ECSP951610A - TACHYCININ ANTAGONISTS - Google Patents

TACHYCININ ANTAGONISTS

Info

Publication number
ECSP951610A
ECSP951610A ECSP951610A ECSP951610A EC SP951610 A ECSP951610 A EC SP951610A EC SP951610 A ECSP951610 A EC SP951610A EC SP951610 A ECSP951610 A EC SP951610A
Authority
EC
Ecuador
Prior art keywords
phenyl
sulfur
tachycinin
antagonists
indole
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Soo Young Ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP951610 priority Critical patent/ECSP951610A/en
Publication of ECSP951610A publication Critical patent/ECSP951610A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se proporciona compuestos de fórmula I (gráfico), en la que R1 es fenil mono o disustituido, n es cero ó 1, X1 es oxígeno, azufre o =NCN, X2 y X3 son cada uno independientemente oxígeno o azufre, R2 es hidrógeno o metilo, R3 es fenilo, fenilo sustituido con halo, 2-naftilo, IH-indol-3-ilo o 1-metil-indol -3-ilo, Z es N(CH3) -o -CH2-, R4 es fenilo, 3,65 bis (trifluorometil) fenilo o piridilo, y R5 es hidrógeno, fenilo, 3,5 -bis (trifluorometil)fenilo o piridilo, por lo que , cuando X3 es azufre, Z es -N (CH3) -, y una sakl de adición de ácido del mismo que tiene actividad antagonista para taquicinina, y son útiles como sustancias farmacéuticamente, por ejemplo, para el tratamiento del dolor.Compounds of formula I (graph) are provided, wherein R1 is mono or disubstituted phenyl, n is zero or 1, X1 is oxygen, sulfur or = NCN, X2 and X3 are each independently oxygen or sulfur, R2 is hydrogen or methyl, R3 is phenyl, halo-substituted phenyl, 2-naphthyl, IH-indole-3-yl or 1-methyl-indole -3-yl, Z is N (CH3) -o -CH2-, R4 is phenyl, 3 , 65 bis (trifluoromethyl) phenyl or pyridyl, and R5 is hydrogen, phenyl, 3,5-bis (trifluoromethyl) phenyl or pyridyl, whereby, when X3 is sulfur, Z is -N (CH3) -, and a sakl of acid addition thereof having antagonist activity for tachykinin, and are useful as substances pharmaceutically, for example for the treatment of pain.

ECSP951610 1995-12-12 1995-12-12 TACHYCININ ANTAGONISTS ECSP951610A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP951610 ECSP951610A (en) 1995-12-12 1995-12-12 TACHYCININ ANTAGONISTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP951610 ECSP951610A (en) 1995-12-12 1995-12-12 TACHYCININ ANTAGONISTS

Publications (1)

Publication Number Publication Date
ECSP951610A true ECSP951610A (en) 1997-06-27

Family

ID=42042252

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP951610 ECSP951610A (en) 1995-12-12 1995-12-12 TACHYCININ ANTAGONISTS

Country Status (1)

Country Link
EC (1) ECSP951610A (en)

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