ECSP18073245A - Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue - Google Patents
Derivados de indol sustituidos como inhibidores de la replicación vírica del dengueInfo
- Publication number
- ECSP18073245A ECSP18073245A ECSENADI201873245A ECDI201873245A ECSP18073245A EC SP18073245 A ECSP18073245 A EC SP18073245A EC SENADI201873245 A ECSENADI201873245 A EC SENADI201873245A EC DI201873245 A ECDI201873245 A EC DI201873245A EC SP18073245 A ECSP18073245 A EC SP18073245A
- Authority
- EC
- Ecuador
- Prior art keywords
- inhibitors
- compounds
- dengue
- relates
- viral replication
- Prior art date
Links
- 206010012310 Dengue fever Diseases 0.000 title abstract 4
- 208000025729 dengue disease Diseases 0.000 title abstract 4
- 208000001490 Dengue Diseases 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 3
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a derivados de indol sustituidos, a métodos para prevenir o tratar infecciones víricas por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferiblemente, para su uso como medicamento para tratar o prevenir infecciones víricas por dengue. La presente invención se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como un medicamento, más preferiblemente para la prevención o el tratamiento de infecciones víricas por dengue. La invención también se refiere a procesos para la preparación de los compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163312 | 2016-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18073245A true ECSP18073245A (es) | 2018-10-31 |
Family
ID=55650292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201873245A ECSP18073245A (es) | 2016-03-31 | 2018-09-28 | Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10646469B2 (es) |
| EP (1) | EP3436435B1 (es) |
| JP (1) | JP6888021B2 (es) |
| KR (1) | KR102359743B1 (es) |
| CN (1) | CN108884033B (es) |
| AU (1) | AU2017242893A1 (es) |
| BR (1) | BR112018068676A2 (es) |
| CA (1) | CA3013405A1 (es) |
| CL (1) | CL2018002729A1 (es) |
| CO (1) | CO2018009559A2 (es) |
| CR (1) | CR20180495A (es) |
| DK (1) | DK3436435T3 (es) |
| EA (1) | EA201892214A1 (es) |
| EC (1) | ECSP18073245A (es) |
| ES (1) | ES2882488T3 (es) |
| HK (1) | HK1258142A1 (es) |
| HR (1) | HRP20210847T1 (es) |
| HU (1) | HUE054936T2 (es) |
| IL (1) | IL261944A (es) |
| LT (1) | LT3436435T (es) |
| MX (1) | MX2018011784A (es) |
| PH (1) | PH12018502015A1 (es) |
| SG (1) | SG11201808138YA (es) |
| SI (1) | SI3436435T1 (es) |
| WO (1) | WO2017167950A1 (es) |
| ZA (1) | ZA201806473B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN109195949B (zh) * | 2016-03-31 | 2021-09-17 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| EA201892214A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индола в качестве ингибиторов репликации вирусов денге |
| ES3010298T3 (en) * | 2016-04-01 | 2025-04-02 | Janssen Pharmaceuticals Inc | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CR20190530A (es) | 2017-05-22 | 2020-01-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación viral de dengue |
| EP3630724B1 (en) | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| WO2024178504A1 (en) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Tri-halo-alkoxy-substituted tryptamine derivatives and methods of using |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| US20050074457A1 (en) | 2001-12-12 | 2005-04-07 | Adeela Kamal | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US20060211698A1 (en) | 2005-01-14 | 2006-09-21 | Genelabs, Inc. | Bicyclic heteroaryl derivatives for treating viruses |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| AU2009256390A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| ES2612731T3 (es) * | 2008-08-19 | 2017-05-18 | Janssen Pharmaceutica Nv | Antagonistas de receptores al frío de mentol |
| WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| CA2785563C (en) | 2010-01-15 | 2019-05-14 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| PE20210470A1 (es) | 2014-01-31 | 2021-03-08 | Bristol Myers Squibb Co | Macrociclos con grupos p2' heterociclicos como inhibidores del factor xia |
| US9944598B2 (en) | 2014-10-01 | 2018-04-17 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors |
| NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
| AU2015326920A1 (en) | 2014-10-01 | 2017-03-02 | Janssen Pharmaceuticals, Inc. | Mono- or di-substituted indoles as dengue viral replication inhibitors |
