ECSP982560A - 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED - Google Patents
4,5 DIARILIMIDAZOLES 2- SUBSTITUTEDInfo
- Publication number
- ECSP982560A ECSP982560A ECSP982560A ECSP982560A EC SP982560 A ECSP982560 A EC SP982560A EC SP982560 A ECSP982560 A EC SP982560A EC SP982560 A ECSP982560 A EC SP982560A
- Authority
- EC
- Ecuador
- Prior art keywords
- substituted
- substituent
- diseases
- thioryl
- aryltelide
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000018083 Bone metabolism disease Diseases 0.000 abstract 1
- 102000043136 MAP kinase family Human genes 0.000 abstract 1
- 108091054455 MAP kinase family Proteins 0.000 abstract 1
- HWGBHCRJGXAGEU-UHFFFAOYSA-N Methylthiouracil Chemical group CC1=CC(=O)NC(=S)N1 HWGBHCRJGXAGEU-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- -1 alkylcycloalkenium Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005410 aryl sulfonium group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona 4,5 -diarilimidazoles 2-sustituidos novedoso, en donde: i) el átomo de nitrógeno en la posición 1 está sustituido por un sustituyente que contiene trialquilsililo, o ii) el sustituyente en la posición es arilalquilo, arillsulfonio, tiorilo, arilseleno, arilteluro, cicloalquilo, cicloalquenilo, alquilcicloalquilo, alquilcicloalquenio, amino o hidrazino, o N-heterociclilo mono o bicíclico, en donde el anillo que contiene N tiene seis miembros del anillo en particular compuesto de la fórmula I (gráfico), en donde R1,R2,R3 y R4 son como se definieron, en forma libre o de sal de adición de ácido farmacéuticamente aceptable o de éster fisiológicamente disociable, que tienen actividad inhibidora de quinasa p38 MAP (quinasa de Proteína Activada por Mitógeno). Los compuestos se utilizan como productos farmacéuticos para el tratamiento de enfermedades mediadas por TNF alfa I1-1 tales como artritis reumatoide y enfermedades del metabolismo óseo, por ejemplo osteoporosis.Novel 2-substituted 4,5-diarylimidazoles are provided, wherein: i) the nitrogen atom at the 1-position is substituted by a trialkylsilyl-containing substituent, or ii) the substituent at the position is arylalkyl, arylsulfonium, thioryl, arylselene , aryltelide, cycloalkyl, cycloalkenyl, alkylcycloalkyl, alkylcycloalkenium, amino or hydrazino, or mono- or bicyclic N-heterocyclyl, wherein the N-containing ring has six ring members in particular compound of formula I (graph), wherein R1, R2, R3 and R4 are as defined, in free or pharmaceutically acceptable acid addition or physiologically dissociable ester addition form, having inhibitory activity of p38 MAP kinase (Mitogen Activated Protein kinase). The compounds are used as pharmaceuticals for the treatment of TNF alpha I1-1 mediated diseases such as rheumatoid arthritis and bone metabolism diseases, for example osteoporosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982560 ECSP982560A (en) | 1998-06-26 | 1998-06-26 | 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982560 ECSP982560A (en) | 1998-06-26 | 1998-06-26 | 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982560A true ECSP982560A (en) | 1999-02-11 |
Family
ID=42043480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982560 ECSP982560A (en) | 1998-06-26 | 1998-06-26 | 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982560A (en) |
