ECSP961822A -
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
- Google Patents
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
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La presente invención trata de un nuevo proceso para la preparación de una atorvastatina amorfa donde la forma 1 de atorvastatina cristalina se disuelve en un solvente no-hidroxílico y después de la remoción del solvente se logra la atorvastatina amorfa.The present invention relates to a new process for the preparation of an amorphous atorvastatin where crystalline atorvastatin form 1 is dissolved in a non-hydroxylic solvent and after removal of the solvent amorphous atorvastatin is achieved.
ECSP9618221996-07-151996-07-15
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
ECSP961822A
(en)
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] -2- (4-FLUOROPHENYL) - [2,8-DIHIDROXI-5- (1-METHYLETHYL) -3-FENYL- 4-PHENYLAMINE) CARBONYL] -1H-PIRROL-1-ACIDO HEPTANOICO.
Crystalline form iii of hemicalcium salts of [r-(r*, r*)]-2-(4-fluorophenyl)-beta,delta -dyhydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h -ppyrol-1-heptane acid (atorvastatin)
HYDROLYSIS OF [R(R*,R*)]-2-(4-FLUOROPHENYL)-beta,delta-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE
NEW PROCESS FOR THE PRODUCTION OF AN AMORPHOUS CALCICA ACID SALT [R- (R *, R *)] - 2- (4- FLUOROFENILO) -ß, 6- DIHIDROXI- 5 - (1- METHYLETHYLL) - 3 - PHENYL -4 - [(FENYLAMINE) CARBONYL] - 1H- PIRROL - 1 - HEPTANOIC ACID
CRYSTALLINE FORM III OF THE HEMI CALCIUM SALTS OF [R- (R *, R *)] - 2- (4-FLUORPHENYL) -BETA-DELTA-DIHYDROXY-5- (1-METHYLETHYL) -3-PHENYL-4 - [( PHENYLAMINO) CARBONYL] -1H-PYRROL-1-HEPTANIC ACID (ATORVASTATIN)
Hydrolysis of [R(R*,R*)]-2-(4-Fluorophenyl)-b,D-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbonyl]-1H-Pyrrole-1-Heptanoic acid esters with calcium hydroxide.
HYDROLYSIS OF [R(R*,R*)]-2-(4-FLUOROPHENYL)-β, δ-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE