ECSP961906A - POLYMORPHIC FORMS OF A GROWTH HORMONE SEGREGATOR - Google Patents
POLYMORPHIC FORMS OF A GROWTH HORMONE SEGREGATORInfo
- Publication number
- ECSP961906A ECSP961906A ECSP961906A ECSP961906A EC SP961906 A ECSP961906 A EC SP961906A EC SP961906 A ECSP961906 A EC SP961906A EC SP961906 A ECSP961906 A EC SP961906A
- Authority
- EC
- Ecuador
- Prior art keywords
- growth hormone
- polymorphic forms
- methylpropanonide
- indola
- phenylmethyloxy
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 4
- 108010051696 Growth Hormone Proteins 0.000 title abstract 4
- 239000000122 growth hormone Substances 0.000 title abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- -1 phenylmethyloxy Chemical group 0.000 abstract 2
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical compound FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000014820 Galium aparine Nutrition 0.000 abstract 1
- 240000005702 Galium aparine Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000013622 meat product Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención tienen que ver con las formas polimórficas del compuesto N-[1®-[(1,2-dihidro-1-metanosulfonilespiro [3H-indola -3,4 -piperidina -1i-y1)carbonil]-2 - (fenilmetiloxi)etil]-2- amino -2- metilpropanonida -metanosulfonato el cual es un segregador de hormonas del crecimiento que es útil en animales comestibles para fomentar su crecimiento haciendo de este modo más eficeinte la producción de productos de carne comestible, y en humanos, el tratamiento de transtornos fisiológicos o médicos caracterizados por una deficiencia en la secreción de la hormona del crecimiento y para tratar transtorno médicos que son mejorados por los efectos anabólicos de la hormona del crecimiento. Las formas polimórficas instantáneas tienen vantajas con respecto a las otras formas conocidas de N-[1(r)-[(1,2 -dihidro-1- metanosulfonilespiro [3H-indola- 3,4i - piperidina -1i -y1)carbonil]-2- (fenilmetiloxi) etil] -2- amino -2- metilpropanonida -metanosulfonato en aminas de su estabilidad termodinámica y su idoneidad para su exclusión en formulaciones farmacéuticas. La presente invención tiene que ver con los procesos para la preparación de estas formas polimórficas, formulaciones farmacéuticas de la forma polimórfica del compuesto y sus formulaciones en el tratamiento de ciertos trastornos.This invention relates to the polymorphic forms of the compound N- [1® - [(1,2-dihydro-1-methanesulfonyl spiro [3H-indola -3,4 -piperidine -1i-y1) carbonyl] -2 - (phenylmethyloxy ) ethyl] -2- amino -2- methylpropanonide -methanesulfonate which is a growth hormone cleaver that is useful in edible animals to promote their growth thus making the production of edible meat products more efficient, and in humans, the treatment of physiological or medical disorders characterized by a deficiency in the secretion of growth hormone and to treat medical disorders that are ameliorated by the anabolic effects of growth hormone. The instantaneous polymorphic forms have advantages over the other known forms of N- [1 (r) - [(1,2-dihydro-1- methanesulfonyl-spiro [3H-indola- 3,4i-piperidine -1i -y1) carbonyl] -2- (phenylmethyloxy) ethyl] -2- amino -2- methylpropanonide -methanesulfonate in amines of its thermodynamic stability and its suitability for exclusion in pharmaceutical formulations. The present invention is concerned with processes for the preparation of these polymorphic forms, pharmaceutical formulations of the polymorphic form of the compound, and their formulations in the treatment of certain disorders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961906 ECSP961906A (en) | 1996-10-25 | 1996-10-25 | POLYMORPHIC FORMS OF A GROWTH HORMONE SEGREGATOR |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP961906 ECSP961906A (en) | 1996-10-25 | 1996-10-25 | POLYMORPHIC FORMS OF A GROWTH HORMONE SEGREGATOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP961906A true ECSP961906A (en) | 1997-12-23 |
Family
ID=42042632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP961906 ECSP961906A (en) | 1996-10-25 | 1996-10-25 | POLYMORPHIC FORMS OF A GROWTH HORMONE SEGREGATOR |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP961906A (en) |
-
1996
- 1996-10-25 EC ECSP961906 patent/ECSP961906A/en unknown
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