ECSP982656A - CERTAIN ENDOTHELINE ANTAGONISTS OF BENZOTIAZINE DIOXIDE AND PROCESSES FOR ITS PREPARATION - Google Patents
CERTAIN ENDOTHELINE ANTAGONISTS OF BENZOTIAZINE DIOXIDE AND PROCESSES FOR ITS PREPARATIONInfo
- Publication number
- ECSP982656A ECSP982656A ECSP982656A ECSP982656A EC SP982656 A ECSP982656 A EC SP982656A EC SP982656 A ECSP982656 A EC SP982656A EC SP982656 A ECSP982656 A EC SP982656A
- Authority
- EC
- Ecuador
- Prior art keywords
- benzotiazine
- dioxide
- processes
- preparation
- certain
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000002045 Endothelin Human genes 0.000 abstract 2
- 108050009340 Endothelin Proteins 0.000 abstract 2
- 206010008118 cerebral infarction Diseases 0.000 abstract 2
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 2
- GHNLJDPNIAIWOQ-UHFFFAOYSA-N 2h-1$l^{6},2-benzothiazine 1,1-dioxide Chemical class C1=CC=C2S(=O)(=O)NC=CC2=C1 GHNLJDPNIAIWOQ-UHFFFAOYSA-N 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 201000003099 Renovascular Hypertension Diseases 0.000 abstract 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención es una serie de dióxidos de benzotiazina o una sal farmacéuticamente aceptable de ellos, que son potentes antagonistas de endotelina A con profunda actividad en tubo de ensayo y sintesis mejoradas para la fórmula I (gráfico), los compuestos son útiles en el tratamiento de niveles elevados de endotelina, hipertensión esencial renovascular maligna y pulmonar, infarto cerebral, isquemia cerebral, insuficiencia cardiaca congestiva y hemorragia subaracnoide.The invention is a series of benzothiazine dioxides or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound test tube activity and improved syntheses for formula I (graph), the compounds are useful in the treatment of elevated endothelin levels, essential malignant and pulmonary renovascular hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982656 ECSP982656A (en) | 1998-09-04 | 1998-09-04 | CERTAIN ENDOTHELINE ANTAGONISTS OF BENZOTIAZINE DIOXIDE AND PROCESSES FOR ITS PREPARATION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982656 ECSP982656A (en) | 1998-09-04 | 1998-09-04 | CERTAIN ENDOTHELINE ANTAGONISTS OF BENZOTIAZINE DIOXIDE AND PROCESSES FOR ITS PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982656A true ECSP982656A (en) | 1999-04-16 |
Family
ID=42043576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982656 ECSP982656A (en) | 1998-09-04 | 1998-09-04 | CERTAIN ENDOTHELINE ANTAGONISTS OF BENZOTIAZINE DIOXIDE AND PROCESSES FOR ITS PREPARATION |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982656A (en) |
-
1998
- 1998-09-04 EC ECSP982656 patent/ECSP982656A/en unknown
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