ECSP992907A - CHROMANONE AND THIOCROMANONE DERIVATIVES - Google Patents

CHROMANONE AND THIOCROMANONE DERIVATIVES

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Publication number
ECSP992907A
ECSP992907A ECSP992907A ECSP992907A EC SP992907 A ECSP992907 A EC SP992907A EC SP992907 A ECSP992907 A EC SP992907A EC SP992907 A ECSP992907 A EC SP992907A
Authority
EC
Ecuador
Prior art keywords
alkyl
alkoxy
acyl
halogen
linked
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Andreas Billich
Ingeborg Schuster
Peter Nussbaumer
Erwin Schreiner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP992907 priority Critical patent/ECSP992907A/en
Publication of ECSP992907A publication Critical patent/ECSP992907A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a los compuestos de la fórmula: (gráfico), en donde: R1 y R2 son independientemente hidrógeno, acilo, alcoxicarbonilo, o alquilo: cualquier cadena lateral de sulfamoiloxi está enlazada con la posición 6, R3 es alquilo; alquenilo, alquinilo; una fracción de cicloalquilo opcionalmente sustituida por alquilo, alcoxi, o halógeno; arilalquilo; arilalquenilo; arilalquinilo; acilo; cicloalquialquilo; 3-oxo-2-oxacanfanilo; 6,6 -dimetil biciclico-(3.1.)hept -2-en -2-ilo; una fracción de heteroarilo opcionalmente sustituida por alquilo; alcoxi, o halógeno; o es heteroarilalquilo; y R4 es hidrógeno; alquilo; hidroxi; o alcoxi; o la cadena lateral de sulfamoiloxi está enlazada con la posición 7; R3 tiene el significado indicado anteriormente para R4; R4 tiene el significado indicado anteriormente para R3; X es O ó S; y el símbolo ------ es un enlace sencillo o doble en forma libre o en forma de sal. Estos se pueden preparar mediante la sulfamoilación de los compuestoshidroxilados correspondientes, mediante reducción y/o mediante N-sustitución. Estos se indican para utilizarse como productos farmacéuticos, particularmente en el tratamiento profiláctico o curativo de enfermedades que respondan a la inhibición de sulfatasa de esteroide.The invention relates to compounds of the formula: (graph), wherein: R1 and R2 are independently hydrogen, acyl, alkoxycarbonyl, or alkyl: any sulfamoyloxy side chain is linked at the 6-position, R3 is alkyl; alkenyl, alkynyl; a cycloalkyl fraction optionally substituted by alkyl, alkoxy, or halogen; arylalkyl; arylalkenyl; arylalkynyl; acyl; cycloalkyl alkyl; 3-oxo-2-oxacanfanil; 6,6-dimethyl bicyclic- (3.1.) Hept -2-en -2-yl; a heteroaryl fraction optionally substituted by alkyl; alkoxy, or halogen; o is heteroarylalkyl; and R4 is hydrogen; I rent; hydroxy; or alkoxy; or the sulphamoyloxy side chain is linked at position 7; R3 has the meaning indicated above for R4; R4 has the meaning indicated above for R3; X is O or S; and the symbol ------ is a single or double bond in free or salt form. These can be prepared by sulphamoylation of the corresponding hydroxy compounds, by reduction and / or by N-substitution. These are indicated for use as pharmaceuticals, particularly in the prophylactic or curative treatment of diseases that respond to inhibition of steroid sulfatase.

ECSP992907 1999-04-08 1999-04-08 CHROMANONE AND THIOCROMANONE DERIVATIVES ECSP992907A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP992907 ECSP992907A (en) 1999-04-08 1999-04-08 CHROMANONE AND THIOCROMANONE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP992907 ECSP992907A (en) 1999-04-08 1999-04-08 CHROMANONE AND THIOCROMANONE DERIVATIVES

Publications (1)

Publication Number Publication Date
ECSP992907A true ECSP992907A (en) 1999-06-11

Family

ID=42043896

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP992907 ECSP992907A (en) 1999-04-08 1999-04-08 CHROMANONE AND THIOCROMANONE DERIVATIVES

Country Status (1)

Country Link
EC (1) ECSP992907A (en)

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