ECSP982550A - DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA - Google Patents
DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREAInfo
- Publication number
- ECSP982550A ECSP982550A ECSP982550A ECSP982550A EC SP982550 A ECSP982550 A EC SP982550A EC SP982550 A ECSP982550 A EC SP982550A EC SP982550 A ECSP982550 A EC SP982550A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- phenyl
- proviso
- sulfonamido
- imidazoline
- Prior art date
Links
- -1 AMINOPHENYL Chemical class 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical group C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 2
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 2
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical group C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000032841 Bulimia Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010028735 Nasal congestion Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 201000011264 priapism Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical group C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a nuevos compuestos representados por la fórmula: (gráfico), en donde A R1q(R3R60N)m(Z) (NR2)n; m y q son cada uno 0 ó 1, con la condición de que cuando q es 1, m es 0 y cuando q es 0, m es 1; Z es C=0, m es 1; X es -NH-, -CH2- ó -OCH2-, Y es 2-imidazolina, 2-oxazolina, 2-tiazolina ó 4-imidazol; R1 es H, alquilo inferior o fenilo, con la condición de que cuando R1 es H, m es 1; R2, R3 y R60 son cado uno independientemente H, alquilo inferior, o fenilo; R4,R5,R6 y R7 son cada uno independientemente hidrógeno, alquilo inferior, -CF3-, alcoxilo inferior, halógeno, fenilo, alquenilo inferior, hidroxilo, (alquilo inferior)sulfonamido ó cicloalquilo inferior, en donde R2 y R7 opcionalmente pueden ser tomados juntos para formar un alquileno o alquenileno de 2 a 3 átomos de carbono en un anillo de 5 ó 6 miembros sin sustituir u opcionalmente sustituido, en donde los sustituyentes opcionales en el anillo son halo, alquilo inferior, ó -CN, con la condición de que cuando R7 es hedroxilo o (alquilo inferior)sulfonamido, entonces X no es -NH- cuando Y es 2-imidazolina. Los compuestos incluyen las sales farmacéuticamente aceptables de los anteriores. En la fórmula anterior A puede ser, por ejemplo (R1SO2NR2), (R3R60NSO2NR2), ó (R3R60NCONR2). La invención incluye también el empleo de los compuestos anteriores y composiciones que los contienen como alfa A/1L agonistas en el tratamiento de varios estados de enfermedad tales como la incontinencia urinaria, congestión nasal, priapismo, depresión, ansiedad, demencia, senilidad, deficiencias de la atención y razonamiento de la enfermedad de Alzheimer, y trastornos de la alimentación como la obesidad, bulimia y anorexia.The present invention relates to new compounds represented by the formula: (graph), where A R1q (R3R60N) m (Z) (NR2) n; m and q are each 0 or 1, with the proviso that when q is 1, m is 0 and when q is 0, m is 1; Z is C = 0, m is 1; X is -NH-, -CH2- or -OCH2-, Y is 2-imidazoline, 2-oxazoline, 2-thiazoline or 4-imidazole; R1 is H, lower alkyl or phenyl, with the proviso that when R1 is H, m is 1; R2, R3 and R60 are each independently H, lower alkyl, or phenyl; R4, R5, R6 and R7 are each independently hydrogen, lower alkyl, -CF3-, lower alkoxy, halogen, phenyl, lower alkenyl, hydroxyl, (lower alkyl) sulfonamido or cycloalkyl lower, wherein R2 and R7 can optionally be taken together to form a 2 to 3 carbon alkylene or alkenylene in an unsubstituted or optionally substituted 5- or 6-membered ring, wherein the optional substituents on the ring are halo, lower alkyl, or -CN, with the proviso that that when R7 is hedroxy or (lower alkyl) sulfonamido, then X is not -NH- when Y is 2-imidazoline. The compounds include the pharmaceutically acceptable salts of the above. In the above formula A can be, for example (R1SO2NR2), (R3R60NSO2NR2), or (R3R60NCONR2). The invention also includes the use of the above compounds and compositions containing them as alpha A / 1L agonists in the treatment of various disease states such as urinary incontinence, nasal congestion, priapism, depression, anxiety, dementia, senility, deficiencies of the attention and reasoning of Alzheimer's disease, and eating disorders such as obesity, bulimia and anorexia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982550 ECSP982550A (en) | 1998-06-22 | 1998-06-22 | DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982550 ECSP982550A (en) | 1998-06-22 | 1998-06-22 | DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982550A true ECSP982550A (en) | 1999-01-26 |
Family
ID=42043470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982550 ECSP982550A (en) | 1998-06-22 | 1998-06-22 | DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982550A (en) |
-
1998
- 1998-06-22 EC ECSP982550 patent/ECSP982550A/en unknown
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