ECSP972216A - MUSCARINIC ANTAGONISTS - Google Patents

MUSCARINIC ANTAGONISTS

Info

Publication number
ECSP972216A
ECSP972216A ECSP972216A ECSP972216A EC SP972216 A ECSP972216 A EC SP972216A EC SP972216 A ECSP972216 A EC SP972216A EC SP972216 A ECSP972216 A EC SP972216A
Authority
EC
Ecuador
Prior art keywords
compounds
muscarinic antagonists
formula
antagonists
substituted
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Derek B Lowe
Joseph A Kozlowski
John W Clader
Michael J Green
Craig D Boyle
Samuel Chackalamannil
Stuart W Mccombie
Wei K Chang
Joel G Berger
Robert Mcquade
Allen Barnett
Margaret Sherlock
Wing Tom
Sundeep Dugar
Lian-Yong Chen
Yuguang Wang
Jayaram R Tagat
Susan F Vice
Wayne D Vaccaro
Margaret E Browne
Theodros Asberom
Original Assignee
Allen Barnett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen Barnett filed Critical Allen Barnett
Priority to ECSP972216 priority Critical patent/ECSP972216A/en
Publication of ECSP972216A publication Critical patent/ECSP972216A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos de piperazina di-N-sustituída o piperidina 1,4-di-sustituida de acuerdo con la fórmula I (incluyendo todos los isómeros sales, ésteres y solvatos). (gráfico), en donde R, R1, R2, R3, R4, R21, R27, R28, X, Y y Z son como se definen en la presente antagonistas mucarínicos útiles para el tratamiento de trastornos cognitivos como ser la enfermedad de Alzheimer. También se describe composiciones farmacéuticas y métodos de preparación, se describen además combinaciones de compuestos sinérgicas de la fórmula que figura anteriormente con inhibidores de acetilcolinesterasa.Compounds of di-N-substituted piperazine or 1,4-di-substituted piperidine according to formula I (including all salt, ester and solvate isomers). (graph), wherein R, R1, R2, R3, R4, R21, R27, R28, X, Y and Z are as defined herein useful mucarinic antagonists for the treatment of cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also described, furthermore combinations of synergistic compounds of the formula given above with acetylcholinesterase inhibitors are described.

ECSP972216 1997-08-06 1997-08-06 MUSCARINIC ANTAGONISTS ECSP972216A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972216 ECSP972216A (en) 1997-08-06 1997-08-06 MUSCARINIC ANTAGONISTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972216 ECSP972216A (en) 1997-08-06 1997-08-06 MUSCARINIC ANTAGONISTS

Publications (1)

Publication Number Publication Date
ECSP972216A true ECSP972216A (en) 1999-01-19

Family

ID=42043046

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972216 ECSP972216A (en) 1997-08-06 1997-08-06 MUSCARINIC ANTAGONISTS

Country Status (1)

Country Link
EC (1) ECSP972216A (en)

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