ECSP982601A - INDOL COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS - Google Patents
INDOL COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTSInfo
- Publication number
- ECSP982601A ECSP982601A ECSP982601A ECSP982601A EC SP982601 A ECSP982601 A EC SP982601A EC SP982601 A ECSP982601 A EC SP982601A EC SP982601 A ECSP982601 A EC SP982601A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrogen
- 4alkyl
- inflammatory
- analgesic agents
- 4alkoxy
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- -1 phenyl naphthyl Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Esta invención proporciona un compuesto de la siguiente fórmula: (gráfico), y las sales farmacéuticamente aceptables del mismo, en la que L es oxígeno o azufre; y es un enlace directo o alquilideno C1-4; Q es alquilo C1-6; cicloalquilo C3-7, fenilo naftilo, heteroarilo o similares; R1 es hidrógeno, alquilo C1-6 o similares; R2 es hidrógeno, alquilo C1-4, C(O)R5 donde R5 es alquilo C1-22 o alquenilo C2-22, alquilo C1-8 halosustituido, alquenilo C2-8 halosustituido -y- cicloalquilo C3-7 -y-cicloalquenilo C3-7 -y- cicloalquenilo C3-7, fenilo naftilo, heteroarilo o similares X es halo alquilo C1-4, hidroxi alcoxi C1-4 p similares; X es halo, alquilo C1-4, hidroxi, alcoxi C1-4 o similares; y n es o 1,2 ó 3 con la condición de que un grupo de fórmula -y-Q no es metilo o etilo cuando X es hidrógeno; L es oxigeno; R1 es hidrógeno; y R2 es acetilo. Esta invención también proporciona una composición farmacéutica útil para el tratamiento de una afección médica en la que estan implicadas lasprostaglandinas como patógenos.This invention provides a compound of the following formula: (graph), and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; y is a direct bond or C1-4alkylidene; Q is C1-6alkyl; C3-7cycloalkyl, phenyl naphthyl, heteroaryl or the like; R1 is hydrogen, C1-6 alkyl or the like; R2 is hydrogen, C1-4alkyl, C (O) R5 where R5 is C1-22alkyl or C2-22alkenyl, halosubstituted C1-8alkyl, C2-8alkenylhalosubstituted -y- C3-7cycloalkyl-C3 -7 -y- C3-7cycloalkenyl, phenyl naphthyl, heteroaryl, or the like X is halo C1-4alkyl, hydroxy C1-4alkoxy, or the like; X is halo, C1-4alkyl, hydroxy, C1-4alkoxy, or the like; and n is either 1,2 or 3 with the proviso that a group of the formula -y-Q is not methyl or ethyl when X is hydrogen; L is oxygen; R1 is hydrogen; and R2 is acetyl. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which lasprostaglandins are implicated as pathogens.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982601 ECSP982601A (en) | 1998-07-22 | 1998-07-22 | INDOL COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982601 ECSP982601A (en) | 1998-07-22 | 1998-07-22 | INDOL COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982601A true ECSP982601A (en) | 1999-02-11 |
Family
ID=42043521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982601 ECSP982601A (en) | 1998-07-22 | 1998-07-22 | INDOL COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982601A (en) |
-
1998
- 1998-07-22 EC ECSP982601 patent/ECSP982601A/en unknown
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