ECSP20070854A - Compuestos heteroaril tetracíclicos - Google Patents
Compuestos heteroaril tetracíclicosInfo
- Publication number
- ECSP20070854A ECSP20070854A ECSENADI202070854A ECDI202070854A ECSP20070854A EC SP20070854 A ECSP20070854 A EC SP20070854A EC SENADI202070854 A ECSENADI202070854 A EC SENADI202070854A EC DI202070854 A ECDI202070854 A EC DI202070854A EC SP20070854 A ECSP20070854 A EC SP20070854A
- Authority
- EC
- Ecuador
- Prior art keywords
- heteroaryl
- tetracyclic compounds
- compounds
- refers
- tetracyclic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La memoria descriptiva se refiere a compuestos de Fórmula (I) y sales farmacéuticamente aceptables de los mismos. La memoria descriptiva también se refiere a procesos e intermedios usados para su preparación, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos proliferativos celulares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862668321P | 2018-05-08 | 2018-05-08 | |
| US201862754814P | 2018-11-02 | 2018-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP20070854A true ECSP20070854A (es) | 2020-12-31 |
Family
ID=66484036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202070854A ECSP20070854A (es) | 2018-05-08 | 2020-11-06 | Compuestos heteroaril tetracíclicos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11407765B2 (es) |
| EP (1) | EP3790884A1 (es) |
| JP (1) | JP7138724B2 (es) |
| KR (1) | KR20210006948A (es) |
| CN (1) | CN112074520A (es) |
| AU (1) | AU2019267008B2 (es) |
| BR (1) | BR112020021467A2 (es) |
| CA (1) | CA3098261A1 (es) |
| CL (1) | CL2020002866A1 (es) |
| CO (1) | CO2020013564A2 (es) |
| CR (1) | CR20200532A (es) |
| DO (1) | DOP2020000201A (es) |
| EC (1) | ECSP20070854A (es) |
| JO (1) | JOP20200281A1 (es) |
| MA (1) | MA52560A (es) |
| MX (1) | MX2020011910A (es) |
| NI (1) | NI202000078A (es) |
| PE (1) | PE20211795A1 (es) |
| PH (1) | PH12020551870A1 (es) |
| SG (1) | SG11202010953QA (es) |
| TW (1) | TW202012415A (es) |
| UY (1) | UY38221A (es) |
| WO (1) | WO2019215203A1 (es) |
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| WO2018140600A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused hetero-hetero bicyclic compounds and methods of use thereof |
| JP2020505395A (ja) | 2017-01-26 | 2020-02-20 | アラクセス ファーマ エルエルシー | 縮合ｎ−複素環式化合物およびその使用方法 |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| JOP20190186A1 (ar) | 2017-02-02 | 2019-08-01 | Astellas Pharma Inc | مركب كينازولين |
| WO2018206539A1 (en) | 2017-05-11 | 2018-11-15 | Astrazeneca Ab | Heteroaryl compounds that inhibit g12c mutant ras proteins |
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| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
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| ES2928576T3 (es) | 2017-09-08 | 2022-11-21 | Amgen Inc | Inhibidores de KRAS G12C y métodos de uso de los mismos |
| PT3710439T (pt) | 2017-11-15 | 2023-05-15 | Array Biopharma Inc | Inibidores de kras g12c |
| WO2019110751A1 (en) | 2017-12-08 | 2019-06-13 | Astrazeneca Ab | Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents |
| TW201942115A (zh) | 2018-02-01 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物 |
| TW201942116A (zh) | 2018-02-09 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌劑之四氫喹唑啉衍生物 |
-
2019
- 2019-05-03 TW TW108115329A patent/TW202012415A/zh unknown
- 2019-05-07 US US17/053,400 patent/US11407765B2/en active Active
- 2019-05-07 PE PE2020001766A patent/PE20211795A1/es unknown
- 2019-05-07 AU AU2019267008A patent/AU2019267008B2/en not_active Expired - Fee Related
- 2019-05-07 JP JP2020560800A patent/JP7138724B2/ja active Active
- 2019-05-07 CA CA3098261A patent/CA3098261A1/en active Pending
- 2019-05-07 SG SG11202010953QA patent/SG11202010953QA/en unknown
- 2019-05-07 JO JOP/2020/0281A patent/JOP20200281A1/ar unknown
- 2019-05-07 BR BR112020021467-1A patent/BR112020021467A2/pt not_active Application Discontinuation
- 2019-05-07 EP EP19723368.7A patent/EP3790884A1/en not_active Withdrawn
- 2019-05-07 KR KR1020207035034A patent/KR20210006948A/ko not_active Withdrawn
- 2019-05-07 CR CR20200532A patent/CR20200532A/es unknown
- 2019-05-07 WO PCT/EP2019/061754 patent/WO2019215203A1/en not_active Ceased
- 2019-05-07 MX MX2020011910A patent/MX2020011910A/es unknown
- 2019-05-07 MA MA052560A patent/MA52560A/fr unknown
- 2019-05-07 CN CN201980030143.8A patent/CN112074520A/zh active Pending
- 2019-05-08 UY UY38221A patent/UY38221A/es not_active Application Discontinuation
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2020
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- 2020-11-05 CL CL2020002866A patent/CL2020002866A1/es unknown
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Also Published As
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|---|---|
| CN112074520A (zh) | 2020-12-11 |
| MA52560A (fr) | 2021-03-17 |
| DOP2020000201A (es) | 2020-11-30 |
| CO2020013564A2 (es) | 2020-11-10 |
| PE20211795A1 (es) | 2021-09-09 |
| TW202012415A (zh) | 2020-04-01 |
| JP2021532061A (ja) | 2021-11-25 |
| US20210221823A1 (en) | 2021-07-22 |
| CR20200532A (es) | 2020-12-23 |
| KR20210006948A (ko) | 2021-01-19 |
| UY38221A (es) | 2019-10-31 |
| CL2020002866A1 (es) | 2021-02-12 |
| AU2019267008A1 (en) | 2021-01-07 |
| AU2019267008B2 (en) | 2022-02-17 |
| BR112020021467A2 (pt) | 2021-01-19 |
| MX2020011910A (es) | 2021-01-29 |
| US11407765B2 (en) | 2022-08-09 |
| EP3790884A1 (en) | 2021-03-17 |
| PH12020551870A1 (en) | 2021-07-26 |
| JP7138724B2 (ja) | 2022-09-16 |
| WO2019215203A1 (en) | 2019-11-14 |
| JOP20200281A1 (ar) | 2020-11-05 |
| CA3098261A1 (en) | 2019-11-14 |
| SG11202010953QA (en) | 2020-12-30 |
| NI202000078A (es) | 2021-02-16 |
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