ECSP982763A - USEFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE - Google Patents
USEFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATEInfo
- Publication number
- ECSP982763A ECSP982763A ECSP982763A ECSP982763A EC SP982763 A ECSP982763 A EC SP982763A EC SP982763 A ECSP982763 A EC SP982763A EC SP982763 A ECSP982763 A EC SP982763A
- Authority
- EC
- Ecuador
- Prior art keywords
- conjugates
- prostate
- treatment
- cancer
- useful
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 2
- 201000001514 prostate carcinoma Diseases 0.000 title 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 2
- 108010038807 Oligopeptides Proteins 0.000 abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Se revelan conjugados químicos que comprenden oligopéptidos, que tienen secuencias de aminoácidos que son selectiva y proteoliticamente separadas por medio de un antígeno libre especifico de prostata (AEP) y agentes citotóxicos conocidos. Los conjugados de la invención se caracterizan por la unión de un oligopéptido separable a un átomo de oxígeno en la posición 4 de una droga vincapervinca que ha sido desacetilada. Dichos conjugados son útiles en el tratamiento de cáncer protático e hiperplasia prostática benigna.Chemical conjugates comprising oligopeptides are revealed, having amino acid sequences that are selectively and proteolytically separated by means of a prostate-specific free antigen (PSA) and known cytotoxic agents. The conjugates of the invention are characterized by the binding of a separable oligopeptide to an oxygen atom at position 4 of a vincapervinca drug that has been deacetylated. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hyperplasia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982763 ECSP982763A (en) | 1998-12-01 | 1998-12-01 | USEFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982763 ECSP982763A (en) | 1998-12-01 | 1998-12-01 | USEFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982763A true ECSP982763A (en) | 2000-08-18 |
Family
ID=42043682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982763 ECSP982763A (en) | 1998-12-01 | 1998-12-01 | USEFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982763A (en) |
-
1998
- 1998-12-01 EC ECSP982763 patent/ECSP982763A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9712589A (en) | Conjugate, pharmaceutical composition, processes to treat prostate cancer, to treat benign prostatic hyperplasia, and to make a pharmaceutical composition. | |
| CY1120577T1 (en) | USES OF SOLVENT CELLS CTLA4 SOLUTIONS | |
| NO20044039L (en) | Conjugators of therapeutic or cytotoxic agents and biologically active peptides. | |
| ATE378342T1 (en) | TERMINALLY BRANCHED POLYMERIC LINKERS AND POLYMERIC CONJUGATES CONTAINING SAME | |
| CY1109614T1 (en) | Molecular agents with factor VII or VIIA | |
| EP1009420A4 (en) | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | |
| DK1329458T5 (en) | Peptides that lower blood glucose levels | |
| CY1106366T1 (en) | LACTAM COMPOUND FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE OR SYNTHESIS | |
| HUP0300590A2 (en) | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use | |
| BR9815116A (en) | Conjugate, pharmaceutical composition, and, process to treat prostate cancer, and to treat benign prostatic hyperplasia | |
| DE60239707D1 (en) | ANTIMICROBIAL CATIONIC PEPTIDES AND FORMULATIONS CONTAINING THEM | |
| CY1116855T1 (en) | METHODS FOR PREPARATION OF CYTOTOTOXIC CONCENTRATES OF MITSINSINOIDS AND CELL BATTERY AGENTS | |
| DK1117440T3 (en) | Pharmaceutical compositions containing paclitaxel | |
| EP1017799A4 (en) | MUTED CLASS I-MHC MOLECULES | |
| CY1111095T1 (en) | AQUATIC COMPOUNDS CONTAINING METRONIDAZOL | |
| DE69940635D1 (en) | COPOLYMER COMPOSITIONS FOR ORAL ADMINISTRATION | |
| CY1120408T1 (en) | IMPROVED PHARMACEUTICAL FORMS | |
| CY1105237T1 (en) | IMPROVED PHARMACEUTICAL FORMULATIONS INCLUDING RITONAVIR | |
| DK1361895T3 (en) | End group branched polymeric linkers and polymeric conjugates containing these | |
| ECSP972297A (en) | HELPFUL CONJUGATES IN THE TREATMENT OF CANCER OF PROSTATE | |
| TR200102843T2 (en) | Combined composition for malaria treatment. | |
| YU34400A (en) | Conjugates useful in the treatment of prostate cancer | |
| EP1300159A4 (en) | REMEDIES AGAINST CANCER | |
| GT200100032A (en) | NEW FORM OF SALT AND POLYMORPHES | |
| GT199700003A (en) | QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY. |