ECSP21036982A - DERIVATIVES OF AMINO TRIAZOLO QUINAZOLINE 9-SUBSTITUTED AS ANTAGONISTS OF THE ADENOSINE RECEPTOR, PHARMACEUTICAL COMPOSITIONS AND THEIR USE - Google Patents

DERIVATIVES OF AMINO TRIAZOLO QUINAZOLINE 9-SUBSTITUTED AS ANTAGONISTS OF THE ADENOSINE RECEPTOR, PHARMACEUTICAL COMPOSITIONS AND THEIR USE

Info

Publication number
ECSP21036982A
ECSP21036982A ECSENADI202136982A ECDI202136982A ECSP21036982A EC SP21036982 A ECSP21036982 A EC SP21036982A EC SENADI202136982 A ECSENADI202136982 A EC SENADI202136982A EC DI202136982 A ECDI202136982 A EC DI202136982A EC SP21036982 A ECSP21036982 A EC SP21036982A
Authority
EC
Ecuador
Prior art keywords
pharmaceutical compositions
quinazoline
antagonists
substituted
derivatives
Prior art date
Application number
ECSENADI202136982A
Other languages
Spanish (es)
Inventor
Jared Cumming
Kun Liu
Umar Faruk Mansoor
Uma Swaminathan
Jianping Pan
Matthew Larsen
Andrew Hoover
Qiaolin Deng
Duane Demong
Huijun Wang
Elisabeth Hennessy
Ping Liu
Yonglian Zhang
Christopher Plummer
Aaron Sather
Amjad Ali
Thomas Graham
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69005832&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP21036982(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ECSP21036982A publication Critical patent/ECSP21036982A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En su gran cantidad de formas de realización, la presente invención proporciona determinados compuestos de amino triazolo quinazolina 9-sustituidos de la Fórmula estructural (I), que consta en el resumen de la memoria técnica, y sales de aquellos farmacéuticamente aceptables, en donde el anillo A, R1 y R2 son como se definen en la presente, composiciones farmacéuticas que comprenden uno o más de estos compuestos (solos o en combinación con uno o más agentes terapéuticamente activos diferentes), y métodos para su preparación y uso, solos o en combinación con otros agentes terapéuticos, como antagonistas de receptores A2a y/o A2b, y en el tratamiento de diversas enfermedades, afecciones o trastornos que están mediadas, al menos en parte, por el receptor de adenosina A2a y/o el receptor de adenosina A2b.In its large number of embodiments, the present invention provides certain 9-substituted amino triazolo quinazoline compounds of structural Formula (I), which is contained in the abstract of the technical specification, and salts of those pharmaceutically acceptable, wherein the Ring A, R1 and R2 are as defined herein, pharmaceutical compositions comprising one or more of these compounds (alone or in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone or in combination with other therapeutic agents, such as A2a and / or A2b receptor antagonists, and in the treatment of various diseases, conditions or disorders that are mediated, at least in part, by the adenosine A2a receptor and / or the adenosine A2b receptor .

ECSENADI202136982A 2018-11-30 2021-05-25 DERIVATIVES OF AMINO TRIAZOLO QUINAZOLINE 9-SUBSTITUTED AS ANTAGONISTS OF THE ADENOSINE RECEPTOR, PHARMACEUTICAL COMPOSITIONS AND THEIR USE ECSP21036982A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862774077P 2018-11-30 2018-11-30

Publications (1)

Publication Number Publication Date
ECSP21036982A true ECSP21036982A (en) 2021-06-30

Family

ID=69005832

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202136982A ECSP21036982A (en) 2018-11-30 2021-05-25 DERIVATIVES OF AMINO TRIAZOLO QUINAZOLINE 9-SUBSTITUTED AS ANTAGONISTS OF THE ADENOSINE RECEPTOR, PHARMACEUTICAL COMPOSITIONS AND THEIR USE

Country Status (25)

Country Link
US (2) US11312719B2 (en)
EP (1) EP3886988A1 (en)
JP (1) JP7241871B2 (en)
KR (1) KR102653800B1 (en)
CN (1) CN113329791A (en)
AR (1) AR117164A1 (en)
AU (1) AU2019385905B2 (en)
BR (1) BR112021010427B1 (en)
CA (1) CA3120862C (en)
CL (1) CL2021001406A1 (en)
CO (1) CO2021006888A2 (en)
CR (1) CR20210271A (en)
DO (1) DOP2021000104A (en)
EA (1) EA202191498A1 (en)
EC (1) ECSP21036982A (en)
IL (1) IL283334A (en)
JO (2) JOP20210117A1 (en)
MA (1) MA54298A (en)
MX (1) MX2021006329A (en)
NI (1) NI202100043A (en)
PE (1) PE20211768A1 (en)
PH (1) PH12021551196A1 (en)
SG (1) SG11202105180PA (en)
TW (1) TW202039496A (en)
WO (1) WO2020112700A1 (en)

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EP4626892A1 (en) * 2022-11-29 2025-10-08 Merck Sharp & Dohme LLC Adenosine a2a and a2b receptor antagonists, pharmaceutical compositions and use thereof
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MX2021006329A (en) 2021-08-11
KR102653800B1 (en) 2024-04-01
EA202191498A1 (en) 2021-08-20
JOP20210117A1 (en) 2023-01-30
CN113329791A (en) 2021-08-31
IL283334A (en) 2021-07-29
PH12021551196A1 (en) 2021-11-29
AR117164A1 (en) 2021-07-14
TW202039496A (en) 2020-11-01
KR20210096184A (en) 2021-08-04
BR112021010427B1 (en) 2022-09-27
CA3120862C (en) 2024-05-07
AU2019385905A1 (en) 2021-06-03
CL2021001406A1 (en) 2021-11-12
NI202100043A (en) 2021-08-13
MA54298A (en) 2022-03-09
CA3120862A1 (en) 2020-06-04
CO2021006888A2 (en) 2021-06-10
JOP20210116A1 (en) 2023-01-30
US11312719B2 (en) 2022-04-26
BR112021010427A2 (en) 2021-08-17
SG11202105180PA (en) 2021-06-29
AU2019385905B2 (en) 2023-01-12
US20210107904A1 (en) 2021-04-15
CR20210271A (en) 2021-07-14
JP7241871B2 (en) 2023-03-17
JP2022511441A (en) 2022-01-31
US20220220117A1 (en) 2022-07-14
EP3886988A1 (en) 2021-10-06
WO2020112700A1 (en) 2020-06-04
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