ECSP982468A - NICOTINAMIDE DERIVATIVES - Google Patents

NICOTINAMIDE DERIVATIVES

Info

Publication number
ECSP982468A
ECSP982468A ECSP982468A ECSP982468A EC SP982468 A ECSP982468 A EC SP982468A EC SP982468 A ECSP982468 A EC SP982468A EC SP982468 A ECSP982468 A EC SP982468A
Authority
EC
Ecuador
Prior art keywords
disease
respiratory
nicotinamide derivatives
allergic
inflammatory
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Anthony Marfat
Allen Jacob Duplantier
Robert James Chambers
John Wesley Watson
John Bin Cheng
Edward Fox Kleinman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP982468 priority Critical patent/ECSP982468A/en
Publication of ECSP982468A publication Critical patent/ECSP982468A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invención se refiere a derivados de nicotinamida que son inhibidores selectivos de la fosfodiesterasa de tipo 4 (PDE4) y de la producción del factor de necrosis tumoral (TNF) y que, como tales, son útiles en el tratamiento de trastornos respiratorios, alérgicos, reumatoides, de regulación del peso corporal, inflamatorios y del sistema nervioso central, tales como asma, enfermedad obstructiva crónica pulmonar, síndrome de enfermedades respiratorias en adultos, shock, fibrosis, hipersensibilidad pulmonar, rinitis alérgica, dermatitis atópica, psoriasis, control de peso, artritis reumatoide, caquexia, enfermedad de Crohn, colitis ulcerosa, afecciones artriticas y otras enfermedades inflamatorias, depresión, demencia multi-infarto y SIDA.This invention relates to nicotinamide derivatives that are selective inhibitors of type 4 phosphodiesterase (PDE4) and of tumor necrosis factor (TNF) production and which, as such, are useful in the treatment of respiratory, allergic, rheumatoids, body weight regulation, inflammatory and central nervous system, such as asthma, chronic obstructive pulmonary disease, respiratory disease syndrome in adults, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

ECSP982468 1998-04-02 1998-04-02 NICOTINAMIDE DERIVATIVES ECSP982468A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP982468 ECSP982468A (en) 1998-04-02 1998-04-02 NICOTINAMIDE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP982468 ECSP982468A (en) 1998-04-02 1998-04-02 NICOTINAMIDE DERIVATIVES

Publications (1)

Publication Number Publication Date
ECSP982468A true ECSP982468A (en) 1999-01-12

Family

ID=42043389

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP982468 ECSP982468A (en) 1998-04-02 1998-04-02 NICOTINAMIDE DERIVATIVES

Country Status (1)

Country Link
EC (1) ECSP982468A (en)

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