ECSP982407A - Phthazines - Google Patents
PhthazinesInfo
- Publication number
- ECSP982407A ECSP982407A ECSP982407A ECSP982407A EC SP982407 A ECSP982407 A EC SP982407A EC SP982407 A ECSP982407 A EC SP982407A EC SP982407 A ECSP982407 A EC SP982407A
- Authority
- EC
- Ecuador
- Prior art keywords
- oxa
- imino
- graph
- substituted
- alkyl
- Prior art date
Links
- -1 di-substituted amino Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la fórmula I (gráfico), en donde r es de 0 a 2, n es de 0 a 2; m es de 0 a 4; R1 y R2 (i) son en cada caso un alquilo inferior, o (ii) forman juntos un puente en la subfórmula I* (gráfico) ó (iii) forman juntos un puente en la subfórmula I** (gráfico), en donde uno o dos de os miembros del anillo T1,T2,T3 y T4 son nitrógeno, y el resto son en cada caso CH; A,B,D y E son N ó CH, en donde no más de dos de estos radicales son N: G es alquileno inferior, aciloxi- ó hidroxi-alquileno inferior, CH2-O-, -CH2-S-, CH2-NH-, oxa, tia, o imino; Q es metilo ; R es H o alquilo inferior; X es imino, oxa, o tia; Y es arilo, piridilo, o cicloalquilo(in) sustituido; y Z es amino mono- ó di-sustituído, halógeno, alquilo, alquilo sustituído, hidrexi, hidroxi esterificado o esterificado, nitro, ciano, carboxi, carboxi esterificado, alcanoilo, carbamoilo, carbamoilo N-mono- ó N,N-di-sustituído, amidino, guanidino, mercapto, sulfo, tiofenilo, feniltioalquilo inferior, alquiltiofenilo, fenilsulfinilo, fenilalquilo inferior-sulfinilo, alquilfenilsulfinilo, fenilsulfonilo, fenilalquilo inferior -sulfonilo o alquilfenilsulfonilo; y en donde los enlaces caracterizados por una línea ondulada son enlaces sencillos o dobles; o un N-óxido de dicho compuesto con la estipulación de que, si Y es piridilo o cicloalquilo insustituído, X es imino, y los radicales restantes son como se definieron, y entonces G se selecciona a partir del grupo que comprende alquileno inferior, -CH2O-, -CH2-S-, oxa y tía; o una sal de los mismos. Los compuestos inhiben la angiogénesis.The invention relates to compounds of formula I (graph), where r is from 0 to 2, n is from 0 to 2; m is 0 to 4; R1 and R2 (i) are in each case a lower alkyl, or (ii) together form a bridge in sub-formula I * (graph) or (iii) together form a bridge in sub-formula I ** (graph), where one or two of the ring members T1, T2, T3 and T4 are nitrogen, and the rest are in each case CH; A, B, D and E are N or CH, where no more than two of these radicals are N: G is lower alkylene, acyloxy- or hydroxy-lower alkylene, CH2-O-, -CH2-S-, CH2- NH-, oxa, tia, or imino; Q is methyl; R is H or lower alkyl; X is imino, oxa, or tia; Y is aryl, pyridyl, or (in) substituted cycloalkyl; and Z is mono- or di-substituted amino, halogen, alkyl, substituted alkyl, hydrexy, esterified or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, carbamoyl N-mono- or N, N-di- substituted amidino, guanidino, mercapto, sulfo, thiophenyl, phenylthio lower alkyl, alkylthiophenyl, phenylsulfinyl, phenylalkyl-sulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenylalkyl-sulfonyl or alkylphenylsulfonyl; and where the links characterized by a wavy line are single or double links; or an N-oxide of said compound with the stipulation that, if Y is pyridyl or unsubstituted cycloalkyl, X is imino, and the remaining radicals are as defined, and then G is selected from the group comprising lower alkylene, - CH2O-, -CH2-S-, oxa and aunt; or a salt thereof. The compounds inhibit angiogenesis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982407 ECSP982407A (en) | 1998-02-11 | 1998-02-11 | Phthazines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982407 ECSP982407A (en) | 1998-02-11 | 1998-02-11 | Phthazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982407A true ECSP982407A (en) | 1999-01-12 |
Family
ID=42043330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982407 ECSP982407A (en) | 1998-02-11 | 1998-02-11 | Phthazines |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982407A (en) |
-
1998
- 1998-02-11 EC ECSP982407 patent/ECSP982407A/en unknown
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