ECSP18077068A - Composiciones y métodos para aumentar la ingesta de hierro en un mamífero - Google Patents

Composiciones y métodos para aumentar la ingesta de hierro en un mamífero

Info

Publication number
ECSP18077068A
ECSP18077068A ECSENADI201877068A ECDI201877068A ECSP18077068A EC SP18077068 A ECSP18077068 A EC SP18077068A EC SENADI201877068 A ECSENADI201877068 A EC SENADI201877068A EC DI201877068 A ECDI201877068 A EC DI201877068A EC SP18077068 A ECSP18077068 A EC SP18077068A
Authority
EC
Ecuador
Prior art keywords
iron
compositions
mammal
methods
individual
Prior art date
Application number
ECSENADI201877068A
Other languages
English (en)
Inventor
Pat Ledwidge
John Gilmer
Pat O´Flynn
Radics Gabor
Michael Whelehan
Jun Wang
Original Assignee
Solvotrin Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvotrin Therapeutics Ltd filed Critical Solvotrin Therapeutics Ltd
Publication of ECSP18077068A publication Critical patent/ECSP18077068A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Se ha preparado composiciones que contienen hierro, amortiguador y proteína desnaturalizada capaces de elevar el hierro sérico en un individuo. Por ejemplo, se ha preparado microperlas con contenido de hierro mediante el secado por atomización, contenidas en una matriz proteica y de hierro no fijado en una composición amortiguada que ofrece un efecto de protección gástrica, que conserva el hierro en forma de Fe 2+ con mayor disponibilidad y que mejora la biodisponibilidad de hierro en los seres humanos en relación con los vehículos conocidos previamente para proporcionar hierro a un individuo.
ECSENADI201877068A 2016-03-15 2018-10-12 Composiciones y métodos para aumentar la ingesta de hierro en un mamífero ECSP18077068A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16160539 2016-03-15

Publications (1)

Publication Number Publication Date
ECSP18077068A true ECSP18077068A (es) 2018-12-31

Family

ID=55640537

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201877068A ECSP18077068A (es) 2016-03-15 2018-10-12 Composiciones y métodos para aumentar la ingesta de hierro en un mamífero

Country Status (32)

Country Link
US (1) US11224615B2 (es)
EP (1) EP3429560B1 (es)
JP (1) JP7193145B2 (es)
KR (1) KR102403292B1 (es)
CN (1) CN109069430B (es)
AU (1) AU2017232266B2 (es)
BR (1) BR112018068571A2 (es)
CA (1) CA3017556C (es)
CL (1) CL2018002632A1 (es)
CO (1) CO2018010940A2 (es)
CR (1) CR20180488A (es)
CU (1) CU20180108A7 (es)
EA (1) EA201892065A1 (es)
EC (1) ECSP18077068A (es)
ES (1) ES3008084T3 (es)
GE (2) GEP20227445B (es)
HR (1) HRP20250187T1 (es)
HU (1) HUE070063T2 (es)
IL (1) IL261735B (es)
MA (1) MA43703A (es)
MX (1) MX2018011227A (es)
MY (1) MY196575A (es)
NI (1) NI201800089A (es)
NZ (1) NZ747227A (es)
PE (1) PE20181955A1 (es)
PH (1) PH12018501994A1 (es)
PL (1) PL3429560T3 (es)
SA (1) SA518400019B1 (es)
SG (1) SG11201807985XA (es)
UA (1) UA125211C2 (es)
WO (1) WO2017158030A1 (es)
ZA (1) ZA201806814B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114027507B (zh) * 2021-11-18 2023-02-28 中国农业大学 一种口服凝胶铁补充剂及其制备方法
WO2024145451A2 (en) * 2022-12-29 2024-07-04 Memorial Sloan-Kettering Cancer Center Methods for restoring regenerative potential of aged lung alveoli and aged adult stem cell compartments

