ECSP992856A - DERIVATIVES OF PIRROLIDINE AND PIPERIDINE - Google Patents
DERIVATIVES OF PIRROLIDINE AND PIPERIDINEInfo
- Publication number
- ECSP992856A ECSP992856A ECSP992856A ECSP992856A EC SP992856 A ECSP992856 A EC SP992856A EC SP992856 A ECSP992856 A EC SP992856A EC SP992856 A ECSP992856 A EC SP992856A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrogen
- independently
- lower alkoxy
- conh2
- hydroxyl
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
El presente invento se refiere al empleo de derivados de pirrolidina y piperidina de las fórmulas generales (gráfico), en donde R1 y R2 son independientemente uno de otro, hidrógeno, alcoxilo inferior, hidroxilo, halógeno, -CONH2 o -(C(O)O-alquilo inferior; o tomados juntos son -O-CH2-O-; R3 y R4 son, independientemenmte uno de otro, hidrógeno, alcoxilo inferior, benciloxilo, halógeno, hidroxilo, -CONH2- o -SCH3; o tomados juntos son -O-CH2-O-; R5 es hidrógeno o alquilo inferior; X e Y son independientemente uno de otro -CH(OH)-, -(CH2)n-, -C(O) o -CH(alcoxilo inferior)-; y m, n y p son 1 o 2; y a sus sales de adición farmacéuticamente aceptables para el tratamiento de enfermedades causadass por sobreactivación de subtipos receptores de NMDA.The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formulas (graph), wherein R1 and R2 are independently of each other, hydrogen, lower alkoxy, hydroxyl, halogen, -CONH2 or - (C (O) O-lower alkyl; or taken together are -O-CH2-O-; R3 and R4 are, independently of each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxyl, -CONH2- or -SCH3; or taken together are - O-CH2-O-; R5 is hydrogen or lower alkyl; X and Y are independently from each other -CH (OH) -, - (CH2) n-, -C (O) or -CH (lower alkoxy) -; and m, n and p are 1 or 2, and their pharmaceutically acceptable addition salts for the treatment of diseases caused by over-activation of NMDA receptor subtypes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992856 ECSP992856A (en) | 1999-02-10 | 1999-02-10 | DERIVATIVES OF PIRROLIDINE AND PIPERIDINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992856 ECSP992856A (en) | 1999-02-10 | 1999-02-10 | DERIVATIVES OF PIRROLIDINE AND PIPERIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP992856A true ECSP992856A (en) | 2000-09-22 |
Family
ID=42043845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP992856 ECSP992856A (en) | 1999-02-10 | 1999-02-10 | DERIVATIVES OF PIRROLIDINE AND PIPERIDINE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP992856A (en) |
-
1999
- 1999-02-10 EC ECSP992856 patent/ECSP992856A/en unknown
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