Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filedfiledCritical
Priority to ECSP961823priorityCriticalpatent/ECSP961823A/en
Publication of ECSP961823ApublicationCriticalpatent/ECSP961823A/en
238000000371solid-state nuclear magnetic resonance spectroscopyMethods0.000abstract1
Landscapes
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
La presente invención consiste en nuevas formas cristalina de ácido [R-(R*,R*)-2-(4-ifuorofenil)-B, 8-dihidroxi -5-(1 metiletil)-3-FENIL-4[FENILAMINO) CARBONIL]-1H-PIRROL-1-HEPTANOICO SAL DE hemi CALCIO denominadas forma I y forma II (y forma IV caracterizadas por su difracción en polvo en rayos X y/o por su RMN de estdo sólido. Asi mismo se describen métodos para la preparación de las mismas y sus composiciones farmacéuticas, que sirven como agentes para tratar la hiperlipidemia e hipecolesterolemia, como se detalla en las especificaciones dibujos y reivindicaciones que acompaño en sobre cerrado.The present invention consists of new crystalline forms of [R- (R *, R *) - 2- (4-ifuorophenyl) -B, 8-dihydroxy -5- (1-methylethyl) -3-FENYL-4 [PHENYLAMINE) CARBONIL] -1H-PIRROL-1-HEPTANOICO SAL DE hemi CALCIO called form I and form II (and form IV characterized by their powder diffraction in X-rays and / or by their solid state NMR. Likewise, methods are described for the preparation thereof and their pharmaceutical compositions, which serve as agents to treat hyperlipidemia and hypecholesterolemia, as detailed in the accompanying drawings and claims specifications enclosed.
implant material consisting of porous calcium phosphate or collagen and porous calcium phosphate, implant material consisting of allograft or collagen and allograft, method of preparation thereof, use of porous calcium phosphate or collagen and porous calcium phosphate in the preparation of said implant material and use of allograft or collagen and allograft in the preparation of said implant material
DERIVATIVES OF BENZOILO-3-HETEROCICLIL-SUBSTITUTED, PROCEDURE FOR ITS PREPARATION, INTERMEDIATE COMPOUNDS OF APPLICATION IN SUCH PROCEDURE, COMPOSITIONS THAT INCLUDE SUCH DERIVATIVES AND SUBSEQUENT SUBSIDIZED PROCEDURE,
Pyrazolylcarboxanilides, their application and preparation process, composition comprising them, processes for combating unwanted microorganisms in plants and materials and preparing compositions, hydroxyalkylpyrazolylcarboxanilides and ketones
A SALT OF A COMPOUND DERIVED FROM CARBOXYLLIC NAFTIRIDINE ACID, ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE TO PREPARE IT AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT
DERIVATIVES OF PIRAZOL-4-IL-HETAROIL, PROCEDURE FOR ITS PREPARATION, HERBICIDAL COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE TO CONTROL THE GROWTH OF UNDESIATED PLANTS WITH THE APPLICATION OF SUCH COMPOUNDS
SUBSTITUTED ARILCETONES, PROCEDURES FOR THEIR PREPARATION, USEFUL BENZOIL KETONES IN SUCH PROCEDURE, USE OF THESE COMPOUNDS FOR THE FIGHT AGAINST INDESEABLE PLANTS, AND COMPOSITIONS
SODIUM SALT COMPOUND OF (ACID (E) 4,6-DICHLORO-3- (2-OXO-1- FENILPIRROLIDIN-3-ILIDENO-METHYL) -1H-INDOL-2-CARBOXILICO IN ITS HYDRATED FORM, PROCESS FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND METHOD OF TREATMENT USING SUCH COMPOUND