ECSP961843A - ORGANOMETALLIC ADDITION TO KETONES - Google Patents
ORGANOMETALLIC ADDITION TO KETONESInfo
- Publication number
- ECSP961843A ECSP961843A ECSP961843A ECSP961843A EC SP961843 A ECSP961843 A EC SP961843A EC SP961843 A ECSP961843 A EC SP961843A EC SP961843 A ECSP961843 A EC SP961843A
- Authority
- EC
- Ecuador
- Prior art keywords
- compound
- formula
- graph
- defined above
- het
- Prior art date
Links
- 150000002576 ketones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 239000002253 acid Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- -1 bormo Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invención proporciona un procedimiento para preparar un compuesto de la fórmula (gráfico), o una de sus sales de adición de ácidos o de bases, en la que R es fenilo opcionalmente sustituido por 1 a 3 sustituyentes, seleccionados cada uno independientemente entre halo y trifluorometilo; R1 es alquilo de C1-C6; y Het es pirimidilo opcionalmente sustituido por 1 a 3 sustituyentesm, seleccionados cada uno independientemente entre alquilo de C1-C4, alcoxi de C1-C4, halo, oxo, bencilo y benciloxi, que comprende la reacción de un compuesto de fórmula (gráfico), en la que R es como se ha definido anteriormente para un compuesto de fórmula (I), con un compuesto de fórmula (gráfico), en la que R es como se ha definido anteriormente para un compuesto de fórmula (I), con un compuesto de fórmula (gráfico), en la que R1 y Het son como se ha definido anteriormente para un compuesto de fórmula (I) y X es cloro, bormo, o yodo en presencia de conc, yodo y/o un pacido de lewis y un disolvente orgánico aprótico, estando seguido dicho procedimeinto opcionalmente por la conversión del compuesto de fórmula (I) en una sal de adición de ácidos o de bases del mismo.The invention provides a process for preparing a compound of the formula (graph), or one of its acid or base addition salts, wherein R is phenyl optionally substituted by 1 to 3 substituents, each independently selected from halo and trifluoromethyl; R1 is C1-C6 alkyl; and Het is pyrimidyl optionally substituted by 1 to 3 m substituents, each independently selected from C1-C4 alkyl, C1-C4 alkoxy, halo, oxo, benzyl, and benzyloxy, comprising the reaction of a compound of formula (graph), where R is as defined above for a compound of formula (I), with a compound of formula (graph), where R is as defined above for a compound of formula (I), with a compound of formula (graph), wherein R1 and Het are as defined above for a compound of formula (I) and X is chlorine, bormo, or iodine in the presence of conc, iodine, and / or a lewis and a aprotic organic solvent, said procedure being optionally followed by the conversion of the compound of formula (I) into an acid or base addition salt thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961843 ECSP961843A (en) | 1996-08-01 | 1996-08-01 | ORGANOMETALLIC ADDITION TO KETONES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961843 ECSP961843A (en) | 1996-08-01 | 1996-08-01 | ORGANOMETALLIC ADDITION TO KETONES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP961843A true ECSP961843A (en) | 1997-11-20 |
Family
ID=42042571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP961843 ECSP961843A (en) | 1996-08-01 | 1996-08-01 | ORGANOMETALLIC ADDITION TO KETONES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP961843A (en) |
-
1996
- 1996-08-01 EC ECSP961843 patent/ECSP961843A/en unknown
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