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| RU2761212C2 (ru) | 2015-11-03 | 2021-12-06 | Зоэтис Сервисиз Ллс | Полимерные композиты, полученные по способу золь-гель, и их применение |
| US10323026B2 (en) | 2016-03-31 | 2019-06-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EA201892214A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индола в качестве ингибиторов репликации вирусов денге |
| CN109195949B (zh) | 2016-03-31 | 2021-09-17 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| ES3010298T3 (en) | 2016-04-01 | 2025-04-02 | Janssen Pharmaceuticals Inc | Substituted indole compound derivatives as dengue viral replication inhibitors |
| SI3436030T1 (sl) | 2016-04-01 | 2023-01-31 | Kite Pharma, Inc. | Himerni receptorji in načini njihove uporabe |
| UA128326C2 (uk) | 2016-04-01 | 2024-06-12 | Амджен Інк. | Химерний рецептор до flt3 та спосіб його застосування |
| TWI691596B (zh) | 2016-04-01 | 2020-04-21 | 美商凱特製藥公司 | 嵌合抗原和ｔ細胞受體及使用方法 |
| EA039392B1 (ru) | 2016-04-01 | 2022-01-21 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способ лечения рака с применением замещенного аминопуринового соединения |
| US11570992B2 (en) | 2016-04-01 | 2023-02-07 | Basf Se | Bicyclic compounds |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3630724B1 (en) | 2017-05-22 | 2021-04-28 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| CR20190530A (es) | 2017-05-22 | 2020-01-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación viral de dengue |
-
2017
- 2017-03-31 EA EA201892214A patent/EA201892214A1/ru unknown
- 2017-03-31 JP JP2018549441A patent/JP6888021B2/ja active Active
- 2017-03-31 HR HRP20210847TT patent/HRP20210847T1/hr unknown
- 2017-03-31 HK HK19100496.8A patent/HK1258142A1/zh unknown
- 2017-03-31 SI SI201730800T patent/SI3436435T1/sl unknown
- 2017-03-31 SG SG11201808138YA patent/SG11201808138YA/en unknown
- 2017-03-31 ES ES17714750T patent/ES2882488T3/es active Active
- 2017-03-31 US US16/087,800 patent/US10646469B2/en active Active
- 2017-03-31 AU AU2017242893A patent/AU2017242893A1/en not_active Abandoned
- 2017-03-31 CN CN201780021395.5A patent/CN108884033B/zh active Active
- 2017-03-31 CA CA3013405A patent/CA3013405A1/en not_active Abandoned
- 2017-03-31 CR CR20180495A patent/CR20180495A/es unknown
- 2017-03-31 KR KR1020187027072A patent/KR102359743B1/ko active Active
- 2017-03-31 WO PCT/EP2017/057660 patent/WO2017167950A1/en not_active Ceased
- 2017-03-31 DK DK17714750.1T patent/DK3436435T3/da active
- 2017-03-31 CO CONC2018/0009559A patent/CO2018009559A2/es unknown
- 2017-03-31 LT LTEP17714750.1T patent/LT3436435T/lt unknown
- 2017-03-31 MX MX2018011784A patent/MX2018011784A/es unknown
- 2017-03-31 EP EP17714750.1A patent/EP3436435B1/en active Active
- 2017-03-31 BR BR112018068676A patent/BR112018068676A2/pt not_active Application Discontinuation
- 2017-03-31 HU HUE17714750A patent/HUE054936T2/hu unknown
-
2018
- 2018-09-20 PH PH12018502015A patent/PH12018502015A1/en unknown
- 2018-09-26 CL CL2018002729A patent/CL2018002729A1/es unknown
- 2018-09-26 IL IL261944A patent/IL261944A/en unknown
- 2018-09-28 EC ECSENADI201873245A patent/ECSP18073245A/es unknown
- 2018-09-28 ZA ZA2018/06473A patent/ZA201806473B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL261944A (en) | 2018-10-31 |
| CN108884033B (zh) | 2021-03-09 |
| HRP20210847T1 (hr) | 2021-07-23 |
| ZA201806473B (en) | 2020-05-27 |
| HUE054936T2 (hu) | 2021-10-28 |
| WO2017167950A1 (en) | 2017-10-05 |
| ES2882488T3 (es) | 2021-12-02 |
| JP2019510024A (ja) | 2019-04-11 |
| AU2017242893A1 (en) | 2018-08-09 |
| SG11201808138YA (en) | 2018-10-30 |
| BR112018068676A2 (pt) | 2019-01-15 |
| HK1258142A1 (zh) | 2019-11-08 |
| MX2018011784A (es) | 2019-02-13 |
| JP6888021B2 (ja) | 2021-06-16 |
| US10646469B2 (en) | 2020-05-12 |
| LT3436435T (lt) | 2021-08-25 |
| EP3436435A1 (en) | 2019-02-06 |
| PH12018502015A1 (en) | 2019-07-15 |
| CO2018009559A2 (es) | 2018-09-20 |
| US20190274999A1 (en) | 2019-09-12 |
| DK3436435T3 (da) | 2021-08-09 |
| EP3436435B1 (en) | 2021-05-12 |
| KR102359743B1 (ko) | 2022-02-07 |
| SI3436435T1 (sl) | 2021-08-31 |
| CN108884033A (zh) | 2018-11-23 |
| CA3013405A1 (en) | 2017-10-05 |
| KR20180130498A (ko) | 2018-12-07 |
| EA201892214A1 (ru) | 2019-03-29 |
| CR20180495A (es) | 2018-12-06 |
| CL2018002729A1 (es) | 2018-11-23 |
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