ECSP961758A - POLYMYXINE CONJUGATES - Google Patents

POLYMYXINE CONJUGATES

Info

Publication number
ECSP961758A
ECSP961758A ECSP961758A ECSP961758A EC SP961758 A ECSP961758 A EC SP961758A EC SP961758 A ECSP961758 A EC SP961758A EC SP961758 A ECSP961758 A EC SP961758A
Authority
EC
Ecuador
Prior art keywords
conjugates
polymyxin
polymyxine
endotoxin
degrees
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Prasad Koteswara Kapa
Gleb Kardash
Andrew Kucerovy
Philip Lake
Paul Gerard Mattner
Russel C Petter
Mahavir Prashad
Original Assignee
Sharma Sushill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sharma Sushill filed Critical Sharma Sushill
Priority to ECSP961758 priority Critical patent/ECSP961758A/en
Publication of ECSP961758A publication Critical patent/ECSP961758A/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a conjugados de polimixina B/dextrano o sales de los mismos solubles de agua, que tienen una actividad antiendotoxinica o en contra de las endotoxinas, mayor que la de la polimixina B no conjugada. Estos conjugados se pueden preparar mediante la reacción de la polimixina B o una sal de la misma, con detrano, en un medio acuoso a un pH desde aproximadamente 9.3 hasta aproximadamente 10 y a una temperatura desde aproximadamente 30 grados centigrados hasta aproximadamente 35 grados centigrados.The present invention relates to water-soluble polymyxin B / dextran conjugates or salts thereof, which have an anti-endotoxin or anti-endotoxin activity, greater than that of unconjugated polymyxin B. These conjugates can be prepared by reacting polymyxin B or a salt thereof, with detrane, in an aqueous medium at a pH of from about 9.3 to about 10 and at a temperature from about 30 degrees C to about 35 degrees Celsius.

ECSP961758 1996-05-23 1996-05-23 POLYMYXINE CONJUGATES ECSP961758A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP961758 ECSP961758A (en) 1996-05-23 1996-05-23 POLYMYXINE CONJUGATES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP961758 ECSP961758A (en) 1996-05-23 1996-05-23 POLYMYXINE CONJUGATES

Publications (1)

Publication Number Publication Date
ECSP961758A true ECSP961758A (en) 1997-11-20

Family

ID=42042488

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP961758 ECSP961758A (en) 1996-05-23 1996-05-23 POLYMYXINE CONJUGATES

Country Status (1)

Country Link
EC (1) ECSP961758A (en)

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