ECSP951412A - SEPARATION OF AMLODIPINE ENANTIOMERS - Google Patents
SEPARATION OF AMLODIPINE ENANTIOMERSInfo
- Publication number
- ECSP951412A ECSP951412A ECSP951412A ECSP951412A EC SP951412 A ECSP951412 A EC SP951412A EC SP951412 A ECSP951412 A EC SP951412A EC SP951412 A ECSP951412 A EC SP951412A
- Authority
- EC
- Ecuador
- Prior art keywords
- amlodipine
- separation
- isomers
- dmso
- enantiomers
- Prior art date
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical class CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical class OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
El invento se refiere a un procedimiento para la separación de los isómeros r-(+) y s-(-) de la amodipina a partir de sus mezclas, que comprende la reacción de la mezcla e isómeros con acido l- o -tartarico en un disolvente orgánico que contiene dimetil sulfoxido (dmso) suficiente para la precipitación de respectivamente un solvato de dmso de una sal de l-tartrato de la r-(+)-amlodipina, o un solvato de dmso de una sal de d-tartrato de la s-(-)-amlodipina.The invention relates to a process for separating the r - (+) and s - (-) isomers of amodipine from their mixtures, which comprises the reaction of the mixture and isomers with l- or -tartaric acid in an organic solvent containing dimethyl sulfoxide (dmso) sufficient for the precipitation of respectively a dmso solvate of a l-tartrate salt of r - (+) - amlodipine, or a dmso solvate of a d-tartrate salt of s - (-) - amlodipine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP951412 ECSP951412A (en) | 1995-03-23 | 1995-03-23 | SEPARATION OF AMLODIPINE ENANTIOMERS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP951412 ECSP951412A (en) | 1995-03-23 | 1995-03-23 | SEPARATION OF AMLODIPINE ENANTIOMERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP951412A true ECSP951412A (en) | 1996-05-10 |
Family
ID=42042057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP951412 ECSP951412A (en) | 1995-03-23 | 1995-03-23 | SEPARATION OF AMLODIPINE ENANTIOMERS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP951412A (en) |
-
1995
- 1995-03-23 EC ECSP951412 patent/ECSP951412A/en unknown
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