Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filedfiledCritical
Priority to ECSP961943priorityCriticalpatent/ECSP961943A/en
Publication of ECSP961943ApublicationCriticalpatent/ECSP961943A/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Peptides Or Proteins
(AREA)
Abstract
Se describen cicloheptapeptólidos de fórmula I A-B- R1LEU -LEU- C-X-Y en la que A, B, R1leu, leu, X X e Y son como se definen, y son inhibidores de la expresión de la expresión de moléculas de adhesión, e inhibidores de liberación de TNF y por lo tanto son útiles para el tratamiento de enfermedades inflamatorias y otras enfermedades las cuales involucran concentraciones elevadas de expresión de moléculas de adhesión y/o que son medidas por TNF.Cycloheptapeptolides of formula I are described AB-R1LEU -LEU-CXY where A, B, R1leu, leu, XX and Y are as defined, and are inhibitors of the expression of adhesion molecule expression, and release inhibitors of TNF and are therefore useful for the treatment of inflammatory diseases and other diseases which involve high concentrations of adhesion molecule expression and / or which are measured by TNF.