ECSP982546A - QUATERNARY AMMONIUM COMPOUNDS - Google Patents
QUATERNARY AMMONIUM COMPOUNDSInfo
- Publication number
- ECSP982546A ECSP982546A ECSP982546A ECSP982546A EC SP982546 A ECSP982546 A EC SP982546A EC SP982546 A ECSP982546 A EC SP982546A EC SP982546 A ECSP982546 A EC SP982546A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- alkoxy
- fluoro
- cycloalkyl
- optionally substituted
- Prior art date
Links
- 150000003856 quaternary ammonium compounds Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- 125000001153 fluoro group Chemical group F* 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000001544 thienyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- -1 2,3-dihydrobenzo [b] furanyl Chemical group 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a un compuesto de fórmula: (gráfico), en la que R es fenilo, cicloalquilo C3-C7 o heteroarilo, estando cada uno de ellos opcionalmente condensado con un benceno o cicloalquilo C3-C7 y opcionalmente sustituido, incluyendo en la porción condensada con un benceno o cicloalquilo C3-C7, con 1 a 3 sustituyentes seleccionados cada uno de forma independiente entre alquilo C1-C4, fluoro(alquilo C1-C4), alcoxi C1-C4, fluoro (alcoxi C1-C4), fenoxi, alcanoilo C2-C4, halógeno, (alcoxi C1-C4)carbonilo, cicloalquilo C3-C7,-S(O)m (alquilo C1-C4), ciano, -NR2R3, -S(O) m NR2R3, -NR4(alcanoilo C1-C4) y -CONR2R3, o R ]es 2,3-dihidrobenzo [b] furanilo o cromanilo; R es H o alquilo C1-C6; W es un enlace directo, metileno o etileno; X es alquileno C2-C4 no ramificado; Y es fenilo, naftilo, bencilo, piridilo, tienilo o cicloalquilo C3-C7, estando cada uno de ellos opcionalmente sustituidos con 1 a 3 sustituyentes seleccionados, cada uno independientemente, entre alquilo C1-C4, fluoro (alquilo C1-C4), alcoxi C1-C4, fluoro (alcoxi C1-C4), halógeno y ciano; Ar es fenilo, naftilo, bencilo, tienilo, benzo [b] tienilo o indolilo, estando cada uno de ellos opcionalmente sustituidos con 1 a 3 sustituyentes seleccionados, cada uno independientemente, entre alquilo C1-C4, fluoro(alquilo C1-C4), alcoxi C1-C4, fluoro(alcoxi C1-C4), halógeno y ciano, o Ar es 1,3-benzodioxolan-4- ó -5-ilo o, 1,4-benzodioxan-5- ó -6-ilo; ZA es un anión farmacéuticamente aceptable; a condición de que cuando W es un enlace directo y R está opcionalmente condensado con un heteroarilo opcionalmente sustituido, dicho heteroarilo esta unido por un átomo de carbono del anillo al grupo carbonilo. Los compuestos son antagonistas de taquicininas.The present invention relates to a compound of the formula: (graph), wherein R is phenyl, C3-C7 cycloalkyl or heteroaryl, each being optionally fused with a benzene or C3-C7 cycloalkyl and optionally substituted, including in the condensed portion with a benzene or C3-C7 cycloalkyl, with 1 to 3 substituents each independently selected from C1-C4 alkyl, fluoro (C1-C4 alkyl), C1-C4 alkoxy, fluoro (C1-C4 alkoxy), phenoxy, C2-C4 alkanoyl, halogen, (C1-C4 alkoxy) carbonyl, C3-C7 cycloalkyl, -S (O) m (C1-C4 alkyl), cyano, -NR2R3, -S (O) m NR2R3, -NR4 (C1-C4 alkanoyl) and -CONR2R3, or R] is 2,3-dihydrobenzo [b] furanyl or chromanyl; R is H or C1-C6 alkyl; W is a direct bond, methylene or ethylene; X is unbranched C2-C4 alkylene; Y is phenyl, naphthyl, benzyl, pyridyl, thienyl, or C3-C7 cycloalkyl, each being optionally substituted with 1 to 3 selected substituents, each independently, from C1-C4 alkyl, fluoro (C1-C4 alkyl), alkoxy C1-C4, fluoro (C1-C4 alkoxy), halogen and cyano; Ar is phenyl, naphthyl, benzyl, thienyl, benzo [b] thienyl, or indolyl, each being optionally substituted with 1 to 3 selected substituents, each independently, from C1-C4 alkyl, fluoro (C1-C4 alkyl), C1-C4 alkoxy, fluoro (C1-C4 alkoxy), halogen, and cyano, or Ar is 1,3-benzodioxolan-4- or -5-yl or, 1,4-benzodioxan-5- or -6-yl; ZA is a pharmaceutically acceptable anion; provided that when W is a direct bond and R is optionally fused with an optionally substituted heteroaryl, said heteroaryl is attached by a ring carbon atom to the carbonyl group. The compounds are tachykinin antagonists.