ECSP20080995A - Derivados de tetrahidrotienopiridina n–sustituidos y sus usos - Google Patents

Derivados de tetrahidrotienopiridina n–sustituidos y sus usos

Info

Publication number
ECSP20080995A
ECSP20080995A ECSENADI202080995A ECDI202080995A ECSP20080995A EC SP20080995 A ECSP20080995 A EC SP20080995A EC SENADI202080995 A ECSENADI202080995 A EC SENADI202080995A EC DI202080995 A ECDI202080995 A EC DI202080995A EC SP20080995 A ECSP20080995 A EC SP20080995A
Authority
EC
Ecuador
Prior art keywords
substituted
tetrahydrothienopyridine derivatives
derivatives
substituted tetrahydrothienopyridine
useful
Prior art date
Application number
ECSENADI202080995A
Other languages
English (en)
Inventor
Wei Lin Sandra Sim
Fumiaki Yokokawa
Hui Quan Yeo
Bin Zou
Gang Wang
Bryan Ks Yeung
Cyrille Kounde
Oliver Simon
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67841114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP20080995(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP20080995A publication Critical patent/ECSP20080995A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporciona un compuesto de Fórmula (I) que ha demostrado ser útil para el tratamiento de una enfermedad causada por una infección viral:(I) en donde R1, R2, R3, A, L, m, n, p y q son como se definen en la presente memoria.
ECSENADI202080995A 2018-06-19 2020-12-15 Derivados de tetrahidrotienopiridina n–sustituidos y sus usos ECSP20080995A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862687068P 2018-06-19 2018-06-19

Publications (1)

Publication Number Publication Date
ECSP20080995A true ECSP20080995A (es) 2021-02-26

Family

ID=67841114

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202080995A ECSP20080995A (es) 2018-06-19 2020-12-15 Derivados de tetrahidrotienopiridina n–sustituidos y sus usos

Country Status (24)

