ECSP22078861A - Derivado de arilo o heteroarilo - Google Patents

Derivado de arilo o heteroarilo

Info

Publication number
ECSP22078861A
ECSP22078861A ECSENADI202278861A ECDI202278861A ECSP22078861A EC SP22078861 A ECSP22078861 A EC SP22078861A EC SENADI202278861 A ECSENADI202278861 A EC SENADI202278861A EC DI202278861 A ECDI202278861 A EC DI202278861A EC SP22078861 A ECSP22078861 A EC SP22078861A
Authority
EC
Ecuador
Prior art keywords
formula
aryl
renal failure
heteroaryl derivative
compound
Prior art date
Application number
ECSENADI202278861A
Other languages
English (en)
Inventor
Asahi Kawana
Susumu Takeuchi
Ryan D White
Nagasree Chakka
Wei Zhao
Masaki Koshimizu
Kosuke Sasaki
Sakae Sugiyama
Takuya Yokosaka
Brett M Johnson
Shinnosuke Hosoda
Toshiyuki Kaneko
Akinobu Maruyama
Kunio Minamizono
Kenta Kato
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of ECSP22078861A publication Critical patent/ECSP22078861A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La invención se refiere a un compuesto representado por la fórmula (I) o una sal farmacológicamente aceptable del mismo como un compuesto que puede ser utilizado como un medicamento terapéutico o profiláctico para las enfermedades asociadas con TRPC6, tales como el síndrome nefrótico, nefropatía membranosa, insuficiencia renal aguda, sepsis, insuficiencia renal crónica, nefropatía diabética, hipertensión pulmonar, lesión pulmonar aguda, insuficiencia cardíaca, neoplasia y distrofia muscular. (En la fórmula, Ar1, Ar2, X1-X3, R1, R3, R7, R8, L1 y L2 son los definidos en la especificación).
ECSENADI202278861A 2020-04-16 2022-10-07 Derivado de arilo o heteroarilo ECSP22078861A (es)

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JPS5747915B2 (es) * 1974-04-17 1982-10-13
JPS58427B2 (ja) * 1974-07-25 1983-01-06 武田薬品工業株式会社 ４−（ピリジンカルボニル）フェニル−１，２，４−トリアゾ−ル誘導体の製造法
GB1518693A (en) * 1974-09-17 1978-07-19 Takeda Chemical Industries Ltd 1,2,4-triazole derivatives
US4315926A (en) * 1979-12-26 1982-02-16 Ciba-Geigy Corporation Dibenz[c,e]azepines
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20110383A1 (es) * 2008-09-08 2011-07-15 Boehringer Ingelheim Int Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a)
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WO2013045519A1 (en) * 2011-09-27 2013-04-04 Genfit Derivatives of 6-substituted triazolopyridazines as rev-erb agonists
WO2014016766A1 (en) 2012-07-25 2014-01-30 Glenmark Pharmaceuticals S.A. Guanidine derivatives as trpc modulators
WO2014192865A1 (ja) * 2013-05-30 2014-12-04 大日本住友製薬株式会社 フェニルピペラジン誘導体
CN104292233B (zh) 2014-10-09 2016-03-16 武汉大学 一种吡唑并[1,5-a]嘧啶衍生物及其抗肿瘤用途
WO2016149315A1 (en) * 2015-03-18 2016-09-22 E. I. Du Pont De Nemours And Company Substituted pyrimidinyloxy pyridine derivatives as herbicides
CN106317050B (zh) 2016-08-24 2018-11-23 烟台大学 一种苯基噻唑衍生物及其制备方法与应用
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CN112204017B (zh) * 2018-04-27 2024-08-20 国立大学法人大阪大学 苯并异噁唑化合物

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BR112022020245A2 (pt) 2022-11-22
TW202204321A (zh) 2022-02-01
AU2021255088A1 (en) 2022-11-10
US20230167073A1 (en) 2023-06-01
CL2022002838A1 (es) 2023-07-07
AR121846A1 (es) 2022-07-13
CR20220518A (es) 2023-05-16
WO2021210650A1 (ja) 2021-10-21
JPWO2021210650A1 (es) 2021-10-21
EP4137481A1 (en) 2023-02-22
KR102857795B1 (ko) 2025-09-12
IL296200A (en) 2022-11-01
JP7614185B2 (ja) 2025-01-15
PE20221837A1 (es) 2022-11-29
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