2331499B1 (en) * | 2008-08-19 | 2016-09-21 | Janssen Pharmaceutica NV | Cold menthol receptor antagonists |
| WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| EA201290575A1 (ru) | 2010-01-15 | 2013-01-30 | Джилид Сайэнс, Инк. | Ингибиторы вирусов flaviviridae |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| JP6505727B2 (ja) | 2014-01-31 | 2019-04-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロ環式ｐ２’基を有する第ｘｉａ因子阻害剤としてのマクロ環 |
| NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
| US9944598B2 (en) | 2014-10-01 | 2018-04-17 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| BR112017006708A2 (pt) | 2014-10-01 | 2017-12-26 | Janssen Pharmaceuticals Inc | indóis mono- ou dissubstituídos como inibidores da replicação viral de dengue |
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CA3002214C (en) | 2015-11-03 | 2022-01-04 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
| UY37174A (es) | 2016-03-31 | 2017-10-31 | Takeda Pharmaceuticals Co | Un compuesto heterocíclico que tiene una acción inhibidora de monoacilglicerol lipasa |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| HRP20210847T1 (hr) | 2016-03-31 | 2021-07-23 | Janssen Pharmaceuticals, Inc. | Supstituirani derivati indola kao inhibitori replikacije denga virusa |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| US10576085B2 (en) | 2016-04-01 | 2020-03-03 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| KR102427334B1 (ko) | 2016-04-01 | 2022-08-03 | 카이트 파마 인코포레이티드 | 키메라 항원 및 t 세포 수용체 및 사용 방법 |
| SG10201912519VA (en) | 2016-04-01 | 2020-02-27 | Kite Pharma Inc | Chimeric receptors and methods of use thereof |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2017240801A1 (en) | 2016-04-01 | 2018-10-25 | Amgen Inc. | Chimeric receptors to FLT3 and methods of use thereof |
| MX2018012016A (es) | 2016-04-01 | 2019-01-24 | Basf Se | Compuestos biciclicos. |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CR20190531A (es) | 2017-05-22 | 2020-03-05 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| CA3060583C (en) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
-
2017
- 2017-03-31 HR HRP20210847TT patent/HRP20210847T1/hr unknown
- 2017-03-31 EA EA201892214A patent/EA201892214A1/ru unknown
- 2017-03-31 CR CR20180495A patent/CR20180495A/es unknown
- 2017-03-31 JP JP2018549441A patent/JP6888021B2/ja active Active
- 2017-03-31 AU AU2017242893A patent/AU2017242893A1/en not_active Abandoned
- 2017-03-31 HU HUE17714750A patent/HUE054936T2/hu unknown
- 2017-03-31 MX MX2018011784A patent/MX2018011784A/es unknown
- 2017-03-31 HK HK19100496.8A patent/HK1258142A1/zh unknown
- 2017-03-31 LT LTEP17714750.1T patent/LT3436435T/lt unknown
- 2017-03-31 SG SG11201808138YA patent/SG11201808138YA/en unknown
- 2017-03-31 WO PCT/EP2017/057660 patent/WO2017167950A1/en not_active Ceased
- 2017-03-31 DK DK17714750.1T patent/DK3436435T3/da active
- 2017-03-31 ES ES17714750T patent/ES2882488T3/es active Active
- 2017-03-31 CA CA3013405A patent/CA3013405A1/en not_active Abandoned
- 2017-03-31 KR KR1020187027072A patent/KR102359743B1/ko active Active
- 2017-03-31 SI SI201730800T patent/SI3436435T1/sl unknown
- 2017-03-31 BR BR112018068676-0A patent/BR112018068676A2/pt not_active Application Discontinuation
- 2017-03-31 PE PE2018001878A patent/PE20181772A1/es unknown
- 2017-03-31 CO CONC2018/0009559A patent/CO2018009559A2/es unknown
- 2017-03-31 EP EP17714750.1A patent/EP3436435B1/en active Active
- 2017-03-31 CN CN201780021395.5A patent/CN108884033B/zh active Active
- 2017-03-31 US US16/087,800 patent/US10646469B2/en active Active
-
2018
- 2018-09-20 PH PH12018502015A patent/PH12018502015A1/en unknown
- 2018-09-26 CL CL2018002729A patent/CL2018002729A1/es unknown
- 2018-09-26 IL IL261944A patent/IL261944A/en unknown
- 2018-09-28 ZA ZA2018/06473A patent/ZA201806473B/en unknown
- 2018-09-28 EC ECSENADI201873245A patent/ECSP18073245A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019510024A (ja) | 2019-04-11 |
| HUE054936T2 (hu) | 2021-10-28 |
| KR20180130498A (ko) | 2018-12-07 |
| BR112018068676A2 (pt) | 2019-01-15 |
| SI3436435T1 (sl) | 2021-08-31 |
| MX2018011784A (es) | 2019-02-13 |
| JP6888021B2 (ja) | 2021-06-16 |
| HK1258142A1 (zh) | 2019-11-08 |
| LT3436435T (lt) | 2021-08-25 |
| KR102359743B1 (ko) | 2022-02-07 |
| WO2017167950A1 (en) | 2017-10-05 |
| ZA201806473B (en) | 2020-05-27 |
| EP3436435B1 (en) | 2021-05-12 |
| HRP20210847T1 (hr) | 2021-07-23 |
| PE20181772A1 (es) | 2018-10-31 |
| AU2017242893A1 (en) | 2018-08-09 |
| CO2018009559A2 (es) | 2018-09-20 |
| US20190274999A1 (en) | 2019-09-12 |
| US10646469B2 (en) | 2020-05-12 |
| CA3013405A1 (en) | 2017-10-05 |
| EP3436435A1 (en) | 2019-02-06 |
| ES2882488T3 (es) | 2021-12-02 |
| CN108884033B (zh) | 2021-03-09 |
| SG11201808138YA (en) | 2018-10-30 |
| EA201892214A1 (ru) | 2019-03-29 |
| PH12018502015A1 (en) | 2019-07-15 |
| CR20180495A (es) | 2018-12-06 |
| CN108884033A (zh) | 2018-11-23 |
| IL261944A (en) | 2018-10-31 |
| CL2018002729A1 (es) | 2018-11-23 |
| DK3436435T3 (da) | 2021-08-09 |
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