Country Link
US (3) US12012417B2 (es)
EP (2) EP4169925B1 (es)
JP (1) JP7328260B2 (es)
KR (1) KR102835904B1 (es)
CN (1) CN112313237A (es)
AU (1) AU2019291488B2 (es)
BR (1) BR112020025696A2 (es)
CA (1) CA3100957A1 (es)
CL (1) CL2020003248A1 (es)
CR (1) CR20200618A (es)
CU (1) CU20200100A7 (es)
EA (1) EA202190046A1 (es)
EC (1) ECSP20080995A (es)
ES (1) ES2941946T3 (es)
IL (1) IL279441B2 (es)
JO (1) JOP20200326A1 (es)
MA (1) MA52976A (es)
MX (1) MX2020013852A (es)
MY (1) MY201990A (es)
PE (1) PE20210097A1 (es)
PH (1) PH12020552185A1 (es)
SA (1) SA520420809B1 (es)
SG (1) SG11202012625PA (es)
WO (1) WO2019244047A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110945002B (zh) * 2017-08-01 2021-12-24 正大天晴药业集团股份有限公司 作为RORγ抑制剂的双环化合物
EP4169925B1 (en) 2018-06-19 2025-11-19 Novartis AG Process to make n-substituted tetrahydrothienopyridine derivatives
USD1006154S1 (en) * 2023-06-27 2023-11-28 Qiongfang Mao Cable crossover attachment
WO2025238553A1 (en) 2024-05-14 2025-11-20 Novartis Ag Dosing regimens for n-(3-cyano-5-(cyclohexylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide for use in treating or preventing a dengue virus disease or disorder
WO2025253267A1 (en) 2024-06-06 2025-12-11 Janssen Pharmaceuticals, Inc. Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US54472A (en) 1866-05-01 Improved blacking-brush
US5807A (en) 1848-09-26 Brake fob cabs
US8766A (en) 1852-02-24 Appabatus for lightening vessels
US6344A (en) 1849-04-17 Driving-bobbin
US4656A (en) 1846-07-24 Improvement in potato-plows
US498178A (en) 1893-05-23 William valentine leonard
US6054472A (en) 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
TR199802136T2 (xx) 1996-04-23 2001-06-21 Vertex Pharmaceuticals Incorporated �MPDH enzimi inhibit�rleri olarak �re t�revleri.
ATE244717T1 (de) 1997-03-14 2003-07-15 Vertex Pharma Inhibitoren des impdh-enzyms
ES2405316T3 (es) 1999-03-19 2013-05-30 Vertex Pharmaceuticals Incorporated Inhibidores de la enzima IMPDH
GB0114185D0 (en) 2001-06-12 2001-08-01 Protherics Molecular Design Lt Compounds
CA2447897A1 (en) 2001-05-21 2002-12-27 Monsanto Technology Llc Pesticide concentrates containing etheramine surfactants
US20030232994A1 (en) 2001-10-04 2003-12-18 Shao-Po Lu Bicyclic thiophene derivatives and combinatorial libraries thereof
CA2498399A1 (en) 2002-09-12 2004-03-25 Merck & Co., Inc. Method of treating diabetes and related conditions
US7138529B2 (en) * 2003-04-16 2006-11-21 Hoffmann-La Roche Inc. Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
GB0324653D0 (en) 2003-10-22 2003-11-26 Syngenta Participations Ag Fungicides
PL1753512T3 (pl) 2004-05-28 2009-03-31 4Sc Ag Tetrahydropirydotiofeny
US20060034831A1 (en) 2004-08-12 2006-02-16 Wyeth Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors
EP1851229A1 (en) 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
WO2006084904A1 (en) 2005-02-11 2006-08-17 Nycomed Gmbh Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
US7569600B2 (en) 2005-05-13 2009-08-04 Virochem Pharma Inc. Compounds and methods for the treatment of prevention of Flavivirus infections
JP2008542243A (ja) 2005-05-25 2008-11-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のテトラヒドロピリドチオフェン
JP2008542242A (ja) 2005-05-25 2008-11-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のテトラヒドロピリドチオフェン
US7932391B2 (en) 2005-09-08 2011-04-26 Zhejiang Hauhai Pharmaceutical Co., Ltd. Method for the preparation of clopidogrel and its analogues of methyl-tetrahydrothieno[3,2-C]pyridine acetate
JP2010500395A (ja) 2006-08-16 2010-01-07 ４エスツェー アクチェンゲゼルシャフト 癌治療のためのテトラヒドロピリドチオフェン誘導体
CA2660604A1 (en) 2006-08-16 2008-02-21 4Sc Ag Tetrahydrobenzothiophene derivatives
WO2008067222A1 (en) 2006-11-28 2008-06-05 Kalypsys, Inc. Heterocyclic modulators of tgr5
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2010099166A1 (en) * 2009-02-27 2010-09-02 Siga Technologies, Inc. Thienopyridine derivatives for the treatment and prevention of dengue virus infections
US20130129677A1 (en) 2009-02-27 2013-05-23 Siga Technologies, Inc. Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections
JP5701655B2 (ja) * 2011-03-29 2015-04-15 奈良県 植物精油中のトロポロン類及び／又はフェノール類の金属錯体化方法
JP2014528412A (ja) 2011-09-30 2014-10-27 キネタ・インコーポレイテツド 抗ウイルス化合物
US10844051B2 (en) 2015-07-22 2020-11-24 The Royal Institution For The Advancement Of Learning/Mcgill University Substituted oxazoles for the treatment of cancer
CN108689987A (zh) * 2017-04-05 2018-10-23 浙江海正药业股份有限公司 一种磺胺类衍生物及其制备方法和用途
PE20200342A1 (es) 2017-05-22 2020-02-14 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
CN110945002B (zh) 2017-08-01 2021-12-24 正大天晴药业集团股份有限公司 作为RORγ抑制剂的双环化合物
CN108191885B (zh) * 2018-01-29 2020-08-04 华东师范大学 一类哌啶并噻吩类小分子有机化合物及其应用
EP4169925B1 (en) 2018-06-19 2025-11-19 Novartis AG Process to make n-substituted tetrahydrothienopyridine derivatives

