ECSP982727A - IMIDAZOLE ILALQUILO SUBSTITUTED WITH A HETERO-CYCLE RING OF FIVE, SIX OR SEVEN MEMBERS CONTAINING A NITROGEN ATOM (CASE 0797K) - Google Patents
IMIDAZOLE ILALQUILO SUBSTITUTED WITH A HETERO-CYCLE RING OF FIVE, SIX OR SEVEN MEMBERS CONTAINING A NITROGEN ATOM (CASE 0797K)Info
- Publication number
- ECSP982727A ECSP982727A ECSP982727A ECSP982727A EC SP982727 A ECSP982727 A EC SP982727A EC SP982727 A ECSP982727 A EC SP982727A EC SP982727 A ECSP982727 A EC SP982727A
- Authority
- EC
- Ecuador
- Prior art keywords
- formula
- compound
- ilalquilo
- hetero
- imidazole
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 2
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 230000004410 intraocular pressure Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 206010011953 Decreased activity Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000009858 acid secretion Effects 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen compuestos que tienen la fórmula I (gráfico), o sales o solvatos de los mismos farmacéuticamente aceptables. También se describen composiciones farmacéuticamente que comprenden un portador farmacéuticamente aceptable y una cantidad eficaz de un compuesto de fórmula I. Además se describe un método para tratar alergias (por ejemplo asma), inflamación hipotensión, aumento de la presión intraocular (tal como glaucoma)- es decir un método para disminuir la presión intraocular, los desordenes del sueño, los estados de hiper e hipo motilidad, y la secreción ácida del tracto gastrointestinal, la hipo e hiper actividad del sistema nervioso central (por ejemplo agitación y depresión), y otros desórdenes del CNS (tal como enfermedad de Azheimer, esquizofrenia, obesidad y migraña) que comprende administrar una cantidad eficaz de un compuesto de fórmula I a un paciente que necesita dicho tratamiento. También se describen métodos para el tratamiento de las respuestas alérgicas de las vias respiratorias superiores que comprende administrar un compuesto o una sal o solvato del mismo de acuerdo con la fórmula I en combinación o en mezcla con un antagonista receptor de histamina K1Compounds having formula I (graph), or pharmaceutically acceptable salts or solvates thereof are described. Pharmaceutically compositions comprising a pharmaceutically acceptable carrier and an effective amount of a compound of formula I are also described. In addition, a method of treating allergies (eg, asthma), inflammation, hypotension, increased intraocular pressure (such as glaucoma) is described. that is, a method to decrease intraocular pressure, sleep disorders, hyper and hypomotility states, and acid secretion from the gastrointestinal tract, hypo and hyper activity of the central nervous system (for example agitation and depression), and others CNS disorders (such as Azheimer's disease, schizophrenia, obesity, and migraine) comprising administering an effective amount of a compound of formula I to a patient in need of such treatment. Methods for the treatment of allergic responses of the upper respiratory tract are also described which comprises administering a compound or a salt or solvate thereof according to formula I in combination or in admixture with a histamine K1 receptor antagonist.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982727 ECSP982727A (en) | 1998-11-05 | 1998-11-05 | IMIDAZOLE ILALQUILO SUBSTITUTED WITH A HETERO-CYCLE RING OF FIVE, SIX OR SEVEN MEMBERS CONTAINING A NITROGEN ATOM (CASE 0797K) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982727 ECSP982727A (en) | 1998-11-05 | 1998-11-05 | IMIDAZOLE ILALQUILO SUBSTITUTED WITH A HETERO-CYCLE RING OF FIVE, SIX OR SEVEN MEMBERS CONTAINING A NITROGEN ATOM (CASE 0797K) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982727A true ECSP982727A (en) | 1999-05-06 |
Family
ID=42043645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982727 ECSP982727A (en) | 1998-11-05 | 1998-11-05 | IMIDAZOLE ILALQUILO SUBSTITUTED WITH A HETERO-CYCLE RING OF FIVE, SIX OR SEVEN MEMBERS CONTAINING A NITROGEN ATOM (CASE 0797K) |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982727A (en) |
-
1998
- 1998-11-05 EC ECSP982727 patent/ECSP982727A/en unknown
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