ECSP19085444A - Anticuerpo anti-receptor de igf-1 - Google Patents
Anticuerpo anti-receptor de igf-1Info
- Publication number
- ECSP19085444A ECSP19085444A ECSENADI201985444A ECDI201985444A ECSP19085444A EC SP19085444 A ECSP19085444 A EC SP19085444A EC SENADI201985444 A ECSENADI201985444 A EC SENADI201985444A EC DI201985444 A ECDI201985444 A EC DI201985444A EC SP19085444 A ECSP19085444 A EC SP19085444A
- Authority
- EC
- Ecuador
- Prior art keywords
- igf
- receptor antibody
- vertebrate
- receptor
- fragment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1323—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from skeletal muscle cells
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Abstract
En la presente se proporciona un anticuerpo antireceptor de IGF-I o su fragmento o un derivado del mismo que se une específicamente a un receptor de IGF-I de un vertebrado y exhibe una actividad de inducción del crecimiento de células derivadas de vertebrado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017106529 | 2017-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP19085444A true ECSP19085444A (es) | 2019-12-27 |
Family
ID=64456280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201985444A ECSP19085444A (es) | 2017-05-30 | 2019-11-29 | Anticuerpo anti-receptor de igf-1 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11629194B2 (es) |
| EP (1) | EP3636670A4 (es) |
| JP (2) | JP6987136B2 (es) |
| KR (3) | KR102904897B1 (es) |
| CN (1) | CN110691794B (es) |
| AR (1) | AR112600A1 (es) |
| AU (1) | AU2018276554B2 (es) |
| BR (1) | BR112019022789A2 (es) |
| CA (1) | CA3056573A1 (es) |
| CL (1) | CL2019003490A1 (es) |
| CO (1) | CO2019013381A2 (es) |
| EC (1) | ECSP19085444A (es) |
| IL (1) | IL270971B2 (es) |
| MX (1) | MX2019014174A (es) |
| MY (1) | MY199751A (es) |
| PH (1) | PH12019502704A1 (es) |
| TW (1) | TWI877098B (es) |
| WO (1) | WO2018221521A1 (es) |
| ZA (1) | ZA201906917B (es) |
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| CN110691794B (zh) * | 2017-05-30 | 2023-10-27 | 帝人制药株式会社 | 抗igf-i受体抗体 |
| AU2019393487A1 (en) * | 2018-12-03 | 2021-06-03 | Teijin Pharma Limited | Anti-IGF-I receptor humanized antibody |
| CN109943529A (zh) * | 2019-03-21 | 2019-06-28 | 北京市朝阳区妇幼保健院 | 一种牛磺酸对iugr胎鼠神经元增殖的应用方法 |
| CN110156891B (zh) * | 2019-04-03 | 2020-04-28 | 浙江众意生物科技有限公司 | 一种高效、快速结合vegf的抗体及其用途 |
| IL296519A (en) | 2020-06-02 | 2022-11-01 | Teijin Pharma Ltd | Anti-igf-1 receptor humanized antibody |
| CR20230204A (es) | 2020-10-14 | 2023-10-11 | Viridian Therapeutics Inc | Composiciones y métodos para el tratamiento de la enfermedad ocular tiroidea |
| TW202320850A (zh) | 2021-08-10 | 2023-06-01 | 美商維里迪恩醫療股份有限公司 | 用於治療甲狀腺眼病之組合物、劑量及方法 |
| JP7707834B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707829B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707830B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707832B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707831B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707823B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707820B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707825B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707833B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
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| JP7707836B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707821B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707822B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707827B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707828B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707826B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| CN116785312B (zh) * | 2023-06-21 | 2023-11-14 | 天津医科大学眼科医院 | miR-15a-5p在治疗眼底疾病中的应用 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ras抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ras抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
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| CA2405504A1 (en) | 2000-04-24 | 2001-11-15 | Wyeth | Transgenic animal |
| AU2004303792A1 (en) * | 2003-12-08 | 2005-07-07 | Immunogen, Inc. | Anti-IGF-I receptor antibody |
| JP2004357612A (ja) | 2003-06-05 | 2004-12-24 | Institute Of Physical & Chemical Research | Fgfシグナル伝達に関与する遺伝子 |
| MY146381A (en) * | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| US8301398B2 (en) * | 2006-06-22 | 2012-10-30 | Walter And Eliza Hall Institute Of Medical Research | Structure of the insulin receptor ectodomain |
| US20090130105A1 (en) | 2007-08-28 | 2009-05-21 | Biogen Idec Ma Inc. | Compositions that bind multiple epitopes of igf-1r |
| RU2010144014A (ru) | 2008-04-03 | 2012-05-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Применение пегилированных вариантов ифр-i для лечения нейромышечных расстройств |
| TWI777183B (zh) | 2012-05-31 | 2022-09-11 | 公立大學法人大阪市立大學 | 失智症治療劑或預防劑 |
| CN110691794B (zh) * | 2017-05-30 | 2023-10-27 | 帝人制药株式会社 | 抗igf-i受体抗体 |
-
2018
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- 2018-05-29 WO PCT/JP2018/020581 patent/WO2018221521A1/ja not_active Ceased
- 2018-05-29 CA CA3056573A patent/CA3056573A1/en active Pending
- 2018-05-29 EP EP18808756.3A patent/EP3636670A4/en active Pending
- 2018-05-29 US US16/610,396 patent/US11629194B2/en active Active
- 2018-05-29 TW TW107118252A patent/TWI877098B/zh active
- 2018-05-29 IL IL270971A patent/IL270971B2/en unknown
- 2018-05-29 BR BR112019022789A patent/BR112019022789A2/pt unknown
- 2018-05-29 MY MYPI2019006264A patent/MY199751A/en unknown
- 2018-05-29 MX MX2019014174A patent/MX2019014174A/es unknown
- 2018-05-29 KR KR1020237042686A patent/KR102904897B1/ko active Active
- 2018-05-29 AU AU2018276554A patent/AU2018276554B2/en active Active
- 2018-05-29 AR ARP180101412 patent/AR112600A1/es unknown
- 2018-05-29 JP JP2019521238A patent/JP6987136B2/ja active Active
- 2018-05-29 KR KR1020197033242A patent/KR20190138672A/ko not_active Ceased
- 2018-05-29 KR KR1020227011819A patent/KR20220051270A/ko not_active Ceased
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2019
- 2019-10-21 ZA ZA2019/06917A patent/ZA201906917B/en unknown
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- 2019-11-28 CL CL2019003490A patent/CL2019003490A1/es unknown
- 2019-11-28 PH PH12019502704A patent/PH12019502704A1/en unknown
- 2019-11-29 EC ECSENADI201985444A patent/ECSP19085444A/es unknown
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2021
- 2021-06-08 JP JP2021096162A patent/JP7798489B2/ja active Active
-
2023
- 2023-03-02 US US18/177,718 patent/US20230192868A1/en not_active Abandoned
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