ECSP951504A - BREASTFEEDING - Google Patents
BREASTFEEDINGInfo
- Publication number
- ECSP951504A ECSP951504A ECSP951504A ECSP951504A EC SP951504 A ECSP951504 A EC SP951504A EC SP951504 A ECSP951504 A EC SP951504A EC SP951504 A ECSP951504 A EC SP951504A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- cycloalkyl
- formula
- aryl
- optionally substituted
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento proporciona compuestos de la formula: **formula** y sus sales aceptables farmaceuticamente, en la que r es cicloalquilo de c3-c7, arilo o alquilo de c1-c6, estando dicho alquilo de c1-c6 opcionalmente sustituido por fluor, -cooh, coo (alquilo de c1-c4), cicloalquilo de c3-c7, adamantilo, arilo de het1, y estando dicho cicloalquilo de c3-c7 opcionalmente sustituido por 1 o 2 sustituyentes, cada uno seleccionado independientemente de alquilo de c1-c4, ciloalquilo de c3-c7, alcoxi de c1-c4, hidroxi, fluor, fluoroalquilo de (c1-c4 y fluoroalcoxi de (c1-c4), r1 es fenilo, naftilo, tienilo, benzotienilo o indolilo, cada uno sustituido opcionalmente por 1 o 2 sustituyentes, cada uno seleccionado independientemente de alquilo de c1-c4, alcoxi de c1-c4, halo y trifluorometilo; r2 es -co2h, -conr3r4, -conr5(cicloalquilo de c3-c7), -nr5-(alcanoilo de c2-c5), -nr3r4, -nr5conr5r6, (cicloalquilo de c3-c7-alquilo de c1-c4)2n-, nr5cocf3, -nr5so2cf3, -nr5(so2alquilo de c1-c4), -nr5so2nr5r6, -nr5(so2arilo), -n(arilo)(so2alquilo de c1-c4), -or5, -o(cicloalquilo de c3-c7), -so2nr5r6, het3 o un grupo de la formula. **formula** x es alquileno de c1-c4; x1 es un enlace directo o alquileno de c1-c6; x2 es un enlace directo co, so2 o nr5co; y m es 0, 1 o 2; junto con intermedios usados en la preparacion de tales derivados, composiciones que los contienen y el uso de tales derivados como antagonistas de taquicinina.The invention provides compounds of the formula: ** formula ** and its pharmaceutically acceptable salts, wherein r is c3-c7 cycloalkyl, aryl or C1-c6 alkyl, said C1-c6 alkyl being optionally substituted by fluorine, -cooh, coo (C1-c4 alkyl), c3-c7 cycloalkyl, adamantyl, het1 aryl, and said c3-c7 cycloalkyl being optionally substituted by 1 or 2 substituents, each independently selected from c1-c4 alkyl , c3-c7 cyloalkyl, c1-c4 alkoxy, hydroxy, fluoro, fluoroalkyl of (c1-c4 and fluoroalkoxy of (c1-c4), r1 is phenyl, naphthyl, thienyl, benzothienyl or indolyl, each optionally substituted by 1 or 2 substituents, each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo and trifluoromethyl; R2 is -co2h, -conr3r4, -conr5 (c3-c7 cycloalkyl), -nr5- (c2 alkanoyl -c5), -nr3r4, -nr5conr5r6, (c3-c7-cycloalkyl-c1-c4-alkyl) 2n-, nr5cocf3, -nr5so2cf3, -nr5 (so2-c4-alkyl), -nr5so2nr5r6, -nr5 (so2aryl), -n (aryl) (c2-c4 so2alkyl), -or5, -o (c3-c7cycloalkyl), -so2nr5r6, het3 or a group of the formula. ** formula ** x is C1-C4 alkylene; x1 is a direct bond or C1-c6 alkylene; x2 is a direct link co, so2 or nr5co; and m is 0, 1 or 2; together with intermediates used in the preparation of such derivatives, compositions containing them and the use of such derivatives as tachykinin antagonists.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP951504 ECSP951504A (en) | 1995-08-09 | 1995-08-09 | BREASTFEEDING |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP951504 ECSP951504A (en) | 1995-08-09 | 1995-08-09 | BREASTFEEDING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP951504A true ECSP951504A (en) | 1996-12-13 |
Family
ID=42042149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP951504 ECSP951504A (en) | 1995-08-09 | 1995-08-09 | BREASTFEEDING |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP951504A (en) |
-
1995
- 1995-08-09 EC ECSP951504 patent/ECSP951504A/en unknown
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