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Application filed by Savoir John ClaudefiledCriticalSavoir John Claude
Priority to ECSP992861priorityCriticalpatent/ECSP992861A/en
Publication of ECSP992861ApublicationCriticalpatent/ECSP992861A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
La presente invención provee un almacenamiento estable, a paticulas formadas de compuestos orgánicos alotrópicos. La particulas de la presente invención pueden ser formadas de acuerdo con las aplicaciones deseadas. Las formas preferidas de tales partículas son las microesferas, particularmente aquellas que tienen un diámetro de alrededor de 1 a alrededor de 1,000 micrones. Las particulas formadas estables de la presente invención, son especialmente adecuadas para la fabricación de formulaciones farmacéuticas, en las cuales, la liberación prolongada y una biodisponibilidad uniforme son deseadas. Las particulas de almacenamiento estable son formadas, por cristalización al estado sólido de los compuestos orgánicos alotrópicos. El proceso de cristalización al estado sólido de la presente invención, proporciona un medio para lograr una forma cristalina, para almacenamiento estable de dicho compuesto alotrópico, sin pérdida o deterioro de las dimensiones originales de la partícula.The present invention provides stable storage for paticles formed from allotropic organic compounds. The particles of the present invention can be formed according to the desired applications. The preferred forms of such particles are microspheres, particularly those with a diameter of from about 1 to about 1,000 microns. The stable formed particles of the present invention are especially suitable for the manufacture of pharmaceutical formulations, in which prolonged release and uniform bioavailability are desired. Stable storage particles are formed, by solid state crystallization of allotropic organic compounds. The solid state crystallization process of the present invention provides a means to achieve a crystalline form, for stable storage of said allotropic compound, without loss or deterioration of the original dimensions of the particle.
ECSP9928611999-02-181999-02-18
PARTICLES OF STABLE FORM OF CRYSTAL ORGANIC COMPOUNDS
ECSP992861A
(en)
Process for carrying out a solid state crystallization of an allotropic molecular organic compound in a particle of defined size and shape, particle stable in storage, and process for carrying out a solid state crystallization of a mixture containing at least one allotropic organic organic compound.
NEW HETEROCICLIC COMPOUNDS THAT HAVE HYPOLIPIDEMIC, HYPOCOLESTEROLIC ACTIVITIES, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE IN MEDICINE
INHIBITING COMPOUNDS OF INTERACTION BETWEEN MDM2 AND P53, A METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND TO MANUFACTURE MEDICATIONS