ECSP972355A - NEW INHIBITORS OF FARNESIL TRANSFERS THEIR PREPARATION THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE PREPARATION OF MEDICINES - Google Patents
NEW INHIBITORS OF FARNESIL TRANSFERS THEIR PREPARATION THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE PREPARATION OF MEDICINESInfo
- Publication number
- ECSP972355A ECSP972355A ECSP972355A ECSP972355A EC SP972355 A ECSP972355 A EC SP972355A EC SP972355 A ECSP972355 A EC SP972355A EC SP972355 A ECSP972355 A EC SP972355A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- hydrogen
- preparation
- general formula
- optionally substituted
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229950008696 farnesil Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- -1 lakyloxy Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nuevos productos de fórmula general (I) su preparación, las composiciones farmacéuticas que les contienen y su utilización para la preparación de medicamentos (gráfico), en la fórmula general (I) Ar representa un radical fenilo sustituído o condensado, o un radical aromático policíclico o heterocíclico, R representa un radical de fórmula general -(CH2)m-I1-(CH2)n-Z, en la que X1 significa un enlace sencillo, O,S; m=0,1, n=0,1,2; los radicales CH2 pueden estar sustituídos; Z representa carboxi, COOR6, (R6=alquilo), CON (R7)(R8) (R7=hidrógeno o alquilo y R8=hidrógeno, hidroxi, arilsulfonilo, heterocíclico, amino eventualmente sustituído, alquiloxi eventualmente sustituído, alquilo eventualmente sustituído, amino, PO(OR9)2r) = hidrógeno o alquilo), un radical -NH-CO-T(T= hidrógeno o alquilo eventualmente sustituído, o bien un radical -CH2 (gráfico), R1 y R2= hidrógeno o halógeno o alquilo, alquiloxi eventualmente sustituído, alquiltio, alqluiloxicarbonilo o bien R1 y R2 en otro entresi, forman un teterocíclo que contiene 1 o 2 heteroátomos eventualmente sustituído, R3 y R4= hidrógeno o halógeno o alquilo, alquenilo, laquiloxi, alquiltio, carboxi o alquiloxicarbonilo, R5 es hidrógeno, alquilo, alquiltio; X= o So -NH-, -CO-, metileno, vinildiilo, alquen-1, 1-diilo o cicloalcan-1,1-diilo y Y= O o S en forma racémica asi como los isómeros ópticos y las sales del producto de fórmula general (I). Los productos de fórmula general (I) son inbihibidores de la farnesil transferasa que presentan propiedades antitumorales y antileucémicas considerables.New products of general formula (I) their preparation, the pharmaceutical compositions containing them and their use for the preparation of medicines (graph), in the general formula (I) Ar represents a substituted or condensed phenyl radical, or a polycyclic aromatic radical or heterocyclic, R represents a radical of the general formula - (CH2) m-I1- (CH2) nZ, where X1 signifies a single bond, O, S; m = 0.1, n = 0.1.2; CH2 radicals may be substituted; Z represents carboxy, COOR6, (R6 = alkyl), CON (R7) (R8) (R7 = hydrogen or alkyl and R8 = hydrogen, hydroxy, arylsulfonyl, heterocyclic, optionally substituted amino, optionally substituted alkyloxy, optionally substituted alkyl, amino, PO (OR9) 2r) = hydrogen or alkyl), a radical -NH-CO-T (T = hydrogen or optionally substituted alkyl, or a radical -CH2 (graphic), R1 and R2 = hydrogen or halogen or alkyl, alkyloxy optionally substituted, alkylthio, alkyluiloxycarbonyl or R1 and R2 in another entresi, form a teterocycle containing 1 or 2 possibly substituted heteroatoms, R3 and R4 = hydrogen or halogen or alkyl, alkenyl, lakyloxy, alkylthio, carboxy or alkyloxycarbonyl, R5 is hydrogen , alkyl, alkylthio; X = or So -NH-, -CO-, methylene, vinyldiyl, alken-1, 1-diyl or cycloalkan-1,1-diyl and Y = O or S in racemic form as well as the optical isomers and the salts of the product of general formula (I) .The products of general formula (I) are i Farnesyl transferase inhibitors that have considerable antitumor and antileukemic properties.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972355 ECSP972355A (en) | 1997-12-29 | 1997-12-29 | NEW INHIBITORS OF FARNESIL TRANSFERS THEIR PREPARATION THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE PREPARATION OF MEDICINES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972355 ECSP972355A (en) | 1997-12-29 | 1997-12-29 | NEW INHIBITORS OF FARNESIL TRANSFERS THEIR PREPARATION THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE PREPARATION OF MEDICINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972355A true ECSP972355A (en) | 1998-12-14 |
Family
ID=42043184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972355 ECSP972355A (en) | 1997-12-29 | 1997-12-29 | NEW INHIBITORS OF FARNESIL TRANSFERS THEIR PREPARATION THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE PREPARATION OF MEDICINES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972355A (en) |
-
1997
- 1997-12-29 EC ECSP972355 patent/ECSP972355A/en unknown
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