ECSP21039816A - Anticuerpos monoclonales antirrábicos y cóctel de estos - Google Patents

Anticuerpos monoclonales antirrábicos y cóctel de estos

Info

Publication number
ECSP21039816A
ECSP21039816A ECSENADI202139816A ECDI202139816A ECSP21039816A EC SP21039816 A ECSP21039816 A EC SP21039816A EC SENADI202139816 A ECSENADI202139816 A EC SENADI202139816A EC DI202139816 A ECDI202139816 A EC DI202139816A EC SP21039816 A ECSP21039816 A EC SP21039816A
Authority
EC
Ecuador
Prior art keywords
rabies
cocktail
monoclonal antibodies
disclosure provides
monoclonal antibody
Prior art date
Application number
ECSENADI202139816A
Other languages
English (en)
Inventor
Sanjay Bandyopadhyay
Sanjeev Kumar Mendiratta
Pankaj Kalita
Kevinkumar Kansagra
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of ECSP21039816A publication Critical patent/ECSP21039816A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La descripción proporciona un anticuerpo monoclonal murino capaz de unirse y neutralizar la rabia o virus relacionados con la rabia. También proporciona un cóctel de al menos dos anticuerpos monoclonales con dichas propiedades. El cóctel puede neutralizar el virus que se deriva de especies tales como murciélagos, perros, vacas, mangostas, zorrillos y lobos y, por lo tanto, puede ser útil para tratar un paciente que potencialmente ha sido infectado. Además, la descripción proporciona una combinación de anticuerpo monoclonal murino o cóctel de al menos dos anticuerpos monoclonales y vacuna antirrábica para su uso en la profilaxis posexposición (PPE) a la rabia o virus relacionados con la rabia.
ECSENADI202139816A 2018-11-02 2021-06-02 Anticuerpos monoclonales antirrábicos y cóctel de estos ECSP21039816A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201821041598 2018-11-02

Publications (1)

Publication Number Publication Date
ECSP21039816A true ECSP21039816A (es) 2021-09-30

Family

ID=68655573

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202139816A ECSP21039816A (es) 2018-11-02 2021-06-02 Anticuerpos monoclonales antirrábicos y cóctel de estos

Country Status (9)

Country Link
EP (1) EP3873526B1 (es)
CN (1) CN113226372A (es)
BR (1) BR112021008240A2 (es)
EC (1) ECSP21039816A (es)
MA (1) MA54075A (es)
MX (1) MX2021005029A (es)
PE (1) PE20211056A1 (es)
PH (1) PH12021550987A1 (es)
WO (1) WO2020089742A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117771365B (zh) * 2023-12-07 2025-07-04 兰州生物制品研究所有限责任公司 一种抗狂犬病病毒组合单克隆抗体制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103998059B (zh) * 2011-09-30 2016-01-20 赛特瑞恩股份有限公司 用于中和狂犬病病毒的结合分子
DK3220947T3 (da) * 2014-11-18 2020-11-30 Humabs Biomed S A Antistoffer som potent neutraliserer rabiesvirus og øvrige lyssavirusser og anvendelser deraf
CA2995109A1 (en) * 2015-08-13 2017-02-16 University Of Massachusetts Human antibodies against rabies and uses thereof

Also Published As

Publication number Publication date
EP3873526B1 (en) 2024-09-04
EP3873526A1 (en) 2021-09-08
WO2020089742A1 (en) 2020-05-07
MX2021005029A (es) 2021-07-15
PE20211056A1 (es) 2021-06-07
MA54075A (fr) 2022-02-09
CN113226372A (zh) 2021-08-06
PH12021550987A1 (en) 2021-11-08
BR112021008240A2 (pt) 2021-10-26

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