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US505986A (en) 1893-10-03 Pio marfori
US4167564A (en) * 1974-09-23 1979-09-11 Albion Laboratories, Inc. Biological assimilation of metals
US4067994A (en) 1976-03-26 1978-01-10 Zinpro Corporation Iron methionine complex salts
US4216144A (en) 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
IT1150213B (it) 1982-03-02 1986-12-10 Italfarmaco Spa Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche
IT1186787B (it) 1985-11-06 1987-12-16 Mediolanum Farmaceutici Srl Ferro-derivati della globina e dell'acetilglobina dotati di elevata biodisponibilita',processo di preparazione e composizioni farmaceutiche
US5418010A (en) 1990-10-05 1995-05-23 Griffith Laboratories Worldwide, Inc. Microencapsulation process
JP3404294B2 (ja) * 1998-08-11 2003-05-06 雪印乳業株式会社 鉄−ホエー蛋白質加水分解物複合体
US6521247B1 (en) 1999-08-13 2003-02-18 Warner Chilcott Laboratories Ireland Limited Dual iron containing nutritional supplement
JP4744448B2 (ja) * 2003-10-30 2011-08-10 アルラ・フーズ・エイ・エム・ビィ・エイ 低脂肪スプレッド製造において有用な安定剤
CN1557481A (zh) * 2004-02-04 2004-12-29 高春平 防治缺铁性贫血的天然营养剂
US20060134227A1 (en) * 2004-12-22 2006-06-22 Bortz Jonathan D Compositions including iron
US7585527B2 (en) * 2005-09-19 2009-09-08 Bala Venkataraman Composition and method for treating iron deficiency anemia
KR20090045945A (ko) * 2006-08-25 2009-05-08 베링거 인겔하임 인터내셔날 게엠베하 제어 방출 시스템 및 이의 제조방법
CN101143011B (zh) 2007-10-09 2011-06-22 浙江大学 提高食物中铁素生物有效性的方法
US20090124572A1 (en) 2007-11-09 2009-05-14 Deanna Jean Nelson Iron-containing nutritional supplement
CN101928742B (zh) 2009-06-23 2013-02-27 光明乳业股份有限公司 一种具有抗氧化性活性的乳清蛋白活性肽及其制备方法
WO2012097155A1 (en) 2011-01-14 2012-07-19 Chiasma Inc. Improved pharmaceutical compositions for delivery of ferric iron compounds, and methods of use thereof
ES2559455T3 (es) 2011-07-15 2016-02-12 Nestec S.A. Encapsulado de calidad alimentaria y su procedimiento de fabricación
AU2012311964B2 (en) * 2011-09-22 2016-09-22 Amip Buffered upper GI absorption promoter
WO2014148886A1 (en) * 2013-03-22 2014-09-25 N.V. Nutricia Fermented nutrition high in lactose with increased iron bioavailability
GB201416293D0 (en) * 2014-09-15 2014-10-29 Solvotrin Therapeutics Ltd Methods and preparations
EP2995205A1 (en) 2014-09-15 2016-03-16 Anabio Technologies Limited Compositions and methods for the maintenance of adequate iron intake in a mammal

Also Published As

Publication number Publication date
JP7193145B2 (ja) 2022-12-20
US11224615B2 (en) 2022-01-18
PE20181955A1 (es) 2018-12-17
NZ747227A (en) 2022-11-25
NI201800089A (es) 2019-05-16
JP2019511572A (ja) 2019-04-25
ZA201806814B (en) 2021-03-31
CO2018010940A2 (es) 2018-11-22
AU2017232266A1 (en) 2018-11-08
IL261735A (en) 2018-10-31
CA3017556A1 (en) 2017-09-21
BR112018068571A2 (pt) 2019-04-16
SG11201807985XA (en) 2018-10-30
CN109069430A (zh) 2018-12-21
EP3429560A1 (en) 2019-01-23
GEAP202214903A (en) 2022-06-27
EA201892065A1 (ru) 2019-04-30
CN109069430B (zh) 2022-09-23
GEP20227445B (en) 2022-12-12
HRP20250187T1 (hr) 2025-04-25
MY196575A (en) 2023-04-19
KR20190006946A (ko) 2019-01-21
HUE070063T2 (hu) 2025-05-28
EP3429560B1 (en) 2024-12-25
IL261735B (en) 2022-07-01
SA518400019B1 (ar) 2022-12-11
KR102403292B1 (ko) 2022-05-27
MX2018011227A (es) 2019-05-16
CR20180488A (es) 2019-03-12
EP3429560C0 (en) 2024-12-25
MA43703A (fr) 2018-11-28
UA125211C2 (uk) 2022-02-02
US20190054115A1 (en) 2019-02-21
CU20180108A7 (es) 2019-09-04
ES3008084T3 (en) 2025-03-21
CL2018002632A1 (es) 2019-03-15
AU2017232266B2 (en) 2022-10-06
WO2017158030A1 (en) 2017-09-21
PH12018501994A1 (en) 2019-06-17
CA3017556C (en) 2023-12-05
PL3429560T3 (pl) 2025-04-28

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