ECSP22044525A - Terapia de combinaci?n que comprende un inhibidor de alk2 y un inhibidor de jak2 - Google Patents

Terapia de combinaci?n que comprende un inhibidor de alk2 y un inhibidor de jak2

Info

Publication number
ECSP22044525A
ECSP22044525A ECSENADI202244525A ECDI202244525A ECSP22044525A EC SP22044525 A ECSP22044525 A EC SP22044525A EC SENADI202244525 A ECSENADI202244525 A EC SENADI202244525A EC DI202244525 A ECDI202244525 A EC DI202244525A EC SP22044525 A ECSP22044525 A EC SP22044525A
Authority
EC
Ecuador
Prior art keywords
inhibitor
alk2
combination therapy
jak2
compounds
Prior art date
Application number
ECSENADI202244525A
Other languages
English (en)
Inventor
Michelle Pusey
Ying-Nan Pan Chen
Yaoyu Chen
Matthew C Stubbs
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP22044525A publication Critical patent/ECSP22044525A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En el presente documento se proporcionan compuestos, composiciones farmac?uticas que comprenden dichos compuestos y m?todos para usar dichos compuestos para tratar enfermedades o trastornos asociados con JAK2 y/o ALK2.
ECSENADI202244525A 2019-11-22 2022-06-03 Terapia de combinaci?n que comprende un inhibidor de alk2 y un inhibidor de jak2 ECSP22044525A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962939241P 2019-11-22 2019-11-22
US202062980562P 2020-02-24 2020-02-24
US202063035194P 2020-06-05 2020-06-05
US202063056768P 2020-07-27 2020-07-27

Publications (1)

Publication Number Publication Date
ECSP22044525A true ECSP22044525A (es) 2022-08-31

Family

ID=73699492

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202244525A ECSP22044525A (es) 2019-11-22 2022-06-03 Terapia de combinaci?n que comprende un inhibidor de alk2 y un inhibidor de jak2

Country Status (17)

Country Link
US (2) US11738026B2 (es)
EP (1) EP4061367A1 (es)
JP (1) JP7717065B2 (es)
KR (1) KR20220107213A (es)
CN (1) CN115038443A (es)
AU (1) AU2020388638A1 (es)
BR (1) BR112022009710A2 (es)
CA (1) CA3160312A1 (es)
CL (1) CL2022001325A1 (es)
CR (1) CR20220280A (es)
EC (1) ECSP22044525A (es)
IL (1) IL293085A (es)
MX (1) MX2022006176A (es)
PE (1) PE20230251A1 (es)
PH (1) PH12022551052A1 (es)
TW (1) TW202131926A (es)
WO (1) WO2021102258A1 (es)

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CA3117695A1 (en) 2018-10-26 2020-04-30 Keros Therapeutics, Inc. Crystal forms of an alk2 inhibitor
WO2021222875A1 (en) 2020-04-30 2021-11-04 Keros Therapeutics, Inc. Methods of using alk2 inhibitors
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CA3187767A1 (en) 2020-06-16 2021-12-23 Incyte Corporation Alk2 inhibitors for the treatment of anemia
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
US20250034148A1 (en) * 2021-11-02 2025-01-30 Keros Therapeutics, Inc. Methods of using alk2 inhibitors
CN116478145B (zh) * 2022-04-13 2024-02-02 杭州邦顺制药有限公司 Alk2激酶抑制剂

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Also Published As

Publication number Publication date
JP7717065B2 (ja) 2025-08-01
EP4061367A1 (en) 2022-09-28
CR20220280A (es) 2022-09-02
CN115038443A (zh) 2022-09-09
KR20220107213A (ko) 2022-08-02
MX2022006176A (es) 2022-08-17
PE20230251A1 (es) 2023-02-07
IL293085A (en) 2022-07-01
US11738026B2 (en) 2023-08-29
WO2021102258A1 (en) 2021-05-27
CL2022001325A1 (es) 2023-03-24
BR112022009710A2 (pt) 2022-08-09
US20240041887A1 (en) 2024-02-08
US20210154195A1 (en) 2021-05-27
CA3160312A1 (en) 2021-05-27
JP2023502742A (ja) 2023-01-25
PH12022551052A1 (en) 2023-05-29
TW202131926A (zh) 2021-09-01
AU2020388638A1 (en) 2022-06-30

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