ECSP951412A - SEPARATION OF AMLODIPINE ENANTIOMERS - Google Patents
SEPARATION OF AMLODIPINE ENANTIOMERSInfo
- Publication number
- ECSP951412A ECSP951412A ECSP951412A ECSP951412A EC SP951412 A ECSP951412 A EC SP951412A EC SP951412 A ECSP951412 A EC SP951412A EC SP951412 A ECSP951412 A EC SP951412A
- Authority
- EC
- Ecuador
- Prior art keywords
- amlodipine
- separation
- isomers
- dmso
- enantiomers
- Prior art date
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical class CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical class OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
El invento se refiere a un procedimiento para la separación de los isómeros r-(+) y s-(-) de la amodipina a partir de sus mezclas, que comprende la reacción de la mezcla e isómeros con acido l- o -tartarico en un disolvente orgánico que contiene dimetil sulfoxido (dmso) suficiente para la precipitación de respectivamente un solvato de dmso de una sal de l-tartrato de la r-(+)-amlodipina, o un solvato de dmso de una sal de d-tartrato de la s-(-)-amlodipina.The invention relates to a process for separating the r - (+) and s - (-) isomers of amodipine from their mixtures, which comprises the reaction of the mixture and isomers with l- or -tartaric acid in an organic solvent containing dimethyl sulfoxide (dmso) sufficient for the precipitation of respectively a dmso solvate of a l-tartrate salt of r - (+) - amlodipine, or a dmso solvate of a d-tartrate salt of s - (-) - amlodipine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP951412 ECSP951412A (en) | 1995-03-23 | 1995-03-23 | SEPARATION OF AMLODIPINE ENANTIOMERS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP951412 ECSP951412A (en) | 1995-03-23 | 1995-03-23 | SEPARATION OF AMLODIPINE ENANTIOMERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP951412A true ECSP951412A (en) | 1996-05-10 |
Family
ID=42042057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP951412 ECSP951412A (en) | 1995-03-23 | 1995-03-23 | SEPARATION OF AMLODIPINE ENANTIOMERS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP951412A (en) |
-
1995
- 1995-03-23 EC ECSP951412 patent/ECSP951412A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2116737T3 (en) | SEPARATION OF AMLODIPINO ENANTIOMERS THROUGH THEIR DIASTEREOMERIC TARTRATES. | |
| GT199900043A (en) | HYDROXAMIDES OF THE ACID (4-ARILSULFONILAMINO) -TETRAHIDROPIRAN-4-CARBOXÍLICO. | |
| ES2165115T3 (en) | A PROCEDURE FOR THE PURIFICATION OF PHOSFATIDINILSERINE. | |
| ES2148820T3 (en) | DERIVATIVES OF 3-PIRAZOLCARBOXAMIDE WITH AFFINITY FOR THE CANABINOID RECEPTOR. | |
| ES8106722A1 (en) | A METHOD FOR THE PREPARATION OF PHTHALIMIDINE DERIVATIVES | |
| ATE244280T1 (en) | TRANSXANTHOPHYL ESTER CONCENTRATES OF INCREASED PURITY AND METHOD FOR THE PRODUCTION THEREOF | |
| ES2195121T3 (en) | USE OF A PHARMACEUTICALLY ACCEPTABLE SALT OF (3R, 2'R) -3 - ((CICLOPENTILHYDROXIFENILACETIL) OXI) -1,1-DIMETHYL PIRROLIDINY FOR THE PREPARATION OF A MEDICINAL PRODUCT. | |
| DE69215108D1 (en) | PHENYLALKANIC ACID DERIVATIVE, ITS PRODUCTION AND SEPARATION OF ITS OPTICAL ISOMERS | |
| BR0007643A (en) | Process for obtaining aspirin derivatives (nitroxymethyl) esters, and aspirin derivatives (hydroxymethyl) phenylethers | |
| ES2081226T3 (en) | PENTA FLUORETHANE PURIFICATION. | |
| ES2126581T3 (en) | DERIVATIVES OF 3- (PIPERAZINO-ALQUIL) INDOLL CONDENSED IN 1.7 POSITIONS, AS WELL AS PROCEDURE AND INTERMEDIATE PRODUCTS FOR ITS PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS. | |
| ECSP951412A (en) | SEPARATION OF AMLODIPINE ENANTIOMERS | |
| ES2193271T3 (en) | PROCEDURE FOR PREPARATION OF DERIVATIVES OF PHENYLIMIDAZOLIDINE. | |
| Narizuka et al. | Electrosynthesis of 4, 4-dimethyl-2-ethoxycarbonyl-5-fluoro-3-thiolanones: highly potent human type II PLA2 inhibitors | |
| BR9914607A (en) | Process for the production of bis (4-hydroxyaryl) alkanes | |
| ES2085497T3 (en) | PROCEDURE FOR THE PREPARATION OF THE ACID 1,2,3,4-TETRAHIDROISOQUINOLIN-3-CARBOXILICO RACEMICO AND OPTICALLY ACTIVE, AS WELL AS OF ITS PRECURSORS. | |
| CO4920247A1 (en) | PROCEDURE FOR THE SYNTHESIS OF BENZOTHIOPHENES | |
| DK0636607T3 (en) | Process for crystallization of methionine | |
| AR048274A1 (en) | STEREOSELECTIVE SYNTHESIS OF VITAMIN D ANALOGS | |
| ES2095992T3 (en) | PROCEDURE FOR THE SEPARATION OF ENANTIOMERS FROM 5-HETHARYL-1,3,4-TIADIAZINONE. | |
| DE19881543D2 (en) | Pressed chloramine T tablets and process for their manufacture | |
| BRPI0414715A (en) | process for the separation of alkyl branched c12ac24 fatty acids and mixture of alkyl branched c12ac24 fatty acids | |
| BR9901551B1 (en) | process for preparing 13-cis -retinoic acid. | |
| BR0016494A (en) | Bis (4-hydroxyaryl) alkanes | |
| DK93190A (en) | PROCEDURE FOR PREPARING AN IODAROMATIC COMPOUND |