ECSP972206A - SUBSTITUTED PYRROLES - Google Patents
SUBSTITUTED PYRROLESInfo
- Publication number
- ECSP972206A ECSP972206A ECSP972206A ECSP972206A EC SP972206 A ECSP972206 A EC SP972206A EC SP972206 A ECSP972206 A EC SP972206A EC SP972206 A ECSP972206 A EC SP972206A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- aryl
- hydrogen
- independently
- aralkyl
- Prior art date
Links
- 150000003233 pyrroles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- -1 monoalkylaminoalkyl Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de la fórmula (gráfico), en la que R1 y R1¿con independencia entre si son alquilo, arilo, alquenilo o alquinilo; R2 y R2¿con independencia entre si son hidrógeno, alquilo, aralquilo, alcoxialquilo, hidroxialqluilo, haloalquilo, aminoalquilo, monoalquilaminoalquilo, dialquilaminoalquilo, acilaminoalquilo, alquilslulfonilaminoalquilo, arilsulfonil-aminoalquilo, mercaptoalquilo, alquiltioalquilo, carboxialquilo, alcoxicarbonialquilo, amonocarbonilalquilo, alquiltio o alquilsulfinilo; R4, R5, R6, R7, R4¿, R5¿, R6¿, Y R7¿con independencia entre si son hidrógeno. CH2OCR8, CO2R9, CH2OR10, CHO, CH2NR11R12, CON((R13)2 halógeno ciano, arilo, aralquiloxi, alquilo, hidroxi, alcoxi, ariloxi, haloalquilo, nitro, amino aralquiloxi, acilamino, monoalquiamino, dialquilamino, tio, alquiltio, alquilsulfinilo, alquilsulfonilo, arilsulfinilo, azida, fosfato o fosfonato, con la condición de que por lo menos uno de R4, R5, R6, Y R7 y por lo menos uno de R4, R5, R6 y R7 sea distinto de hidrógeno; con la condición de que si R6 es motoxi, entonces R5 o R5¿no sea metoxi, R8 es alquilo o arilo; R9 es alquilo o arilo; R10 es hidrógeno, alquilo o arilo; R11 y R12 con independencia entre si son hidrógeno, alquilo, arilo, aralquilo o acilo; R12 es hidrógeno, alquilo, arilo o aralquilo; y uno de X es Y significa O y el otro significa O.S.(H,OH) o (H,H); así como los productos previos farmacéuticamente aceptables de los compuestos ácidos de la fórmula I con bases o de los compuestos básicos de la fórmula I con ácidos, son agentes antiproliferativos útiles para el tratamiento del cáncer.Compounds of the formula (graph), wherein R1 and R1 - independently of one another are alkyl, aryl, alkenyl or alkynyl; R2 and R2¿con are independently hydrogen, alkyl, aralkyl, alkoxyalkyl, hidroxialqluilo, haloalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acylaminoalkyl, alquilslulfonilaminoalquilo, arylsulfonyl aminoalkyl, mercaptoalkyl, alkylthioalkyl, carboxyalkyl, alcoxicarbonialquilo, amonocarbonilalquilo, alkylthio or alkylsulfinyl; R4, R5, R6, R7, R4¿, R5¿, R6¿, and R7¿ independently of each other are hydrogen. CH2OCR8, CO2R9, CH2OR10, CHO, CH2NR11R12, CON ((R13) 2 halo cyano, aryl, aralkyloxy, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino aralkyloxy, acylamino, monoalkylamino, dialkylamino, thio, alkylthio, alkyls, alkylsulfonyl, arylsulfinyl, azide, phosphate, or phosphonate, provided that at least one of R4, R5, R6, and R7 and at least one of R4, R5, R6, and R7 is other than hydrogen; that if R6 is motoxy, then R5 or R5 is not methoxy, R8 is alkyl or aryl; R9 is alkyl or aryl; R10 is hydrogen, alkyl or aryl; R11 and R12 independently of each other are hydrogen, alkyl, aryl, aralkyl or acyl; R12 is hydrogen, alkyl, aryl or aralkyl; and one of X is Y means O and the other means OS (H, OH) or (H, H); as well as the pharmaceutically acceptable pre-products of the acidic compounds of formula I with bases or basic compounds of formula I with acids are useful antiproliferative agents for the treatment of cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972206 ECSP972206A (en) | 1997-07-28 | 1997-07-28 | SUBSTITUTED PYRROLES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972206 ECSP972206A (en) | 1997-07-28 | 1997-07-28 | SUBSTITUTED PYRROLES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972206A true ECSP972206A (en) | 1998-09-22 |
Family
ID=42043036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972206 ECSP972206A (en) | 1997-07-28 | 1997-07-28 | SUBSTITUTED PYRROLES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972206A (en) |
-
1997
- 1997-07-28 EC ECSP972206 patent/ECSP972206A/en unknown
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