ECSP972156A - METALOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AND USEFUL METHODS AND INTERMEDIATES FOR THEIR PREPARATION - Google Patents
METALOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AND USEFUL METHODS AND INTERMEDIATES FOR THEIR PREPARATIONInfo
- Publication number
- ECSP972156A ECSP972156A ECSP972156A ECSP972156A EC SP972156 A ECSP972156 A EC SP972156A EC SP972156 A ECSP972156 A EC SP972156A EC SP972156 A ECSP972156 A EC SP972156A
- Authority
- EC
- Ecuador
- Prior art keywords
- salts
- compounds
- preparation
- relates
- solvates
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000651 prodrug Substances 0.000 abstract 5
- 229940002612 prodrug Drugs 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000012453 solvate Substances 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la siguiente fórmula: (gráfico), donde Z es O ó S; V es un radical divalente que junto con C y N forman un anillo con seis tomos anulares aparte de C y N independientemente si no es sustituido o sustituido por un sustituyente apto, y por lo menos uno de dichos otros átomos anulares es un heteroátomo seleccionado de O, N, y S y el resto son átomos de carbono; y Ar es un grupo de arilo o heteroarilo; y profármacos, sales y solvatos farmacéuticamente aceptables de los mismos. La invención también trata además de profármacos, sales y solvatos farmacéuticamente aceptables de estos compuestos. La invención también trata de métodos de inhibir la actividad de las metaloproteinasas administrando un compuesto de fórmula I o un profármaco, una sal o un solvato del mismo. La invención además trata de composiciones farmacéuticas que comprenden una cantidad eficaz de estos compuestos, profármacos, sales y solvatos. La invención trata asi mismo métodos e intermedios útiles en la preparación de estos compuestos, profármacos sales y sovatos.The invention relates to compounds of the following formula: (graph), where Z is O or S; V is a divalent radical which together with C and N form a ring with six ring atoms apart from C and N independently if not substituted or substituted by a suitable substituent, and at least one of said other ring atoms is a hetero atom selected from O, N, and S and the rest are carbon atoms; and Ar is an aryl or heteroaryl group; and pharmaceutically acceptable prodrugs, salts and solvates thereof. The invention also relates in addition to pharmaceutically acceptable prodrugs, salts and solvates of these compounds. The invention also relates to methods of inhibiting metalloproteinase activity by administering a compound of formula I or a prodrug, a salt or a solvate thereof. The invention further relates to pharmaceutical compositions comprising an effective amount of these compounds, prodrugs, salts, and solvates. The invention also addresses methods and intermediates useful in the preparation of these compounds, prodrugs, salts and sovates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972156 ECSP972156A (en) | 1997-06-18 | 1997-06-18 | METALOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AND USEFUL METHODS AND INTERMEDIATES FOR THEIR PREPARATION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972156 ECSP972156A (en) | 1997-06-18 | 1997-06-18 | METALOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AND USEFUL METHODS AND INTERMEDIATES FOR THEIR PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972156A true ECSP972156A (en) | 1999-04-13 |
Family
ID=42042987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972156 ECSP972156A (en) | 1997-06-18 | 1997-06-18 | METALOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AND USEFUL METHODS AND INTERMEDIATES FOR THEIR PREPARATION |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972156A (en) |
-
1997
- 1997-06-18 EC ECSP972156 patent/ECSP972156A/en unknown
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