ECSP982736A - PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. - Google Patents
PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P.Info
- Publication number
- ECSP982736A ECSP982736A ECSP982736A ECSP982736A EC SP982736 A ECSP982736 A EC SP982736A EC SP982736 A ECSP982736 A EC SP982736A EC SP982736 A ECSP982736 A EC SP982736A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- antagonists
- substance
- disorders
- ether compounds
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención proporciona un compuesto de fórmula: (gráfico), y sus sales farmacéuticamente aceptables en la que R1 es alquilo C1-C6, es hidrógeno, alquilo C1-C6, haloalquilo C1-C6 o fenilo; R3 es hidrógeno o halógeno R4 y R5 son independientemente hidrógeno, alquilo C1-C6 o haloalquilo C1-C6 y n es uno, dos o tres. Estos compuestos son útiles como análgesico o agentes anti-inflamatorios o para el tratamiento de enfermedades cardiovasculares, trastornos alérgicos, angiogénesis, trastornos del SNC, emesis, trastornos gastrointestinales, quemaduras solares, incontinencia urinaria o enfermedades trastornos y alteraciones adversas provocadas por helico-bacter pylori, o similar, en un mamifero especialmente un ser humano. También se describen intermedios para la preparación de los compuestos de fórmula (I).This invention provides a compound of formula: (graph), and its pharmaceutically acceptable salts wherein R1 is C1-C6 alkyl, is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl or phenyl; R3 is hydrogen or halogen R4 and R5 are independently hydrogen, C1-C6 alkyl or C1-C6 haloalkyl and n is one, two or three. These compounds are useful as analgesic or anti-inflammatory agents or for the treatment of cardiovascular diseases, allergic disorders, angiogenesis, CNS disorders, emesis, gastrointestinal disorders, sunburn, urinary incontinence or diseases and adverse disorders caused by helico-bacter pylori , or similar, in a mammal, especially a human being. Intermediates for the preparation of the compounds of formula (I) are also described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982736 ECSP982736A (en) | 1998-11-11 | 1998-11-11 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982736 ECSP982736A (en) | 1998-11-11 | 1998-11-11 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982736A true ECSP982736A (en) | 1999-04-16 |
Family
ID=42043654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982736 ECSP982736A (en) | 1998-11-11 | 1998-11-11 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982736A (en) |
-
1998
- 1998-11-11 EC ECSP982736 patent/ECSP982736A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4771153A1 (en) | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. | |
| DOP2001000271A (en) | IMIDAZOL COMPOUNDS CONDENSED WITH ARILO OR HETEROARILO AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS. | |
| CR10145A (en) | USEFUL TROPANAN DERIVATIVES IN THERAPY (DIVISIONAL EXP. 6800) | |
| AR006305A1 (en) | A REPLACED BENCILAMINOPIPERIDINE COMPOUND, ITS USE AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | |
| PE20030702A1 (en) | PDE9 INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS | |
| PE20030447A1 (en) | DERIVATIVES N- (1,4,5,6-TETRAHIDRO-CYCLOPENTAPYRAZOL-3-IL) -SUBTITUTED AND THEIR OBTAINING | |
| PE20020721A1 (en) | QUINUCLIDINE DERIVATIVES AS ANTIMUSCARINAL AGENTS M3 | |
| UY26872A1 (en) | DERIVATIVES OF THE 4- PIRIDINE PHENYL | |
| DK1065204T3 (en) | Bicyclic carbonyl indole compounds as anti-inflammatory / analgesic agents and as COX-2 inhibitors | |
| AR048289A1 (en) | ETERES OF RING IMIDAZO SULFONA REPLACED. | |
| HRP20090162T1 (en) | Quinolinone-carboxamide compounds as 5-ht4 receptor agonists | |
| PE10897A1 (en) | FUSED BENZO COMPOUNDS | |
| AR035502A1 (en) | A COMPOSITE DERIVED FROM PHENYL-REPLACED KETONE TYPE AS ANTAGONISTS OF THE PROSTAGLANDIN I2 RECEPTOR (IP), A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND, USE OF THE SAME AND A PROCESS TO PREPARE SUCH COMPOSITE | |
| AR029400A1 (en) | DERIVATIVES OF ISOXAZOLCARBOXAMIDA, A METHOD FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS | |
| PE20020905A1 (en) | DERIVATIVES OF ALCOXICARBONYLAMINOTETRAZOLIL PHENYL OR ALCOXYCARBONYLAMINE BENZOIC ACID AS IP ANTAGONISTS | |
| ECSP982736A (en) | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. | |
| AR023292A1 (en) | A COMPOUND DERIVED FROM IMIDAZOL, A PROCEDURE FOR ITS PREPARATION, AND A MEDICINAL AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND | |
| DOP2002000443A (en) | PROCESS FOR QUINAZOLIN PRODUCTION | |
| AR022797A1 (en) | BENZOIL INDOLES N-SUBSTITUTED AS ESTROGEN AGENTS | |
| UY26147A1 (en) | DERIVATIVES OF 1-TRIFLUOROMETIL-4-HIDROXI-7-PIPERIDINIL-AMINOMETILCROMANO. | |
| PE20001596A1 (en) | MORPHOLIN DERIVATIVES | |
| AR052949A1 (en) | METABOLITES DERIVED FROM PIRIDINE AS NK-1 ANTAGONISTS FOR EMESIS | |
| ES2152633T3 (en) | QUINUCLIDINES REPLACED WITH TETRAZOLIL AS ANTAGONISTS OF THE SUBSTANCE P. | |
| AR050718A1 (en) | CO-CRYSTALS BETWEEN POLYETHYLENE GLYCOLSY 5-PHENYLPIRAZOLIL-1-BENCENSULPHONAMIDS. PROCESSES OF OBTAINING AND PHARMACEUTICAL COMPOSITIONS. | |
| GT199800188A (en) | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLE ETHER COMPOUNDS AS ANTAGONISTS OF THE SUBSTANCE P. |