Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filedfiledCritical
Priority to ECSP972303priorityCriticalpatent/ECSP972303A/en
Publication of ECSP972303ApublicationCriticalpatent/ECSP972303A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Pyrrole Compounds
(AREA)
Abstract
Las N-(glicilo N- sustituído)-2-cianopirrolidinas, por ejemplo, los compuestos de la fórmula I (gráfico), en donde R tiene diferentes significados, son novedosas, Estas inhiben la actividad de DPP-IV (dipeptidilpeptidasa-IV). Por consiguientes, se indican para utilizarse como productos farmacéuticos en la inhibición de DPP IV, y en tratamiento de condiciones mediadas por DPP-IV, tales como diabetis mellitus no dependiente de insulina, artritis, obesidad, osteoporosis y otras condiciones de mala tolerancia a la glucosa.The N- (N-substituted glycyl) -2-cyanopyrrolidines, for example, the compounds of formula I (graph), where R has different meanings, are novel, They inhibit the activity of DPP-IV (dipeptidylpeptidase-IV) . Accordingly, they are indicated for use as pharmaceuticals in DPP IV inhibition, and in treatment of DPP-IV mediated conditions, such as non-insulin dependent diabetes mellitus, arthritis, obesity, osteoporosis, and other conditions of poor tolerance to glucose.
HETEROCYCLIC COMPOUNDS PROCESS FOR THEIR PREPARATION PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND ITS UTILIZATION IN THE TREATMENT OF RELATED DIABETES AND DISEASES
compound or a pharmaceutically acceptable salt, solvate, solvate of such a salt or a prodrug thereof, methods for treating or preventing hyperlipidemic conditions, atherosclerosis, alzheimer's disease, and cholesterol-associated tumors, pharmaceutical formulation, process for preparing a compound or a pharmaceutically acceptable salt, solvate, solvate of such a salt or a prodrug thereof, and in combination
Compound, process for preparing and use thereof, method for producing an inhibitory effect of ibat on a warm-blooded animal, and, pharmaceutical composition
compound, prodrug, pharmaceutical composition, composition and method for modulating calcium receptor, method for preventing or treating bone disease, and, use of the compound or a salt thereof or a prodrug thereof
Compound or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof, process for preparing it, pharmaceutical composition, use of the compound, methods for producing a cholesterol absorption inhibiting effect, and for treating hyperlipidemic conditions in a warm-blooded animal, such as man, who needs such treatment, combination, and use of this
compound or a pharmaceutically acceptable salt, solvate, solvate of such a salt or a prodrug thereof, methods for treating or preventing hyperlipidemic conditions, atherosclerosis, alzheimer's disease, and cholesterol-associated tumors, pharmaceutical formulation, combination, and process for preparing a compound or a pharmaceutically acceptable salt, solvate, solvate of such a salt or a prodrug thereof