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982546 ECSP982546A (en) | 1998-06-18 | 1998-06-18 | QUATERNARY AMMONIUM COMPOUNDS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982546 ECSP982546A (en) | 1998-06-18 | 1998-06-18 | QUATERNARY AMMONIUM COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982546A true ECSP982546A (en) | 1999-01-26 |
Family
ID=42043466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982546 ECSP982546A (en) | 1998-06-18 | 1998-06-18 | QUATERNARY AMMONIUM COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982546A (en) |
-
1998
- 1998-06-18 EC ECSP982546 patent/ECSP982546A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200300428A1 (en) | ANTAGONISTS OF METABOTROPIC GLUTAMAT RECEPTORS | |
| UY25987A1 (en) | PROCEDURE FOR PREPARING RAS-FA RNESILTRANSFERASE AND SULFOBUTILETER-7-BETA-CYCLODEXTRIN OR 2- HYDROXYPROPIL-BETA-CYCLODEXTRIN AND METHOD COMPLEX | |
| AR021534A1 (en) | DERIVATIVES OF 1,4-DIAZABICICLO [3.2.2] NONANO, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS | |
| CO4780025A1 (en) | TRIARYL COMPOUNDS | |
| PE20000339A1 (en) | BICYCLE [2.2.1] HEPTANS AND RELATED COMPOUNDS | |
| ES2176311T3 (en) | NEW IMIDAZOL DERIVATIVES AND PROCEDURE FOR PREPARATION. | |
| AR037883A1 (en) | BENZOFURANS 2-PHENYL SUBSTITUTED AS STROGEN AGENTS | |
| ES2195933T3 (en) | NEW DERIVATIVES OF FLAVONAS, XANTONAS AND CUMARINAS. | |
| PL342178A1 (en) | Novel pyridinic compounds, method of obtaining them and pharmacological preparations containing such compounds | |
| MX9603202A (en) | Process for epoxidising prochiral olefins and a catalyst therefor and intermediates for making the catalyst. | |
| CO4900047A1 (en) | ACID AMIDES 4- (N -BENZOYLAMINE) -PENTEN-2-ENOIC WHICH HAVE ACTIVITY AS NEUROQUININE ANTAGONISTS | |
| EA200301317A1 (en) | DERIVATIVES OF AMINOHINOLINE AND ITS APPLICATION AS A3 LOSE Adenosine Ligands | |
| BG103919A (en) | Quaternary ammonium compounds as tachykinin antagonists | |
| BR0214373A (en) | 1,2,4-Triazole derivatives containing a sulfamate group as aromatase inhibitors | |
| ES2188029T3 (en) | PHENYL-RENT-IMIDAZOLS AS ANTAGONISTS OF THE H3 RECEIVER. | |
| ECSP982546A (en) | QUATERNARY AMMONIUM COMPOUNDS | |
| EA200200969A1 (en) | METHOD OF OBTAINING CYTALOPRAMA | |
| ES2144765T3 (en) | FLUORODERIVATIVES OF 4-AZAESTEROIDS SUBSTITUTED BY PHENYL. | |
| MX9700497A (en) | DERIVATIVE OF TRIFLUOROMETILQUINOLINOCARBOXILICO ACID. | |
| PT96422A (en) | PROCESS FOR THE PREPARATION OF UTILIZED PIPERIDINE AND PYRROLIDINE DERIVATIVES AS ANTICOLINERGIC AGENTS | |
| AR009293A1 (en) | QUATERNARY AMMONIUM COMPOSITE C3-C7 CYCLLOALKYL SUBSTITUTED, COMPOSITIONS CONTAINING THEM, USE OF THE SAME FOR THE MANUFACTURE OF MEDICINAL PRODUCTS, PROCEDURE FOR THE PREPARATION | |
| DE69906243T2 (en) | 2-indanemethanol derivatives and their use as fragrances | |
| ATE234837T1 (en) | 3-BICYCLOINDOLE AS LIGANDS OF THE 5-HT 1D RECEPTOR | |
| BG103986A (en) | Derivatives of pyrrolidinecarboxylic acids as endotheline antagonists | |
| AR016184A1 (en) | INDOLES 5-HETEROARIL SUBSTITUTED, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM, THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND FOR THE PREPARATION OF A RADIO-MARKING COMPOUND. |