ECSP972029A - CHEMICAL PROCESS (PROCESS TO PREPARE NG MONOMETHYL-N-ARGININE CHLORHYDRATE) - Google Patents
CHEMICAL PROCESS (PROCESS TO PREPARE NG MONOMETHYL-N-ARGININE CHLORHYDRATE)Info
- Publication number
- ECSP972029A ECSP972029A ECSP972029A ECSP972029A EC SP972029 A ECSP972029 A EC SP972029A EC SP972029 A ECSP972029 A EC SP972029A EC SP972029 A ECSP972029 A EC SP972029A
- Authority
- EC
- Ecuador
- Prior art keywords
- monomethyl
- arginine
- chlorhydrate
- prepare
- chemical
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000004475 Arginine Substances 0.000 title 1
- 238000001311 chemical methods and process Methods 0.000 title 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NTNWOCRCBQPEKQ-YFKPBYRVSA-N N(omega)-methyl-L-arginine Chemical compound CN=C(N)NCCC[C@H](N)C(O)=O NTNWOCRCBQPEKQ-YFKPBYRVSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229960003589 arginine hydrochloride Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso para la preparación de clorhidrato de N(G)-monometil-L-arginina, el cual comprende la reacción de un compuesto de la fórmula (I) o una sal deadición de ácido del mismo, en donde L es un grupo saliente con L-ornitina o una sal de adición de ácido de la misma, en un solvente polar adecuado,seguida de acidificación hasta pH entre 4 y 5, y luego de la adición de un solvente alcohólico, se aisla el producto a partir de la mezcla de reacción,mediante cristalización.A process for the preparation of N (G) -monomethyl-L-arginine hydrochloride, which comprises the reaction of a compound of formula (I) or an acid addition salt thereof, where L is a leaving group with L-ornithine or an acid addition salt thereof, in a suitable polar solvent, followed by acidification to pH between 4 and 5, and after the addition of an alcoholic solvent, the product is isolated from the mixture of reaction, by crystallization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972029 ECSP972029A (en) | 1997-02-19 | 1997-02-19 | CHEMICAL PROCESS (PROCESS TO PREPARE NG MONOMETHYL-N-ARGININE CHLORHYDRATE) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972029 ECSP972029A (en) | 1997-02-19 | 1997-02-19 | CHEMICAL PROCESS (PROCESS TO PREPARE NG MONOMETHYL-N-ARGININE CHLORHYDRATE) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972029A true ECSP972029A (en) | 1998-01-22 |
Family
ID=42042862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972029 ECSP972029A (en) | 1997-02-19 | 1997-02-19 | CHEMICAL PROCESS (PROCESS TO PREPARE NG MONOMETHYL-N-ARGININE CHLORHYDRATE) |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972029A (en) |
-
1997
- 1997-02-19 EC ECSP972029 patent/ECSP972029A/en unknown
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