ECSP972291A - DERIVATIVES OF CEPALOSPORIN PIRIDINIO (CASE RN 4410/256) - Google Patents

DERIVATIVES OF CEPALOSPORIN PIRIDINIO (CASE RN 4410/256)

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Publication number
ECSP972291A
ECSP972291A ECSP972291A ECSP972291A EC SP972291 A ECSP972291 A EC SP972291A EC SP972291 A ECSP972291 A EC SP972291A EC SP972291 A ECSP972291 A EC SP972291A
Authority
EC
Ecuador
Prior art keywords
lower alkyl
substituted
hydrogen
alkyl
heterocyclyl
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Peter Angehrn
Urs Weiss
Ingrid Heinze Krauss
Malcolm Page
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP972291 priority Critical patent/ECSP972291A/en
Publication of ECSP972291A publication Critical patent/ECSP972291A/en

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  • Cephalosporin Compounds (AREA)

Abstract

Derivados de Cefalosporin piridino de la fórmula general I (gráfico), en donde R1 es hidrógeno, alquilo inferior, cicloalquilo o acetilo; X es CH o N; n es 0,1 o 2; m es 0 o 1; R2 es hidrógeno, alquilo inferior, w-hidroxi alquilo, bencilo o alquilo inferior-heterociclilo, estando el bencilo y el grupo heterociclilo insustutuido o sustituido por a lo menos uno de los grupos amino, ciano, carboxilo, hidroxilo, alquilo inferior, alcoxilo inferior o-CONR2, siendo R hidrógeno o alquilo inferior; o R2 es -CH2CON-R4R5; en donde R4, R5 son, independientemente hidrógeno, w-hidroxi-alquilo, fenilo, naftilo o heterocíclico, estando el fenilo, naftilo o heterociclilo insustituído o sustituído por a lo menos uno de los grupos de hidroxilo, opcionalmenteprotegido, halógeno, alquilo inferior opcionalmente sustituído, alcoxilo inferior opcionalmente sustituido, w-hidroxialquilo y/o ciano; o los grupos R4 y R5 forman conjuntamente un grupo de la fórmula (gráfico), con la salvedad de que m es 1, cuando el anillo de piridinio A es un piridinio-4-ilo; así como sus ésteres fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de fórmula I y de sus ésteres y sales.Cephalosporin pyridine derivatives of the general formula I (graph), wherein R1 is hydrogen, lower alkyl, cycloalkyl or acetyl; X is CH or N; n is 0.1 or 2; m is 0 or 1; R2 is hydrogen, lower alkyl, w-hydroxy alkyl, benzyl, or lower alkyl-heterocyclyl, the benzyl and heterocyclyl group being unsubstituted or substituted by at least one of the amino, cyano, carboxyl, hydroxyl, lower alkyl, lower alkoxy groups. o-CONR2, where R is hydrogen or lower alkyl; or R2 is -CH2CON-R4R5; wherein R4, R5 are independently hydrogen, w-hydroxy-alkyl, phenyl, naphthyl, or heterocyclic, with phenyl, naphthyl, or heterocyclyl being unsubstituted or substituted by at least one of the hydroxyl groups, optionally protected, halogen, optionally lower alkyl. substituted, optionally substituted lower alkoxy, w-hydroxyalkyl and / or cyano; or the groups R4 and R5 together form a group of the formula (graph), except that m is 1, when the pyridinium ring A is a pyridinium-4-yl; as well as its easily hydrolyzable esters, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and their esters and salts.

ECSP972291 1997-10-21 1997-10-21 DERIVATIVES OF CEPALOSPORIN PIRIDINIO (CASE RN 4410/256) ECSP972291A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP972291 ECSP972291A (en) 1997-10-21 1997-10-21 DERIVATIVES OF CEPALOSPORIN PIRIDINIO (CASE RN 4410/256)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP972291 ECSP972291A (en) 1997-10-21 1997-10-21 DERIVATIVES OF CEPALOSPORIN PIRIDINIO (CASE RN 4410/256)

Publications (1)

Publication Number Publication Date
ECSP972291A true ECSP972291A (en) 1998-11-23

Family

ID=42043120

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP972291 ECSP972291A (en) 1997-10-21 1997-10-21 DERIVATIVES OF CEPALOSPORIN PIRIDINIO (CASE RN 4410/256)

Country Status (1)

Country Link
EC (1) ECSP972291A (en)

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