ECSP22094536A - Anticuerpos contra el sars-cov-2 y métodos de selección y uso de los mismos - Google Patents

Anticuerpos contra el sars-cov-2 y métodos de selección y uso de los mismos

Info

Publication number
ECSP22094536A
ECSP22094536A ECSENADI202294536A ECDI202294536A ECSP22094536A EC SP22094536 A ECSP22094536 A EC SP22094536A EC SENADI202294536 A ECSENADI202294536 A EC SENADI202294536A EC DI202294536 A ECDI202294536 A EC DI202294536A EC SP22094536 A ECSP22094536 A EC SP22094536A
Authority
EC
Ecuador
Prior art keywords
cov
methods
sars
selection
antibodies against
Prior art date
Application number
ECSENADI202294536A
Other languages
English (en)
Inventor
Qun Du
James Steinhardt
Mark Esser
Saravanan RAJAN
Yueh-Ming Loo
Ii Patrick Mctamney
Reena M Varkey
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of ECSP22094536A publication Critical patent/ECSP22094536A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente divulgación proporciona anticuerpos y fragmentos de unión a antígeno de los mismos que se unen específicamente a la proteína espicular del SARS-CoV-2 y métodos para elaborar y seleccionar los mismos. Los anticuerpos pueden usarse, por ejemplo, en la profilaxis, profilaxis posterior a la exposición o tratamiento de la infección por SARS-CoV-2. Los anticuerpos también se pueden usar para detectar la infección por SARS-CoV-2 en un sujeto.
ECSENADI202294536A 2020-05-17 2022-12-13 Anticuerpos contra el sars-cov-2 y métodos de selección y uso de los mismos ECSP22094536A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063026121P 2020-05-17 2020-05-17

Publications (1)

Publication Number Publication Date
ECSP22094536A true ECSP22094536A (es) 2023-01-31

Family

ID=76098926

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202294536A ECSP22094536A (es) 2020-05-17 2022-12-13 Anticuerpos contra el sars-cov-2 y métodos de selección y uso de los mismos

Country Status (20)

Country Link
US (2) US20210355196A1 (es)
EP (1) EP4153312A1 (es)
JP (1) JP2023528235A (es)
KR (1) KR20230010749A (es)
CN (1) CN115697491A (es)
AR (1) AR122111A1 (es)
AU (1) AU2021275361A1 (es)
BR (1) BR112022023088A2 (es)
CA (1) CA3182150A1 (es)
CL (1) CL2022003177A1 (es)
CO (1) CO2022017690A2 (es)
CR (1) CR20220646A (es)
EC (1) ECSP22094536A (es)
IL (1) IL297977A (es)
MX (1) MX2022014422A (es)
PE (1) PE20231376A1 (es)
PH (1) PH12022553106A1 (es)
TW (1) TW202208423A (es)
UY (1) UY39221A (es)
WO (1) WO2021233834A1 (es)

Families Citing this family (13)

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WO2021195418A1 (en) 2020-03-26 2021-09-30 Vanderbilt University Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
CR20220552A (es) 2020-04-02 2023-01-17 Regeneron Pharma Anticuerpos contra glicoproteína de espícula anti-sars-cov-2 y fragmentos de unión al antígeno
MX2022014598A (es) 2020-05-26 2023-03-31 Regeneron Pharma Anticuerpos anti-glicoproteína espicular sars-cov-2 y fragmentos de unión al antígeno.
CR20220660A (es) 2020-06-03 2023-02-17 Regeneron Pharma Métodos para tratar o prevenir infecciones por sars-cov2 y covid-19 con anticuerpos de glicoproteína espícular anti-sars-cov-2
IL300257A (en) * 2020-08-10 2023-03-01 Astrazeneca Uk Ltd SARS-COV-2 antibodies for the treatment and prevention of COVID-19
WO2022263638A1 (en) * 2021-06-17 2022-12-22 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
EP4370210A1 (en) 2021-07-14 2024-05-22 Regeneron Pharmaceuticals, Inc. Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments
WO2023141176A2 (en) * 2022-01-19 2023-07-27 Icahn School Of Medicine At Mount Sinai Neutralizing antibodies and antigen-binding fragments thereof against omicron and other coronavirus variants, and methods of making and using the same
TW202342510A (zh) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
CN115286712B (zh) * 2022-03-18 2024-09-27 北京百普赛斯医学检验实验室有限公司 新型冠状病毒Delta突变株特异性抗体及其应用
CR20240528A (es) 2022-04-29 2025-04-04 Astrazeneca Uk Ltd Anticuerpos contra el sars-cov-2 y métodos para utilizarlos
CN117659181A (zh) * 2022-09-06 2024-03-08 南特细胞公司 针对sars-cov-2刺突蛋白的肽治疗剂
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Also Published As

Publication number Publication date
UY39221A (es) 2021-12-31
EP4153312A1 (en) 2023-03-29
PE20231376A1 (es) 2023-09-07
KR20230010749A (ko) 2023-01-19
MX2022014422A (es) 2022-12-07
US20240182548A1 (en) 2024-06-06
JP2023528235A (ja) 2023-07-04
PH12022553106A1 (en) 2023-11-20
US20210355196A1 (en) 2021-11-18
CN115697491A (zh) 2023-02-03
CA3182150A1 (en) 2021-11-25
TW202208423A (zh) 2022-03-01
BR112022023088A2 (pt) 2022-12-20
CL2022003177A1 (es) 2023-07-28
AU2021275361A1 (en) 2023-01-19
CR20220646A (es) 2023-10-23
IL297977A (en) 2023-01-01
AR122111A1 (es) 2022-08-17
CO2022017690A2 (es) 2022-12-20
WO2021233834A1 (en) 2021-11-25

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