-
1998
- 1998-06-26 EC ECSP982560 patent/ECSP982560A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR014886A1 (en) | 4,5-DIARILIMIDAZOLES 2-SUBSTITUTES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE FOR THE MANUFACTURE OF MEDICINES | |
| AR014903A1 (en) | COMPOUNDS OF TYPE 4-AMINO-PHENYLALANINE INHIBITORS OF THE ADHESION OF LEUCOCITS INTERMEDIATED BY VLA-4, COMPOUND THAT ARE DRUGS OF SUCH COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHOD TO ADHER VLA-4 IN A BIOLOGICAL METHOD | |
| PA8592001A1 (en) | HETEROAROMATIC GLOCOQUINASE ACTIVATORS OF SIX 5-SUBSTITUTED MEMBERS | |
| AR015419A1 (en) | COMPOUNDS DERIVED FROM HYDROXAMIC ARYLOXIALRILSULPHONYLAMINE ACIDS, COMPOSITIONS AND USE OF SUCH COMPOUNDS IN THE MANUFACTURE OF MEDICINES. | |
| AR026534A1 (en) | PIRROLO COMPOUNDS [2,3-D] PYRIMIDINE, PHARMACEUTICAL COMPOSITION CONTAINING THEM, ITS USE AS A MEDICINAL PRODUCT, ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND COMBINATION OF THE SAME WITH IMMUNE OR ANTIINFLAMATORY SYSTEM MODULATING AGENTS | |
| ES2092113T3 (en) | FLUOROALCOXYBENCILAMINE DERIVATIVES OF HETEROCICLES CONTAINING NITROGEN. | |
| ATE369370T1 (en) | SUBSTITUTED 2H-(1,2,4)TRIAZOLO(4,3-A)PYRAZINE AS GSK-3 INHIBITORS | |
| ES2221183T3 (en) | OXICARBAMILO COMPOUNDS THAT INHIBIT THE ADHESION OF LEUKOCYTES THROUGH VLA-4. | |
| MX9202943A (en) | TRICYCLE COMPOUNDS, PROCESS TO PREPARE THEM AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM. | |
| AR034858A1 (en) | ABCA-1 LIFTING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE MANUFACTURE OF A MEDICINAL PRODUCT | |
| ATE40994T1 (en) | L-N-N-PROPYLPIPECOLIC-2,6-XYLIDIDE AND ITS PRODUCTION. | |
| AR057873A2 (en) | COMPOUNDS DERIVED FROM PIPERIZINE USEFUL AS CCTA5 ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM, AND THE USE OF THEM FOR THE PREPARATION OF MEDICINES | |
| CO4810373A1 (en) | ARYL-CONDENSED AZAPOLYCLIC COMPOUNDS | |
| MX9300735A (en) | DERIVATIVES OF BENCIMIDAZOLYL, MEDICINES CONTAINING THESE COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION. | |
| CL2004000848A1 (en) | COMPOUNDS DERIVED FROM FENACIL-2-HIDROXI-3-DIAMINOALCANS, INHIBITORS OF THE ENZYME BETASECRETASA, USEFUL TO PREPARE A MEDICINAL PRODUCT TO TREAT ALZHEIMER, DOWN SYNDROME, HEREDITAR CEREBRAL HERIDAL AND OEREDOS | |
| DK0583421T3 (en) | Substituted dibenzoxazepine compounds, drugs and methods of use | |
| UY27244A1 (en) | USE OF ACID- (4´-TRIFLUORMETHYLPHENYL) - AMIDA (Z) -2- CYANO-3- HYDROXI-BUT-2-ENOIC FOR THE TREATMENT OF MULTIPLE SCLEROSIS | |
| PA8542601A1 (en) | LIPID REDUCING BIFENYL CARBOXAMIDS | |
| ES8707243A1 (en) | Thienopyridones, processes and intermediates for their preparation and pharmaceutical compositions containing them. | |
| EA200500882A1 (en) | N-ARILSULFONIL-3-AMINOALKOXIINDOLES | |
| MX9304424A (en) | BENZIMIDAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCEDURE FOR THEIR PREPARATION. | |
| UA27022C2 (en) | Carbasolon derivatives as intermediates for ondansetron synthesis | |
| ATE143025T1 (en) | ANTIVIRAL COMPOUNDS | |
| TR199900644T2 (en) | 1,2,3,4-Tetrahidro-benzofuro $ 3,2-c] piridin t.revleri. | |
| DE3573119D1 (en) | 8-alkylthio-2-piperazino-pyrimidoû5,4-d¨pyrimidines, their preparation and medicaments containing them |