Also Published As

Publication number Publication date
PH12020552185A1 (en) 2021-06-07
US20220073535A1 (en) 2022-03-10
KR20210022645A (ko) 2021-03-03
CU20200100A7 (es) 2021-08-06
EP4169925A2 (en) 2023-04-26
EP3810613B1 (en) 2023-01-11
EP4169925A3 (en) 2023-06-14
AU2019291488A1 (en) 2021-02-04
ES2941946T3 (es) 2023-05-26
JOP20200326A1 (ar) 2020-12-14
EP4169925B1 (en) 2025-11-19
PE20210097A1 (es) 2021-01-12
CN112313237A (zh) 2021-02-02
SG11202012625PA (en) 2021-01-28
AU2019291488B2 (en) 2022-02-24
EP3810613A1 (en) 2021-04-28
MX2020013852A (es) 2021-05-27
MA52976A (fr) 2021-04-28
MY201990A (en) 2024-03-27
JP7328260B2 (ja) 2023-08-16
WO2019244047A1 (en) 2019-12-26
IL279441B2 (en) 2023-06-01
CL2020003248A1 (es) 2021-07-09
US12012417B2 (en) 2024-06-18
CR20200618A (es) 2021-01-21
JP2021529159A (ja) 2021-10-28
US20240352030A1 (en) 2024-10-24
SA520420809B1 (ar) 2022-08-17
US20260070920A1 (en) 2026-03-12
CA3100957A1 (en) 2019-12-26
US12331060B2 (en) 2025-06-17
IL279441A (en) 2021-01-31
BR112020025696A2 (pt) 2021-03-16
KR102835904B1 (ko) 2025-07-22
EA202190046A1 (ru) 2021-03-24

Similar Documents

Publication Publication Date Title
ECSP20080995A (es) Derivados de tetrahidrotienopiridina n–sustituidos y sus usos
CY1125004T1 (el) Ετεροαρυλο υποκατεστημενες βητα-υδροξυαιθυλαμινες για χρηση στη θεραπεια της υπεργλυκαιμιας
UY35155A (es) Derivados cíclicos de nucleósidos y usos de los mismos
CO2019000932A2 (es) Nuevos compuestos sulfonimidoilpurinona 7-sustituidos y derivados para el tratamiento y la profilaxis de la infección vírica.
DOP2017000149A (es) Compuestos de triazolopirimidina y usos de los mismos
ECSP15018618A (es) Inhibidores no nucleósidos de la transcriptasa inversa
MX379474B (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales
CO2017007355A2 (es) Compuestos derivados de pirazincarbozamida y de pirazincarboxilato para el tratamiento de la infección por el virus de hepatitis b
CO2019005534A2 (es) Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih
MX2020010949A (es) Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones viricas.
UY37774A (es) Compuestos 5-cianoindol sustituidos y usos de los mismos
UY35305A (es) Compuestos sustituidos como moduladores de la pro teína de activación de la 5-lipoxigenasa (flap)
DOP2016000308A (es) Compuestos de 1, 3, 4-tiadiazol y uso de los mismos para el tratamiento del cáncer
MX2018003311A (es) Ácido nucleico artificial puenteado a guanidina, entrelazado, método para la producción del mismo, y compuesto intermediario.
MX2019003026A (es) Compuestos de heteroarilcarboxamida como inhibidores de ripk2.
CR20170035A (es) Compuestos de imidazopiridazina
MX2022015151A (es) Procesos para preparar acido 3-(3-(3,5-dimetil-1h-pirazol-4-il)pro poxi)-4- 5-fluorobenzoico (ag-10), sus compuestos intermedios, y sales del mismo.
CR20180615A (es) Nuevos derivados de [1,2,3]triazol[4,5-d]pirimidina
DOP2019000102A (es) Constructos de vacuna y sus usos contra infecciones causadas por staphylococcus
UY37641A (es) Compuestos de isoxazol carboxamida y usos de los mismos
CU24716B1 (es) FORMA POLIMÓRFICA ESTABLE DE 6-FLUORO-9-METIL-9H-ß-CARBOLINA
UY35627A (es) Derivados de 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hidroxiprop-1-il)-4-metoxi-3-(fenilsulfonilmetil)tetrahidrofuran-2-il)acetaldehido y procedimiento para su preparacion.