ECSP951607A - PROCEDURE FOR PREPARING 1- (2 '- DESOXI - 2', 2'- DIFLUORO - D - RIBOFURANOSIL) - 4 - AMINOPYRIMIDIN - 2 - ONA, CASE X - 8961 - Google Patents

PROCEDURE FOR PREPARING 1- (2 '- DESOXI - 2', 2'- DIFLUORO - D - RIBOFURANOSIL) - 4 - AMINOPYRIMIDIN - 2 - ONA, CASE X - 8961

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Publication number
ECSP951607A
ECSP951607A ECSP951607A ECSP951607A EC SP951607 A ECSP951607 A EC SP951607A EC SP951607 A ECSP951607 A EC SP951607A EC SP951607 A ECSP951607 A EC SP951607A
Authority
EC
Ecuador
Prior art keywords
aminopyrimidin
difluoro
preparing
ribofuranosil
desoxi
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Richard Alan Berglun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP951607 priority Critical patent/ECSP951607A/en
Publication of ECSP951607A publication Critical patent/ECSP951607A/en

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  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Esta invención proporciona un procedimiento para preparar clorhidrato de gemcitabina que comprende desbloquear ß-1-(2¿-desoxi-2¿, 2¿-difluoro-3¿, 5¿-di-o-benzoil-D-ribofuranosil)-4-aminopirimidin-2-ona con una cantidad catalítica de una alquilamina en presencia de metanol o etanol en un ambiente fundamentalmente exento de agua; tratar la solución resultante con ácido clorhídrico y un antidisolvente; y recuperar el clorhidrato de gemcitabina sólido resultante.This invention provides a process for preparing gemcitabine hydrochloride comprising unblocking β-1- (2¿-deoxy-2¿, 2¿-difluoro-3¿, 5¿-di-o-benzoyl-D-ribofuranosyl) -4- aminopyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.

ECSP951607 1995-12-11 1995-12-11 PROCEDURE FOR PREPARING 1- (2 '- DESOXI - 2', 2'- DIFLUORO - D - RIBOFURANOSIL) - 4 - AMINOPYRIMIDIN - 2 - ONA, CASE X - 8961 ECSP951607A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP951607 ECSP951607A (en) 1995-12-11 1995-12-11 PROCEDURE FOR PREPARING 1- (2 '- DESOXI - 2', 2'- DIFLUORO - D - RIBOFURANOSIL) - 4 - AMINOPYRIMIDIN - 2 - ONA, CASE X - 8961

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP951607 ECSP951607A (en) 1995-12-11 1995-12-11 PROCEDURE FOR PREPARING 1- (2 '- DESOXI - 2', 2'- DIFLUORO - D - RIBOFURANOSIL) - 4 - AMINOPYRIMIDIN - 2 - ONA, CASE X - 8961

Publications (1)

Publication Number Publication Date
ECSP951607A true ECSP951607A (en) 1997-06-11

Family

ID=42042249

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP951607 ECSP951607A (en) 1995-12-11 1995-12-11 PROCEDURE FOR PREPARING 1- (2 '- DESOXI - 2', 2'- DIFLUORO - D - RIBOFURANOSIL) - 4 - AMINOPYRIMIDIN - 2 - ONA, CASE X - 8961

Country Status (1)

Country Link
EC (1) ECSP951607A (en)

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