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Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
El invento se refiere a nuevos derivados del ácido nonatetraenoico, de fórmula (gráfico), en donde el enlace punteados es opcional y R1 y R2 son como se ha definido en la especificación, se unen selectivamente a los receptores X del ácido retinoico (RXR) tienen actividad anti-acné y potencian la actividad de los retinoides que ya tienen actividad RAR alfa.The invention relates to novel derivatives of nonatetraenoic acid, of the formula (graph), where the dotted bond is optional and R1 and R2 are as defined in the specification, selectively bind to retinoic acid X receptors (RXR) they have anti-acne activity and enhance the activity of retinoids that already have RAR alpha activity.