ECSP972048A - NEW HYDROXAMIC ACID DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE DEGRADATION OF THE CONNECTIVE TISSUE - Google Patents
NEW HYDROXAMIC ACID DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE DEGRADATION OF THE CONNECTIVE TISSUEInfo
- Publication number
- ECSP972048A ECSP972048A ECSP972048A ECSP972048A EC SP972048 A ECSP972048 A EC SP972048A EC SP972048 A ECSP972048 A EC SP972048A EC SP972048 A ECSP972048 A EC SP972048A
- Authority
- EC
- Ecuador
- Prior art keywords
- degradation
- treatment
- acid derivatives
- connective tissue
- hydroxamic acid
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 230000015556 catabolic process Effects 0.000 title abstract 2
- 210000002808 connective tissue Anatomy 0.000 title abstract 2
- 238000006731 degradation reaction Methods 0.000 title abstract 2
- 208000025865 Ulcer Diseases 0.000 abstract 3
- 230000036269 ulceration Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108060005980 Collagenase Proteins 0.000 abstract 1
- 102000029816 Collagenase Human genes 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108010026132 Gelatinases Proteins 0.000 abstract 1
- 102000013382 Gelatinases Human genes 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000025255 bacterial arthritis Diseases 0.000 abstract 1
- 229960002424 collagenase Drugs 0.000 abstract 1
- 210000004087 cornea Anatomy 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 230000009545 invasion Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108091007196 stromelysin Proteins 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención provee nuevos derivados del ácido hidroxámico representados por el compuesto de la fórmula I: (gráfico), o sus sales farmacéuticamente aceptables, en donde los compuestos de la presente invención inhiben varias enzimas de la familia metaloproteinasa de la matriz, incluyendo la colagenasa, estromelisina y gelatinasa, y en consecuencia son útiles para el tratamiento de enfermedades de metaloendoproteinasa de la matriz tales como osteoartritis, artritis reumatoidea, artritis bacteriana, osteopenias tales como osteoporosis, metástasis de tumores (invasión y desarrollo), periodontitis, gingivitis, ulceración de la córnea, ulceración dérmica, ulceración gastritica, y otras enfermedades relacionadas con la degradación del tejido conectivo.The present invention provides new hydroxamic acid derivatives represented by the compound of formula I: (graph), or its pharmaceutically acceptable salts, where the compounds of the present invention inhibit various enzymes of the matrix metalloproteinase family, including collagenase , stromelysin and gelatinase, and consequently are useful for the treatment of matrix metalloendoproteinase diseases such as osteoarthritis, rheumatoid arthritis, bacterial arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and development), periodontitis, gingivitis, ulceration of the cornea, dermal ulceration, gastritic ulceration, and other diseases related to the degradation of connective tissue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972048 ECSP972048A (en) | 1997-03-05 | 1997-03-05 | NEW HYDROXAMIC ACID DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE DEGRADATION OF THE CONNECTIVE TISSUE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972048 ECSP972048A (en) | 1997-03-05 | 1997-03-05 | NEW HYDROXAMIC ACID DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE DEGRADATION OF THE CONNECTIVE TISSUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972048A true ECSP972048A (en) | 1998-02-13 |
Family
ID=42042881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972048 ECSP972048A (en) | 1997-03-05 | 1997-03-05 | NEW HYDROXAMIC ACID DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RELATED TO THE DEGRADATION OF THE CONNECTIVE TISSUE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972048A (en) |
-
1997
- 1997-03-05 EC ECSP972048 patent/ECSP972048A/en unknown
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