ECSP982372A - SULPHONAMIDES- N- LINKED HETERO CYCLIC THIOESTERS - Google Patents
SULPHONAMIDES- N- LINKED HETERO CYCLIC THIOESTERSInfo
- Publication number
- ECSP982372A ECSP982372A ECSP982372A ECSP982372A EC SP982372 A ECSP982372 A EC SP982372A EC SP982372 A ECSP982372 A EC SP982372A EC SP982372 A ECSP982372 A EC SP982372A
- Authority
- EC
- Ecuador
- Prior art keywords
- sulphonamides
- hetero cyclic
- cyclic thioesters
- linked hetero
- linked
- Prior art date
Links
- 150000007970 thio esters Chemical class 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 101710103508 FK506-binding protein Proteins 0.000 abstract 1
- 101710104425 FK506-binding protein 2 Proteins 0.000 abstract 1
- 101710104423 FK506-binding protein 3 Proteins 0.000 abstract 1
- 101710104333 FK506-binding protein 4 Proteins 0.000 abstract 1
- 101710104342 FK506-binding protein 5 Proteins 0.000 abstract 1
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 abstract 1
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 abstract 1
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 102100037827 Peptidyl-prolyl cis-trans isomerase D Human genes 0.000 abstract 1
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 abstract 1
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 abstract 1
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 abstract 1
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 abstract 1
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 abstract 1
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 abstract 1
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 abstract 1
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 abstract 1
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 abstract 1
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 abstract 1
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 abstract 1
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 abstract 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 abstract 1
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 abstract 1
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 abstract 1
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 abstract 1
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 abstract 1
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 abstract 1
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 abstract 1
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 abstract 1
- 108010020062 Peptidylprolyl Isomerase Proteins 0.000 abstract 1
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- -1 heterocyclic thioester Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002276 neurotropic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Esta invención está relacionada con las sulfonamidas neurotrópicas de tioésteres heterocíclicos con enlace N, de bajo peso molecular y de molécula pequeña, que tienen afinidad con las inmunifilinas tipo FKBP, y su uso como inhibidores de la actividad enzimática asociada con las proteínas de inmunifilina, particularmente la actividad enzimática de la peptidil-prolil isomerasa, o rotamasa.This invention relates to low molecular weight, small molecule, N-linked heterocyclic thioester neurotropic sulfonamides having affinity for FKBP-type immunifilins, and their use as inhibitors of enzyme activity associated with immunifilin proteins, particularly the enzymatic activity of peptidyl-prolyl isomerase, or rotamase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982372 ECSP982372A (en) | 1998-01-21 | 1998-01-21 | SULPHONAMIDES- N- LINKED HETERO CYCLIC THIOESTERS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982372 ECSP982372A (en) | 1998-01-21 | 1998-01-21 | SULPHONAMIDES- N- LINKED HETERO CYCLIC THIOESTERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982372A true ECSP982372A (en) | 1999-01-19 |
Family
ID=42043295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982372 ECSP982372A (en) | 1998-01-21 | 1998-01-21 | SULPHONAMIDES- N- LINKED HETERO CYCLIC THIOESTERS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982372A (en) |
-
1998
- 1998-01-21 EC ECSP982372 patent/ECSP982372A/en unknown
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