ECSP982495A - PROTEASE INHIBITORS IV - Google Patents
PROTEASE INHIBITORS IVInfo
- Publication number
- ECSP982495A ECSP982495A ECSP982495A ECSP982495A EC SP982495 A ECSP982495 A EC SP982495A EC SP982495 A ECSP982495 A EC SP982495A EC SP982495 A ECSP982495 A EC SP982495A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- alkenyl
- het
- protease inhibitors
- cycloalkyl
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Esta invención se refiere a compuestos de fórmula (I) (gráfico), en la que: R1 es R¿¿ , R¿¿C(O), R¿¿C(S), R¿¿SO2, R¿¿OC(O), R¿¿R1NC(O), o R¿¿OC(O)NR1CH(R6)C(O); R2 es H, alquilo C1-C6 alquenilo C2-C6, Ar-alquilo C0-C6 o Het-alquilo C0-C6; R3 es H, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, cicloalquil C3-C6 alquilo C0-C6, Ar-alquilo C0-C6, o Het-alquilo C0-C6; R4 es H, alquilo C1-C6, alquenilo C2-C6, Ar-alquilo C0-C6 o Het-alquilo C0-C6; R5 en cada caso, es independientemente H, alquilo C1-C6, alquenilo C2-C6, Ar-alquilo C0-C6; R6 es H, alquilo C1-C6, alquenilo C2-C6, cicloalquil C3-C6 alquilo C0-C6, Ar-alquilo C0-C6; o Het-alquilo C0-C6; R¿es H, alquilo C1-C6, alquenilo C2-C6 Ar-alquilo C0-C6 o Het-alquilo C0-C6; R¿¿ el alquilo C1-C6, Ar-alquilo C0-C6, Het-alquilo C0-C6, Ar-alquenilo C2-C6, o Het-alquenilo C2-C6; X es O o S; y n es 1,2 ó 3; o una de sus sales farmacéuticamente aceptables, que son inhibidores de cisteína proteasas, particularmente catepsina K, y son útiles en el tratamiento de enfermedades uno de cuyos factores es la inhibición de pérdida ósea.This invention relates to compounds of formula (I) (graph), in which: R1 is R¿¿, R¿¿ (O), R¿¿ (S), R¿¿SO2, R¿¿OC (O), R¿¿R1NC (O), or R¿¿OC (O) NR1CH (R6) C (O); R2 is H, C1-C6 alkyl, C2-C6 alkenyl, Ar-C0-C6 alkyl or Het-C0-C6 alkyl; R3 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C0-C6 alkyl, Ar-C0-C6 alkyl, or Het-C0-C6 alkyl; R4 is H, C1-C6 alkyl, C2-C6 alkenyl, Ar-C0-C6 alkyl or Het-C0-C6 alkyl; R5 in each case is independently H, C1-C6 alkyl, C2-C6 alkenyl, Ar-C0-C6 alkyl; R6 is H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, C0-C6 alkyl, Ar-C0-C6 alkyl; or Het-C0-C6-alkyl; R¿ is H, C1-C6 alkyl, C2-C6 alkenyl Ar-C0-C6 alkyl or Het-C0-C6 alkyl; R¿¿C1-C6-alkyl, Ar-C0-C6-alkyl, Het-C0-C6-alkyl, Ar-C2-C6-alkenyl, or Het-C2-C6-alkenyl; X is O or S; and n is 1,2 or 3; or one of its pharmaceutically acceptable salts, which are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases one of whose factors is the inhibition of bone loss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982495 ECSP982495A (en) | 1998-05-04 | 1998-05-04 | PROTEASE INHIBITORS IV |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982495 ECSP982495A (en) | 1998-05-04 | 1998-05-04 | PROTEASE INHIBITORS IV |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982495A true ECSP982495A (en) | 1999-01-26 |
Family
ID=42043416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982495 ECSP982495A (en) | 1998-05-04 | 1998-05-04 | PROTEASE INHIBITORS IV |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982495A (en) |
-
1998
- 1998-05-04 EC ECSP982495 patent/ECSP982495A/en unknown
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