ECSP982597A - DERIVATIVES OF 5H-TIAZOLO (3,2, a) PIRIMIDINE - Google Patents
DERIVATIVES OF 5H-TIAZOLO (3,2, a) PIRIMIDINEInfo
- Publication number
- ECSP982597A ECSP982597A ECSP982597A ECSP982597A EC SP982597 A ECSP982597 A EC SP982597A EC SP982597 A ECSP982597 A EC SP982597A EC SP982597 A ECSP982597 A EC SP982597A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- caused
- signify
- hydrogen
- cycloalkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- -1 -N (R13) 2 Chemical group 0.000 abstract 2
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 2
- 206010034010 Parkinsonism Diseases 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000020564 Eye injury Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 208000010496 Heart Arrest Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 206010057852 Nicotine dependence Diseases 0.000 abstract 1
- 208000026251 Opioid-Related disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 208000025569 Tobacco Use disease Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000003925 brain function Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 201000005040 opiate dependence Diseases 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento se refiere a compuestos de la fórmula general (gráfico), en donde R1 significa hidrógeno, alquilo inferior, fenilo o bencilo, R2 significa alquilo inferior, alcoxilo inferior, -O(CH2)Nn(R13) (R14), -(CH2)Nn(R13) (R14) o -N(R15)-(CH2)Nn(R13) (R14), R3-R12 significa hidrógeno, halógeno, trifluorometilo, alquilo inferior, cicloalquilo, alcoxilo inferior, hidroxilo, nitro, ciano, -N(R13)2, fenilo, feniloxilo, bencilo o benciloxilo, o R6 y R7 juntos significan un anillo de benceno, R13-R15 significan hidrógeno, alquilo inferior o cicloalquilo y n significa 1-5, así como sus sales farmacéuticamente aceptables. Estos compuestos son apropiados para el control o prevención de trastornos neurológicos agudos y/o crónicos, tal como función cerebral limitada causada por operaciones de bypass o transplantes, pobre riego sanguineo alcerebro, lesiones de médula espinal, lesión de la cabeza, hipoxia causada por gestación, paro cardiaco e hipoglicemia, enfermedad de Alzheimer, corea de Huntington ALS, demencia causada por SIDA, lesiones oculares, retinopatía, enfermedades cognitivas, parkinsonismo idiopático o parkinsonismo causado por medicamentos, asi como condiciones que conducen a funciones glutamato-deficientes, tal como, por ejemplo, espamos musculares, convulsiones, migraña, incontiencia urinaria, adicción a la nicotina, psicosis, adicción opiacea, ansiedad, vómitos, dolor crónico, diskinesia y depresiones.The invention relates to compounds of the general formula (graph), wherein R1 is hydrogen, lower alkyl, phenyl or benzyl, R2 is lower alkyl, lower alkoxy, -O (CH2) Nn (R13) (R14), - ( CH2) Nn (R13) (R14) or -N (R15) - (CH2) Nn (R13) (R14), R3-R12 means hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxyl, nitro, cyano , -N (R13) 2, phenyl, phenyloxy, benzyl or benzyloxy, or R6 and R7 together signify a benzene ring, R13-R15 signify hydrogen, lower alkyl or cycloalkyl and n signify 1-5, as well as their pharmaceutically acceptable salts. These compounds are appropriate for the control or prevention of acute and / or chronic neurological disorders, such as limited brain function caused by bypass or transplant operations, poor blood flow to the brain, spinal cord injury, head injury, hypoxia caused by pregnancy. , cardiac arrest and hypoglycemia, Alzheimer's disease, Huntington's chorea ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive diseases, idiopathic parkinsonism or parkinsonism caused by medications, as well as conditions that lead to glutamate-deficient functions, such as, for example, muscle spasms, seizures, migraine, urinary incontinence, nicotine addiction, psychosis, opiate addiction, anxiety, vomiting, chronic pain, diskinesia, and depression.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982597 ECSP982597A (en) | 1998-07-17 | 1998-07-17 | DERIVATIVES OF 5H-TIAZOLO (3,2, a) PIRIMIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982597 ECSP982597A (en) | 1998-07-17 | 1998-07-17 | DERIVATIVES OF 5H-TIAZOLO (3,2, a) PIRIMIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982597A true ECSP982597A (en) | 1999-12-23 |
Family
ID=42043517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982597 ECSP982597A (en) | 1998-07-17 | 1998-07-17 | DERIVATIVES OF 5H-TIAZOLO (3,2, a) PIRIMIDINE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982597A (en) |
-
1998
- 1998-07-17 EC ECSP982597 patent/ECSP982597A/en unknown
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