ECSP972201A - FUSION POLYPEPTIDES - Google Patents
FUSION POLYPEPTIDESInfo
- Publication number
- ECSP972201A ECSP972201A ECSP972201A ECSP972201A EC SP972201 A ECSP972201 A EC SP972201A EC SP972201 A ECSP972201 A EC SP972201A EC SP972201 A ECSP972201 A EC SP972201A
- Authority
- EC
- Ecuador
- Prior art keywords
- fusion polypeptides
- preparation
- intermediates
- fused
- polypeptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 230000004927 fusion Effects 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000024711 extrinsic asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Los polipéptidos de fusión y sales del mismo que comprenden al menos un dominio de unión de IgE fusionado al menos un componente de seroalbúmina humana, opcionalmente vía un enlazante peptídico, y en particular polipéptidos de fusión diméricos que comprenden proteína HSA fusionada, en cada uno de sus amino y carboxi terminales, a un dominio extracelular de la cadena alfa del receptor de alta afinidad humano para la IgE (FeERIalfa); los procesos para la preparación de los mismos, los polipéptidos funcionalmente equivalentes que son intermediarios en su preparación, y los intermedios polipéptidos y oligonucleotidicos y vectores de los mismos. Ellos están indicados para usarse en la prevención y/o tratamiento de enfermedades alérgicas medianas por la IgR y padecimientos relacionados tales como la dermatitis atópica, asma atópica y curticaria crónica.Fusion polypeptides and salts thereof comprising at least one IgE binding domain fused to at least one component of human serum albumin, optionally via a peptide linker, and in particular dimeric fusion polypeptides comprising fused HSA protein, in each of its amino and carboxy termini, to an extracellular domain of the human IgE high affinity receptor alpha chain (FeERIalfa); the processes for the preparation thereof, the functionally equivalent polypeptides that are intermediates in their preparation, and the polypeptide and oligonucleotide intermediates and vectors thereof. They are indicated for use in the prevention and / or treatment of medium allergic IgR diseases and related conditions such as atopic dermatitis, atopic asthma and chronic curticaria.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972201 ECSP972201A (en) | 1997-07-25 | 1997-07-25 | FUSION POLYPEPTIDES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972201 ECSP972201A (en) | 1997-07-25 | 1997-07-25 | FUSION POLYPEPTIDES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972201A true ECSP972201A (en) | 1999-01-19 |
Family
ID=42043032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972201 ECSP972201A (en) | 1997-07-25 | 1997-07-25 | FUSION POLYPEPTIDES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972201A (en) |
-
1997
- 1997-07-25 EC ECSP972201 patent/ECSP972201A/en unknown
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