ECSP972328A - DERIVATIVES OF 4-HYDROXY-PIPERIDINE - Google Patents
DERIVATIVES OF 4-HYDROXY-PIPERIDINEInfo
- Publication number
- ECSP972328A ECSP972328A ECSP972328A ECSP972328A EC SP972328 A ECSP972328 A EC SP972328A EC SP972328 A ECSP972328 A EC SP972328A EC SP972328 A ECSP972328 A EC SP972328A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydroxy
- double bond
- hydrogen
- independently
- lower alkyl
- Prior art date
Links
- HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical class OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 2 -imidazoyl Chemical group 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento se refiere a un compuesto de fórmula I (gráfico), en donde X significa -o-, NH-, -CH2-, -CH=, -CHOH-, -CO-, -S-, -SO-, ó -SO2-; R1-R4 son independientemente la una con respecto a la otra, hidrógeno, hidroxi, alquilo inferior-sufonilamino, 1 ó 2 -imidazoílo o acetamido; R5-R8 son independientemente la una con respecto a la otra, hidrógeno, hidroxi, alquilo inferior, halógeno, alcoxi inferior, trifluormetido o trifluormetiloxi; a y b pueden ser un enlace doble, con la condición de que, cuando "a" sea una enlace doble, "b" no puede ser un enlace doble; n es 0-2; m es 1-3; p es 0 ó 1 y a sales de ésta, aceptable desde el punto de vista farmacéutico. Los compuestos de la presente invención, son bloqueantes selectivos del subtipo receptor de NMDA (N-metil-D-aspartato), los cuales se pueden utilizar en procesos mediadores subordinados al desarrollo de la CNS, incluyendo la función del aprendisaje y formación de memoria.The invention relates to a compound of formula I (graph), where X means -o-, NH-, -CH2-, -CH =, -CHOH-, -CO-, -S-, -SO-, or -SO2-; R1-R4 are independently from each other, hydrogen, hydroxy, lower alkyl-sufonylamino, 1 or 2 -imidazoyl or acetamido; R5-R8 are independently from each other, hydrogen, hydroxy, lower alkyl, halogen, lower alkoxy, trifluoromethyl or trifluoromethyloxy; a and b can be a double bond, provided that when "a" is a double bond, "b" cannot be a double bond; n is 0-2; m is 1-3; p is 0 or 1 and to salts thereof, acceptable from the pharmaceutical point of view. The compounds of the present invention are selective blockers of the NMDA receptor subtype (N-methyl-D-aspartate), which can be used in mediating processes subordinated to the development of CNS, including the function of learning and memory formation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972328 ECSP972328A (en) | 1997-12-03 | 1997-12-03 | DERIVATIVES OF 4-HYDROXY-PIPERIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972328 ECSP972328A (en) | 1997-12-03 | 1997-12-03 | DERIVATIVES OF 4-HYDROXY-PIPERIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972328A true ECSP972328A (en) | 1998-12-14 |
Family
ID=42043157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972328 ECSP972328A (en) | 1997-12-03 | 1997-12-03 | DERIVATIVES OF 4-HYDROXY-PIPERIDINE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972328A (en) |
-
1997
- 1997-12-03 EC ECSP972328 patent/ECSP972328A/en unknown
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