ECSP972244A - BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS - Google Patents
BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORSInfo
- Publication number
- ECSP972244A ECSP972244A ECSP972244A ECSP972244A EC SP972244 A ECSP972244 A EC SP972244A EC SP972244 A ECSP972244 A EC SP972244A EC SP972244 A ECSP972244 A EC SP972244A
- Authority
- EC
- Ecuador
- Prior art keywords
- disease
- inhibitors
- derivatives
- treatment
- gelatinase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000011159 matrix material Substances 0.000 title 1
- 208000010496 Heart Arrest Diseases 0.000 abstract 2
- DCMAPGFQLNDBGH-UHFFFAOYSA-N 1,1'-biphenyl;butanoic acid Chemical class CCCC(O)=O.C1=CC=CC=C1C1=CC=CC=C1 DCMAPGFQLNDBGH-UHFFFAOYSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 abstract 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 abstract 1
- 102000013382 Gelatinases Human genes 0.000 abstract 1
- 108010026132 Gelatinases Proteins 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 abstract 1
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 abstract 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 abstract 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 102000029797 Prion Human genes 0.000 abstract 1
- 108091000054 Prion Proteins 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 208000007474 aortic aneurysm Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000009545 invasion Effects 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001617 migratory effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 210000000278 spinal cord Anatomy 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describen los compuestos de ácido bifenil butírico y sus derivados así como también los métodos para su preparación y sus composiciones farmacéuticas, que son útiles como inhibidores de las metaloproteinasas de matriz, particularmente la gelatinasa A (gelatinasa 72Kd) y estromelisina-1 para el tratamiento de las esclerosis múltiple, ruptura de placa ateroescclerótica, aneurisma aórtico, paro cardiaco, restenosis, enfermedad periodontal, ulceración corneana, tratamiento de las quemaduras, úlceras decubitables, curación de heridas, cáncer, inflamación dolo, artritis y otros transtornos autoinmunes o inllamatorios dependientes de la invación del tejido por leucocitos u otras células migratorias activadas, tratornos neurodegenerativos crónicos incluyendo el paro cardiaco, trauma cerebral, daño en la médula espinal, enfermedad de Alzheimer, esclerosis lateral amiotrófica, angiopatia amiloide cerebral, SIDA, enfermedad de Parkinson, enfermedad de Huntington, enfermedades de Prion, miastenia gravis, y distrofia muscular de Duchenne.Biphenyl butyric acid compounds and their derivatives are described as well as methods for their preparation and their pharmaceutical compositions, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (gelatinase 72Kd) and stromelysin-1 for treatment. of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, cardiac arrest, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubitable ulcers, wound healing, cancer, painful inflammation, arthritis and other autoimmune or inflammatory disorders dependent on tissue invasion by leukocytes or other activated migratory cells, chronic neurodegenerative disorders including cardiac arrest, brain trauma, spinal cord damage, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease sick ades de Prion, myasthenia gravis, and Duchenne muscular dystrophy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972244 ECSP972244A (en) | 1997-09-03 | 1997-09-03 | BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972244 ECSP972244A (en) | 1997-09-03 | 1997-09-03 | BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972244A true ECSP972244A (en) | 1998-12-14 |
Family
ID=42043075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972244 ECSP972244A (en) | 1997-09-03 | 1997-09-03 | BUTHENYL BUTIRIC ACIDS AND THEIR DERIVATIVES AS MATRIX METAZOPROTEIN INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972244A (en) |
-
1997
- 1997-09-03 EC ECSP972244 patent/ECSP972244A/en unknown
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