ECSP961815A - Metanosulfonato de (1s,2s)-1 - (4-hidroxifenil)-2-(4-hidroxi-4 -fenilpiperidin- 1-il)-1- propanol trihidrato - Google Patents
Metanosulfonato de (1s,2s)-1 - (4-hidroxifenil)-2-(4-hidroxi-4 -fenilpiperidin- 1-il)-1- propanol trihidratoInfo
- Publication number
- ECSP961815A ECSP961815A ECSP961815A ECSP961815A EC SP961815 A ECSP961815 A EC SP961815A EC SP961815 A ECSP961815 A EC SP961815A EC SP961815 A ECSP961815 A EC SP961815A
- Authority
- EC
- Ecuador
- Prior art keywords
- trihydrate
- salt
- phenylpiperidin
- hydroxyphenyl
- propanol
- Prior art date
Links
- -1 4-HYDROXYPHENYL Chemical class 0.000 title abstract 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N 1-propanol Substances CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 title abstract 2
- 229940044613 1-propanol Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 abstract 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 206010065040 AIDS dementia complex Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical compound CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- LKGCPYOBWLSCTK-UHFFFAOYSA-N methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O LKGCPYOBWLSCTK-UHFFFAOYSA-N 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
- 150000004684 trihydrates Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere al nuevo y clinicamente ventajoso trihidrato de la sal metanosulfonato de (1s,2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-1-il)-1-propanol (denominado en lo sucesivo como "sal de mesilato trihidrato"). Esta sal de sal mesilato trihidrato, asi como la correswpondiente mesilato anhidra y la base libre del (1s,2s)-1-(4-hidroxifenil)-2-4 hidroxi-4-fenilpiperidin-1-il)-1-propanol (denominado en lo sucesivo como el "mesilato anhidro" y la "base libre") exhibe actividad como antagonistas de los receptores de NMDA (ácido N-metil-D aspártico) y son útiles en le tratamiento de la epilepsia, ansiedad, isquemia cerebral, espasmos musculares, demencia multinfirtica, lesión cerebral traumática dolor demencia relacionada con el SIDA, hipoglucemia, migraña, esclerosis amiotrófica lateral adición a las drogas y al alcohol, síntomas de abstinencia del alcohol y de las drogas, condiciones psicóticas, incontienecia urinaria y enfermedades degenerativas del SNC (sistema nervioso central), tales como aplopejía, enfermedad de Alzheimer, enfermedad de Parkinson y enfermedad de Huntington.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961815 ECSP961815A (es) | 1996-07-05 | 1996-07-05 | Metanosulfonato de (1s,2s)-1 - (4-hidroxifenil)-2-(4-hidroxi-4 -fenilpiperidin- 1-il)-1- propanol trihidrato |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961815 ECSP961815A (es) | 1996-07-05 | 1996-07-05 | Metanosulfonato de (1s,2s)-1 - (4-hidroxifenil)-2-(4-hidroxi-4 -fenilpiperidin- 1-il)-1- propanol trihidrato |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP961815A true ECSP961815A (es) | 1997-11-04 |
Family
ID=42042545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP961815 ECSP961815A (es) | 1996-07-05 | 1996-07-05 | Metanosulfonato de (1s,2s)-1 - (4-hidroxifenil)-2-(4-hidroxi-4 -fenilpiperidin- 1-il)-1- propanol trihidrato |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP961815A (es) |
-
1996
- 1996-07-05 EC ECSP961815 patent/ECSP961815A/es unknown
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