ECSP972103A - INDOLIC DERIVATIVES USEFUL FOR THERAPY - Google Patents
INDOLIC DERIVATIVES USEFUL FOR THERAPYInfo
- Publication number
- ECSP972103A ECSP972103A ECSP972103A ECSP972103A EC SP972103 A ECSP972103 A EC SP972103A EC SP972103 A ECSP972103 A EC SP972103A EC SP972103 A ECSP972103 A EC SP972103A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- formula
- tetrazol
- alkenyl
- compounds
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 2
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere a derivados indólicos de la fórmula I, útiles en el tratamiento de diversas enfermedades incluyendo la reestenosis, (la insuficiencia renal, y la hipertensión pulmonar), y a formulaciones farmacéuticas que contienen dichos compuestos. Se trata de compuestos de fórmula l (como por ejemplo: Acido2- [3-(1-etil-6-metoxicrbonil)indolil]-2-(3,4-metilen-dioxifenil)acético) donde R1 y R2 son sustituyentes opcionales y representan independientemente alquilo, alquenilo, alquinilo, halógeno, perfluoroalquilo, etc;R3 representa H, alquilo, alquenilo, (CH2)pCN, (CH2)mHet, SO2NR7R8, etc;R4 representan H o alquilo;R5 se selecciona entre H o OH;y R6 significa entre fenilo opcionalmente condensado con un anillo heterocíclico saturado de 5 ó 6 elementos, que contiene 1 o 2 heteroátomos seleccionados entre N, S y O, estando el grupo en su totalidad opcionalmente sustituido con uno o más grupos;Z representa CO2H, CONH(tetrazol-5-ilo), CONHSO2O(alquilo), CO2Ar, CO2(alquilo),tetrazol-5-ilo, CONHSO2Ar, CONHSO2(alquilo). Una formulación farmacéutica que contiene un compuesto de fórmula l, o un derivado farmacéuticamente aceptable del mismo y un adyuvante, diluyente o vehículo farmacéuticamente aceptableThis invention relates to indole derivatives of formula I, useful in the treatment of various diseases including restenosis, (renal failure, and pulmonary hypertension), and to pharmaceutical formulations containing such compounds. These are compounds of formula 1 (such as: Acido2- [3- (1-ethyl-6-methoxycrbonyl) indolyl] -2- (3,4-methylene-dioxyphenyl) acetic acid) where R1 and R2 are optional substituents and independently represent alkyl, alkenyl, alkynyl, halogen, perfluoroalkyl, etc. R3 represents H, alkyl, alkenyl, (CH2) pCN, (CH2) mHet, SO2NR7R8, etc., R4 represents H or alkyl, R5 is selected from H or OH; and R6 stands for phenyl optionally fused with a 5- or 6-membered saturated heterocyclic ring, containing 1 or 2 heteroatoms selected from N, S, and O, the entire group being optionally substituted with one or more groups; Z represents CO2H, CONH (tetrazol-5-yl), CONHSO2O (alkyl), CO2Ar, CO2 (alkyl), tetrazol-5-yl, CONHSO2Ar, CONHSO2 (alkyl). A pharmaceutical formulation containing a compound of formula I, or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable adjuvant, diluent, or vehicle
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972103 ECSP972103A (en) | 1997-05-07 | 1997-05-07 | INDOLIC DERIVATIVES USEFUL FOR THERAPY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972103 ECSP972103A (en) | 1997-05-07 | 1997-05-07 | INDOLIC DERIVATIVES USEFUL FOR THERAPY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972103A true ECSP972103A (en) | 1998-04-17 |
Family
ID=42042934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972103 ECSP972103A (en) | 1997-05-07 | 1997-05-07 | INDOLIC DERIVATIVES USEFUL FOR THERAPY |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972103A (en) |
-
1997
- 1997-05-07 EC ECSP972103 patent/ECSP972103A/en unknown
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